ME/CFS Science @mecfsscience.org · 30/05/20266) The authors note that a small subset of LC patients had increased antibody levels against common autoantigens (similar to lupus patients) but most fell below the positivity threshold. The proportion of ANA-positives did not differ significantly per group. 180
ME/CFS Science @mecfsscience.org · 30/05/20267) The study took the HuProt proteins that bound to LC antibodies and looked at the biological pathways they are involved in. There was a lot of heterogeneity, but hormone signaling, cell adhesion, synaptic function, and neurogenesis came up. 180
ME/CFS Science @mecfsscience.org · 30/05/20268) One of the top hits was antibodies against the Mediator Complex Subunit 20 (MED20) which is involved in turning genes on and off. The paper lists findings suggesting these antibodies are pathologic such as reduced IgM/IgG ratio, complement deposition, etc. 171