Excited to share our paper out now in @science.org . We (@mpiib-berlin.mpg.de ) engineered single-component signalosomes to dissect the biophysical properties required for signaling. Read on for a cool story on using #synthetic-biology to study #signaling. 1/10
www.science.org/doi/10.1126/...
science.org
Bottom-up reconstruction of functional death fold signalosomes reveals a requirement for polymer stability and avidity
Protein polymer scaffolds composed of death fold (DF) proteins are critical to the formation of signalosomes in immune signaling. The biophysical properties that these polymeric scaffolds require for ...
