ME/CFS Science @mecfsscience.org · 30/05/20264) The CellTrend ELISA assay was used for more targeted testing. LC patients had higher levels of antibodies against GPCRs, such as adrenergic receptors, and against ionotropic receptors, such as NMDAR2C, a subunit of a glutamate receptor. 1110
ME/CFS Science @mecfsscience.org · 30/05/20265) I had a look at antibodies against the β2/M3/M4 receptors that were previously found to be increased in ME/CFS (Loebel et al. 2016). Supplementary figure S6 shows that LC patients often had the highest levels, but the overall differences were not significant. 2110
Ona Albizu - PhD MSc BD @onaalbizu.bsky.social · 30/05/2026You might want to have a look at this other paper www.nature.com/articles/s41...nature.comInvolvement of autoantibodies against G protein-coupled receptors in post-COVID condition and Chronic Fatigue Syndrome - Scientific ReportsScientific Reports - Involvement of autoantibodies against G protein-coupled receptors in post-COVID condition and Chronic Fatigue Syndrome 110
ME/CFS Science @mecfsscience.org · 30/05/20266) The authors note that a small subset of LC patients had increased antibody levels against common autoantigens (similar to lupus patients) but most fell below the positivity threshold. The proportion of ANA-positives did not differ significantly per group. 180
