ME/CFS Science @mecfsscience.org · 30/05/20263) Next, they searched for the targets of the antibodies using the HuProt™ microarray which includes over 21.000 different human proteins. Unfortunately, there wasn’t a clear difference in positive response to proteins between LC and convalescent controls (Figure 3B). 190
ME/CFS Science @mecfsscience.org · 30/05/20264) The CellTrend ELISA assay was used for more targeted testing. LC patients had higher levels of antibodies against GPCRs, such as adrenergic receptors, and against ionotropic receptors, such as NMDAR2C, a subunit of a glutamate receptor. 1110
ME/CFS Science @mecfsscience.org · 30/05/20265) I had a look at antibodies against the β2/M3/M4 receptors that were previously found to be increased in ME/CFS (Loebel et al. 2016). Supplementary figure S6 shows that LC patients often had the highest levels, but the overall differences were not significant. 2110