iiinova — where your digital self keeps evolving

Replies

Manuel Irimia @mirimiam.bsky.social · 28/04/2025

⚙️ But what underlies the hyperarousal at the molecular level? Behavioral pharmacology pointed us to elevated cAMP signaling as the likely driver! ● Inhibiting adenylyl cyclases (reducing cAMP) rescued mutant hyperactivity. ● Increasing cAMP in the wild-type phenocopied the mutant. 8/9

130

Manuel Irimia @mirimiam.bsky.social · 28/04/2025

📉 cAMP-targeting pharmacological treatments also mimic and reverse srrm3-dependent transcriptional signatures, including immediate early gene downregulation. Combined with persistent AP1/CREB motif occupancy, it all suggests a longer-term adaptation to sustained neuronal hyperactivity. 9/9

120

Manuel Irimia @mirimiam.bsky.social · 28/04/2025

Thank you to all co-authors and collaborators: @luispiniguez.bsky.social, @tsmullen.bsky.social, Cris Rodriguez, @francoiskroll.bsky.social, @giuliazeta.bsky.social, Jordi Fernandez-Albert, Laia Sancho-Vila, Jon Permanyer, Isaac Bianco, @daniobrain.bsky.social, @jasonrihel.bsky.social.

060