ME/CFS Science @mecfsscience.org · 30/05/20267) The study took the HuProt proteins that bound to LC antibodies and looked at the biological pathways they are involved in. There was a lot of heterogeneity, but hormone signaling, cell adhesion, synaptic function, and neurogenesis came up. 180
ME/CFS Science @mecfsscience.org · 30/05/20268) One of the top hits was antibodies against the Mediator Complex Subunit 20 (MED20) which is involved in turning genes on and off. The paper lists findings suggesting these antibodies are pathologic such as reduced IgM/IgG ratio, complement deposition, etc. 171
ME/CFS Science @mecfsscience.org · 30/05/20269) The authors included an independent cohort with 32 LC patients, but it looks like they used a different measurement for it: a microarray with 118 autoantigens. Here, LC patients had increased antibodies against several complement components. 160
