Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
science.org
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...