Manuel Irimia @mirimiam.bsky.social · 05/10/2026🧬🧬🧬 Very happy to share our new preprint led by Fede Mantica (@fedemantica.bsky.social) on how tissue-specific alternative splicing (TS-AS) and gene expression (TS-GE) evolve across bilaterians! Thread below 🧵 1/11 www.biorxiv.org/content/10.6... 12910
Manuel Irimia @mirimiam.bsky.social · 05/10/2026Specialized tissues often evolve by repurposing ancestral genes. TS-GE and TS-AS provide two ways to do this: changing how much of a gene is expressed, or which isoform is produced. But are these broadly interchangeable evolutionary solutions? 2/11 100
Manuel Irimia @mirimiam.bsky.social · 05/10/2026To address this, we compared TS-AS and TS-GE across 8 homologous tissues, 20 bilaterian species and 7,178 ancestral gene families, spanning ~700 million years of evolution. 3/11 100
