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ME/CFS Science @mecfsscience.org · 30/05/2026

5) I had a look at antibodies against the β2/M3/M4 receptors that were previously found to be increased in ME/CFS (Loebel et al. 2016). Supplementary figure S6 shows that LC patients often had the highest levels, but the overall differences were not significant.

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ME/CFS Science @mecfsscience.org · 30/05/2026

6) The authors note that a small subset of LC patients had increased antibody levels against common autoantigens (similar to lupus patients) but most fell below the positivity threshold. The proportion of ANA-positives did not differ significantly per group.

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ME/CFS Science @mecfsscience.org · 30/05/2026

7) The study took the HuProt proteins that bound to LC antibodies and looked at the biological pathways they are involved in. There was a lot of heterogeneity, but hormone signaling, cell adhesion, synaptic function, and neurogenesis came up.

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