ME/CFS Science @mecfsscience.org · 18/10/20254) In tests with lights or vibration as stimuli being turned on and off, the zebrafish with ACOD1 overexpression had approximately a 40% reduction in movement compared to controls. They also had reduced oxygen consumption. 160
ME/CFS Science @mecfsscience.org · 18/10/20255) The gene expression was regulated using heat-shock so the researchers could test different versions of ACOD1 overexpression by increasing the temperature of the water. The more the gene was expressed, the greater the signs of energy deficits. 160
ME/CFS Science @mecfsscience.org · 18/10/20256) It's unclear, however, if this model fits ME/CFS. At high expression of ACOD1, the fish also showed a reduced heart rate and signs of cardiac impairment. 260
