ME/CFS Science @mecfsscience.org · 16/08/20263) The results mostly point to the postsynaptic assembly and scaffolding at the membrane, so more about how synapses get built and wired rather than how they fire and release neurotransmitters. 391
ME/CFS Science @mecfsscience.org · 16/08/20264) For those curious about the methods: we used MAGMA to convert the DecodeME data into p-values associated with genes. This is done based on position, with a window size of 0: DNA letters that fall within genes contribute to the p-value of the gene. 180
ME/CFS Science @mecfsscience.org · 16/08/20265) We can also look at the individual genes that drive these associations with synapses. For DecodeME, these included synaptic genes such as: LRRC7 STAU1 ARFGEF2 CACNAIE DCC PEBP1 VWC2 NEURL1 INA SHISA6 DENND1A NRXN1 .... etc. 170
