Very pleased to finally see this story from my post doc with Bart Vanhaesebroeck out in PNAS - quite a few surprises when modelling drug-like inactivation of PI3K-C2alpha in mice!
www.pnas.org/doi/10.1073/...
pnas.org
Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock | PNAS
The organismal roles of the class II PI3K isoform PI3K-C2α remain poorly understood.
Recent studies have found PI3K-C2α to promote arterial thrombo...