Pleased to share the work of Mitzy Cowdin and others in our lab showing the requirement for the Hippo pathway kinases Lats1 and 2 for endothelial sensing of hemodynamic flow and for vascular remodeling during embryogenesis 🎉🧪
www.biorxiv.org/content/10.1...
biorxiv.org
Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress
Blood vessels in mammalian embryos develop from initial aggregates of endothelial cell (EC) progenitors, which coordinate the opening and stabilization of central vascular lumens, all while under prog...
