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ME/CFS Science @mecfsscience.org · 06/08/2026

3) Fatigue occurred earlier in patients (around block 5) than in controls (at block 12). Patients were put inside an MRI to measure brain activity during the grip tasks. The researchers also measured electrical activity in the brain (EEG) and muscles (EEG).

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ME/CFS Science @mecfsscience.org · 06/08/2026

4) The authors used the Dimitrov index as a measure of muscle fatigue. It reflects a shift from high frequencies toward low frequencies in the electrical signal. The controls had the expected increase in the Dimitrov index, while ME/CFS patients did not.

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ME/CFS Science @mecfsscience.org · 06/08/2026

5) The brain results show a similar picture: the controls had an increase in EEG power and blood oxygenation during the task, while ME/CFS patients did not.

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