ME/CFS Science @mecfsscience.org · 06/08/20261) 🇺🇸 A new NIH study argues that the fatigue experienced by ME/CFS patients likely has a central (in the brain) rather than a peripheral (in muscle) origin. They put patients in an MRI scanner and recorded electromyography during grip strength exercises. A brief breakdown. 1288
ME/CFS Science @mecfsscience.org · 06/08/20262) All participants had to squeeze a grip device at 50% of their maximal force: 30 seconds of squeezing, 30 seconds of rest, repeated multiple times to generate fatigue. Fatigue was defined as no longer being able to generate the target force. 171
ME/CFS Science @mecfsscience.org · 06/08/20263) Fatigue occurred earlier in patients (around block 5) than in controls (at block 12). Patients were put inside an MRI to measure brain activity during the grip tasks. The researchers also measured electrical activity in the brain (EEG) and muscles (EEG). 170