Check out this great work by @adambroerman.bsky.social. We describe a general way to control and sense ppi with fast kinetics using #proteindesign. Congrats!
www.biorxiv.org/content/10.1...
biorxiv.org
Design of facilitated dissociation enables control over cytokine signaling duration
Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated[1][1]. Designing the kinetics and dynamics of a system requires, i...
@adambroerman.bsky.socialExcited to join here and announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.
