ME/CFS Science @mecfsscience.org · 06/08/20262) All participants had to squeeze a grip device at 50% of their maximal force: 30 seconds of squeezing, 30 seconds of rest, repeated multiple times to generate fatigue. Fatigue was defined as no longer being able to generate the target force. 171
ME/CFS Science @mecfsscience.org · 06/08/20263) Fatigue occurred earlier in patients (around block 5) than in controls (at block 12). Patients were put inside an MRI to measure brain activity during the grip tasks. The researchers also measured electrical activity in the brain (EEG) and muscles (EEG). 170
ME/CFS Science @mecfsscience.org · 06/08/20264) The authors used the Dimitrov index as a measure of muscle fatigue. It reflects a shift from high frequencies toward low frequencies in the electrical signal. The controls had the expected increase in the Dimitrov index, while ME/CFS patients did not. 180
