iiinova — where your digital self keeps evolving

wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 21/09/2026

The Earlier You Know, The More You Can Do: A Dementia Diagnosis Matters. Early diagnosis opens doors to care and support. 💗 #DementiaDiagnosisMatters #AlzheimerDiagnosisMatters #EarlyDiagnosisMatters #WorldAlzMonth

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 16/09/2026

🧠 Pain is not only a sensory signal. In mice, aversive states activated an mPFC–PBN pathway and increased mechanical and thermal hypersensitivity. Inhibiting it reduced both effects, revealing a cortical–brainstem link between emotion and pain. doi.org/10.1038/s420... #neuroscience #neuroskeye

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 08/09/2026

📄 A neuron-by-neuron tour of how the fruit-fly brain transforms retinal input into feature-biased pathways while preserving fine spatial maps. www.cell.com/cell/fulltex...

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 08/09/2026

🪰 Vision is not a straight line from eye to brain. A neuron-by-neuron map of the male fruit-fly brain shows visual signals spreading broadly, then converging in regions tuned to particular features—while fine spatial maps persist deep in the central brain. A beautiful wiring map. #Neuroscience #art

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 04/09/2026

🪰 The first complete male fruit-fly CNS connectome maps 166,700 neurons at synaptic resolution. Most sensory and motor wiring is shared with females; sex-specific circuits cluster in higher-order centers, with 289 male-specific, 71 female-specific and 138 dimorphic neuron types. #art #neuroskyence

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 02/09/2026

🧬 DDIAS protects DNA during cell division and supports brain development. It shields single-stranded DNA during mitosis. When lost, neural progenitor cells accumulate damage in human organoids and zebrafish, linking genome stability to neurodevelopment. #Neuroscience #Genetics #BrainDevelopment

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 01/09/2026

🧠 The brain's 'task-negative' network isn't off when you focus - the 'switching' network isn't just a switch. A scoping review of 81 papers argues the Triple Network Model needs updating: brain networks are dynamic, context-dependent, and heterogeneous across atlases. #Neuroscience #BrainNetworks

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 31/08/2026

🐟 Even a fish brain may organize senses hierarchically. In zebrafish, a thalamocortical-like pathway carries visual and vibrational signals to the pallium, where neurons range from sensory-specific to multimodal responses. A possible shared principle across vertebrates. #Neuroscience #neuroskyence

Diagram of the zebrafish brain showing a thalamocortical-like pathway carrying visual and vibrational information to the pallium, where sensory-specific and multimodal neurons form a hierarchical processing network.

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 28/08/2026

🧠 Cortical shape may help decide which regions connect. A neural-field model based on geometric eigenmodes reproduced connectome patterns across humans, chimpanzees, macaques, marmosets and mice. A model-based clue, not proof of causation. #neuroscience #cell #art #brain #biology #neuroskyence

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 28/08/2026

Autism risk may converge in protein networks, not just genes. Mapping 100 risk genes found 1,800+ interactions, 87% previously unreported. Patient mutations rewired links and altered neurodevelopment in organoids. Mechanistic work, not a treatment. #neuroskyence #Neuroscience #Science #art

Visual summary of an autism protein-interaction network. The diagram shows how risk proteins converge in shared complexes and how patient-derived mutations can rewire interactions, including FOXP1–FOXP4, with consequences for cortical neurodevelopment.

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 25/08/2026

Older mice did not simply respond more slowly-they were less consistent. Across 18,000 neurons in 16 brain regions, ageing increased neural variability and weakened noise-quenching after stimuli. Mouse data, but a clue to cognitive ageing. #art #Neuroscience #neuroskyence

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 25/08/2026

I’m in love with this sentence: “One of the most underrated skills you can learn is the ability to ignore your mood and stick with the plan.”

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 24/08/2026

The skull may hide an immune hub we never noticed. Cranial bone marrow contains lymph-node-like zones that train immune cells for the brain. In mice with glioma, scalp stimulation improved survival. Human marrow shows the same cells, though this is early. #neuroskyence #Neuroscience #art #immune

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 21/08/2026

🚨BREAKING: Science confirms that brain cells are influenced by our self-talk. #neuroskyence #Neuroscience #art #photography #ai

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 20/08/2026

🧠 Brain networks are not static maps. JIN invites work on the temporal, frequency-specific, and directed dynamics of large-scale brain networks in health and disease. Guest Editor: Prof. Dr. Amedeo D'Angiulli Deadline: 31 Dec 2026 www.imrpress.com/journal/JIN/... #Neuroscience #BrainNetworks

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 19/08/2026

🧠 One ADP signal, opposite cardiovascular effects? This review maps P2Y receptors in neurovascular circuits: P2Y1 in vasodepressor pathways, P2Y12/P2Y13 in sympathetic cardiac control. Rat evidence. #Neuroscience #CardiovascularResearch #PurinergicSignaling #art #photography

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 18/08/2026

Microglia may age because ancient viral DNA wakes up. In mice, losing DAXX let endogenous retroviruses reactivate, driving inflammation and senescence. A striking epigenetic route to brain aging, though the causal work is preclinical. #blues #art #photography #neuroscience #microglia

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 14/08/2026

The first comprehensive map of the human vagus nerve — thousands of fibers traced from brainstem to every major organ. Precise vagus stimulation could treat epilepsy, stroke, inflammatory diseases. A black box finally has coordinates. www.science.org/content/arti... #Neuroscience #VagusNerve

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 14/08/2026

A "relief valve" for the aging brain: nasal AAV-VEGF-C expands downstream lymphatic drainage, restoring CSF outflow. Elegant in mice; glymphatic clearance is an evolving Alzheimer's frontier. Human translation is the open question. www.cell.com/cell/fulltex... #Neuroscience #Glymphatic #ADResearch

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 11/08/2026

🧐 Researchers with the most impact report lower wellbeing — the overwork trap. The happy ones had stability + meaningful work, not grinding. Working in publishing, this hits close to home. 💪Your wellbeing is part of your science. #AcademicMentalHealth #PhDLife academic.oup.com/rev/article/...

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 10/08/2026

Happy International Cat Day 🐱💕 Proof that the best stress-relief intervention is a cat sitting on your keyboard. #InternationalCatDay #CatsOfBluesky

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 06/08/2026

The primitive streak is where an embryo starts organizing its body plan — head from tail, left from right, the very first axis of being human. The twist: they rebuilt it using stem cells + extra-embryonic cells (amniotic ectoderm, trophoblast, mesoderm), with no actual embryo involved.

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wirepulleroo · Academic Publishing @wirepulleroo.bsky.social · 05/08/2026

Scrolling bioRxiv and found a fresh one 🧠 New preprint packed levodopa into DNA nanocages for Parkinson's zebrafish — tremors eased, swimming steadied, damage backed off. Early days, it's a fish. But DNA cages into a failing brain? Still feels sci-fi. doi.org/10.64898/202...

AFM Images of TDs and
TD:Levodopa conjugates, scale bar is 500nm

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