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Zunair Khurram

@zunairkhm.bsky.social
140 followers 550 following 0 posts

PhD Student | Tonkin-Hill Lab 🦠Computational Microbiology, Microbiome Metagenomics🦠

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Reposted by Zunair Khurram
Jim Shaw @jimshaw.bsky.social · 15/09/2026
The sylph metagenome profiler is v1.0.0! sylph-docs.github.io A new DB format + approach --> huge performance gains: GTDB-R232 (200k species) now takes < 5 GB of RAM and ~30s (2GB fq.gz). Huge thanks to @benjwoodcroft.bsky.social and his ongoing performance efforts (github.com/wwood/weebill)
sylph-docs.github.io
Documentation for sylph - ultrafast, precise metagenomic profiling
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Reposted by Zunair Khurram
Gerry Tonkin-Hill @gerrythill.bsky.social · 30/06/2026
Happy to share the latest work from Zunair Khurram, a PhD student in our lab! Zunair has developed a new method, MxSure, to infer within-host substitution rates and transmission thresholds from longitudinal isolate and metagenomic sequencing data. www.biorxiv.org/content/10.6...
biorxiv.org
MxSure: a mixture model for inferring within-host substitution rates and transmission SNP thresholds
Quantifying short-term evolutionary rates of microbial genomes is essential for understanding the processes that shape within-host evolution and for establishing thresholds needed to track transmissio...
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