Manuel Irimia @mirimiam.bsky.social · 05/10/2026Specialized tissues often evolve by repurposing ancestral genes. TS-GE and TS-AS provide two ways to do this: changing how much of a gene is expressed, or which isoform is produced. But are these broadly interchangeable evolutionary solutions? 2/11 100
Manuel Irimia @mirimiam.bsky.social · 05/10/2026To address this, we compared TS-AS and TS-GE across 8 homologous tissues, 20 bilaterian species and 7,178 ancestral gene families, spanning ~700 million years of evolution. 3/11 100
Manuel Irimia @mirimiam.bsky.social · 05/10/2026First, TS-AS and TS-GE affected remarkably similar numbers of genes within species. Neural tissues showed the strongest contribution of both, while muscle was more biased toward TS-AS and testis toward TS-GE. 4/11 100
