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yoelklug.bsky.social

@yoelklug.bsky.social
81 followers 87 following 7 posts

Postdoc in Carvalho lab, @Dunnshool.bsky.social Oxford, working on lipid droplet biogenesis and membrane proteins. Don't take life too seriously - its your only one.

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yoelklug.bsky.social @yoelklug.bsky.social · 15/03/2025
And it's out! Some nice biochemistry reveals how the yeast Seipin compelx organizes in vivo across LD formation www.biorxiv.org/content/10.1...
biorxiv.org
Organization of the Yeast Seipin Complex Reveals Differential Recruitment of Regulatory Proteins
Lipid droplets (LDs) are neutral lipid storage organelles that emerge from the endoplasmic reticulum (ER). Their assembly occurs in ER regions enriched with seipin which, through its homooligomeric ri...
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yoelklug.bsky.social @yoelklug.bsky.social · 12/02/2025
I am presenting!! Come hear about lipid droplet biogenesis and the protein that makes it all happen, seipin.
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yoelklug.bsky.social @yoelklug.bsky.social · 06/02/2025
Come hear what amazing science is being done by Israeli scientists in Israel and abroad! Oh, and I will also be giving a talk on Lipid droplets!!🤩🤩 www.scienceabroad.org.il/life-science...
scienceabroad.org.il
Life Sciences Symposium 2025 - ScienceAbroad
For details>>
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The Dunn School, Oxford @dunnschool.bsky.social · 31/01/2025
Mentors play such an important role in the career and confidence of budding scientists... Many congratulations to Rebecca and Erik, winners of the first Dunn School Marvellous Mentor Award. Another great initiative by our student association! www.path.ox.ac.uk/news-article...
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@MorieLAB @morielab.bsky.social · 25/01/2025
New from @MorieLAB.bsky.social! Neutral Lipids restrict DNA mobility!! 1. This has important implications for DNA repair in vivo, 2. also in vitro when you measure DNA breaks using the comet assay, beware! 3. And, we provide a fast new protocol overcoming this issue 😍 doi.org/10.1111/boc....
doi.org
Neutral lipids restrict the mobility of broken DNA molecules during comet assays
This study reveals that neutral lipids (NL), naturally present in cells, become trapped within genomic DNA as a consequence of the standard execution of the comet assay, a technique used to measure D...
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Veijo Salo @veijosalo.bsky.social · 19/01/2025
Excited to be giving a talk tomorrow at Karolinska. If anyone is in the area, do come check it out! news.ki.se/calendar/sem...
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Dr. Sarah Parcak @indyfromspace.bsky.social · 31/12/2024
In ancient Egypt, people drank low alcohol beer and wine to avoid the parasites in "raw water." The old graves, which I excavate, are full of children who died from diseases we now can vaccinate against. You are ghouls for promoting this garbage.
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Colin Millar @colinmillar.bsky.social · 22/12/2024
Tonight is the ‘lluvia de peluches’ at Real Betis. The annual tradition of stuffed toys thrown on to the pitch and collected for disadvantaged children ahead of Christmas. An estimated 15,000 toys are expected for collection.
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yoelklug.bsky.social @yoelklug.bsky.social · 22/12/2024
You are all alone
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yoelklug.bsky.social @yoelklug.bsky.social · 20/12/2024
Wonderful use of science www.nature.com/articles/s42...
nature.com
The origins of the Guinness stout yeast - Communications Biology
A genomic analysis of 22 S. cereviseae yeast strains used in beer brewing suggest that yeast used to brew Guinness form a distinct evolutionary sub-clade, and that the modern-day Guinness yeast is clo...
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Journal of Cell Science @jcellsci.bsky.social · 18/12/2024
Nikita Sergejevs, Pedro Carvalho and colleagues find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...
Proposed model of CYP51A1 recognition by SPP. In cells, the lanosterol demethylase CYP51A1 can exist in two distinct conformations, with only one conformation being recognized for membrane protein quality control. The early recognition event by SPP consists of an N-terminal cleavage within the AH of the substrate. This generates a truncated version of CYP51A1 that is subsequently recognized by the RNF185–MBRL E3 ubiquitin ligase complex, extracted from the ER membrane and degraded by the cytosolic proteasomes. APH, amphipathic helix.
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