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Zeynep Coban-Akdemir

@zhakdemi.bsky.social

9 followers 17 following 10 posts

Mother to Sam Alp, Assistant professor @UTexasSPH Alumni: Izmir Science High School, Sabanci, Harvard, UTHealth, BCM

Posts Replies Media

Reposted by Zeynep Coban-Akdemir

Suja Jagannathan @rnabiologist.bsky.social · 25/12/2025

Excited for this work by Michael Cortazar, an @JagannathanLab Postdoc, to be out as a preprint. So much hard work went into it, but it was well worth it 🤓

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Reposted by Zeynep Coban-Akdemir

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 23/12/2025

www.biorxiv.org/content/10.6...

biorxiv.org

Genomic stop codon scanning reveals quantitative principles of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) degrades transcripts containing premature termination codons (PTCs), critically shaping the disease outcomes of protein-truncating variants. While existing NMD rules...

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Zeynep Coban-Akdemir @zhakdemi.bsky.social · 04/12/2025

Excited to share a genome-wide analysis of pathogenic truncating variants that escape nonsense-mediated decay (NMD) that may produce truncated and/or altered protein tails that are likely to disrupt condensate behavior, contributing to human disease. www.medrxiv.org/content/10.6...

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