ME/CFS Science @mecfsscience.org · 16/08/20265) We can also look at the individual genes that drive these associations with synapses. For DecodeME, these included synaptic genes such as: LRRC7 STAU1 ARFGEF2 CACNAIE DCC PEBP1 VWC2 NEURL1 INA SHISA6 DENND1A NRXN1 .... etc. 170
ME/CFS Science @mecfsscience.org · 16/08/20266) One of the clearest hits in DecodeME was for the gene CA10 on chromosome 17. It's involved in neurexin binding, so it has a clear connection to other genes on the list, such as NRXN1 (neurexin 1) and NLGN1 (Neuroligin 1). 190
ME/CFS Science @mecfsscience.org · 16/08/20267) This is clearly an area that warrants further study in ME/CFS. One idea is to use PET scans with new tracers ([11C]-UCB-J and [18F]SynVesT-1) that can measure synaptic density. It would be interesting to see whether, e.g., this is increased/reduced in various brain areas. 1110
