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yanchen.bsky.social

@yanchen.bsky.social
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Reposted by @yanchen.bsky.social
Vallance Lab @brucevallance.bsky.social · 12/02/2026
🚨NEW FINDINGS! In the age of personalized medicine, we find that biopsy-derived organoids from ulcerative colitis patients show impaired mucus and epithelial barriers, mimicking patient pathologies and providing a platform to test new drugs to repair these barriers. academic.oup.com/ibdjournal/a...
academic.oup.com
Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients
AbstractBackground. The inflammatory bowel disease (IBD) ulcerative colitis (UC) is characterized by colonic mucosal inflammation and barrier dysfunction.
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Reposted by @yanchen.bsky.social
Vallance Lab @brucevallance.bsky.social · 09/05/2025
New paper from our lab! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. 🧫🦠https://pmc.ncbi.nlm.nih.gov/articles/PMC12054374/
pmc.ncbi.nlm.nih.gov
Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. F...
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