Reposted by @yanchen.bsky.social
🚨NEW FINDINGS! In the age of personalized medicine, we find that biopsy-derived organoids from ulcerative colitis patients show impaired mucus and epithelial barriers, mimicking patient pathologies and providing a platform to test new drugs to repair these barriers. academic.oup.com/ibdjournal/a...
academic.oup.com
Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients
AbstractBackground. The inflammatory bowel disease (IBD) ulcerative colitis (UC) is characterized by colonic mucosal inflammation and barrier dysfunction.