Reposted by Zain Munir PatelSri Kosuri @srikosuri.bsky.social · 08/02/2025It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases. 841009846 0
Reposted by Zain Munir Pateltimhughesto.bsky.social @timhughesto.bsky.social · 15/11/2024(1/7) Thrilled to reveal the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for the >300 uncharacterized human transcription factors (TFs) doi.org/10.1101/2024...doi.orgPerspectives on Codebook: sequence specificity of uncharacterized human transcription factorsWe describe an effort (“Codebook”) to determine the sequence specificity of 332 putative and largely uncharacterized human transcription factors (TFs), as well as 61 control TFs. Nearly 5,000 independ... 14111 0
Reposted by Zain Munir PatelIsaac Yellan @downbythebayes.bsky.social · 15/11/2024(1/8) 🚀 Excited to share our findings on a large-scale ChIP-seq assay for 166 previously uncharacterized human transcription factors (TFs) and their roles in both regulatory regions, and more strikingly, the “dark matter” genome. 🌌 doi.org/10.1101/2024....doi.orgExtensive binding of uncharacterized human transcription factors to genomic dark matterMost of the human genome is thought to be non-functional, and includes large segments often referred to as “dark matter” DNA. The genome also encodes hundreds of putative and poorly characterized tran... 39439 0
Reposted by Zain Munir PatelVanja @halfacrocodile.bsky.social · 14/11/2024(1/12) Excited to present the results of the large-scale benchmarking of DNA motif discovery tools using the Codebook data compendium on poorly studied human transcription factors and the Codebook Motif Explorer: dx.doi.org/10.1101/2024..., mex.autosome.org ⬇️. 25525 0
Reposted by Zain Munir PatelAnshul Kundaje @anshulkundaje.bsky.social · 13/11/2024Incredible resource for DNA binding protein specificity from the Codebook consortium. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... Am reading these in detail & will have a lot to say. Stay tuned for thoughts.biorxiv.orgExtensive binding of uncharacterized human transcription factors to genomic dark matterMost of the human genome is thought to be non-functional, and includes large segments often referred to as "dark matter" DNA. The genome also encodes hundreds of putative and poorly characterized tran... 311947 0