ME/CFS Science @mecfsscience.org · 30/05/20262) They extracted antibodies from blood and found that those from LC patients more often reacted to brain tissue such as the thalamus or locus coeruleus. However, after accounting for sex and age only the results for mouse meninges were significant. 1120
ME/CFS Science @mecfsscience.org · 30/05/20263) Next, they searched for the targets of the antibodies using the HuProt™ microarray which includes over 21.000 different human proteins. Unfortunately, there wasn’t a clear difference in positive response to proteins between LC and convalescent controls (Figure 3B). 190
ME/CFS Science @mecfsscience.org · 30/05/20264) The CellTrend ELISA assay was used for more targeted testing. LC patients had higher levels of antibodies against GPCRs, such as adrenergic receptors, and against ionotropic receptors, such as NMDAR2C, a subunit of a glutamate receptor. 1110
