Prof. Shane Crotty @profshanecrotty.bsky.social · 30/06/2026The structural biology was particularly satisfying. The vaccine-induced antibodies converged on the molecular interactions that had been predicted during immunogen design, providing strong support for the germline-targeting strategy. 140
Prof. Shane Crotty @profshanecrotty.bsky.social · 30/06/2026One of the most rewarding aspects of this project is that solving a difficult vaccine problem also taught us fundamental lessons about adaptive immunity. I am confident many of the immunological findings will have implications well beyond HIV vaccine development. 141
Prof. Shane Crotty @profshanecrotty.bsky.social · 30/06/2026I’m deeply grateful to Bill Schief, lead Schief lab author Jon Steichen, and Crotty lab lead author Patrick Madden. As well as all of our amazing collaborators, trainees, staff scientists, technicians, and everyone who contributed over the past 14 years. @patmadden.bsky.social @lji.org 040
