ME/CFS Science @mecfsscience.org · 18/10/20255) The gene expression was regulated using heat-shock so the researchers could test different versions of ACOD1 overexpression by increasing the temperature of the water. The more the gene was expressed, the greater the signs of energy deficits. 160
ME/CFS Science @mecfsscience.org · 18/10/20256) It's unclear, however, if this model fits ME/CFS. At high expression of ACOD1, the fish also showed a reduced heart rate and signs of cardiac impairment. 260
ME/CFS Science @mecfsscience.org · 18/10/20257) Lastly, they tested multiple ACOD1 inhibitors and found that some restored movement in the zebrafish back to a normal amount. So if the Itaconate shunt model is correct, this could be a potential treatment. 170
Jackson Riso @jacksonriso.bsky.social · 18/10/2025What would make you more confident that the model does fit? What experiment or study would you need to see? 110
