New paper out! We show that SARS-CoV-2 PLpro can be inhibited in a substrate-selective manner, preferentially blocking deISGylation over viral polyprotein processing. Computational modelling suggests a mechanism for the observed substrate selectivity.
chemistry-europe.onlinelibrary.wiley.com
Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates
The SARS-CoV-2 papain-like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins...
