Emmerson et al. demonstrate that the CXCR3-CXCL10 chemokine signaling pathway is important for brain-infiltrating T cells in tau-mediated neurodegeneration. Blocking CXCR3 reduces T cell entry and pro...

APOE4 causes a pericyte-to-myofibroblast transition that promotes cerebrovascular fibrosis and perivascular amyloid accumulation. TGF-β inhibition reverses this pathological remodeling and thus presen...

Chen et al. identify anterior zona incerta aZIT neurons as key drivers of compulsive binge eating. Intermittent high-fat-diet exposure increases GABAergic aZIT neuronal excitability, thus enhancing me...

Glioma-derived guanidinoacetate depolarizes neighboring neurons through γ-aminobutyric acid (GABA) A receptors, and depleting this metabolite reduces both neuronal activity and glioma growth.

This study shows that the brain arises from two distinct progenitors: one forms the forebrain and midbrain, whereas the other generates the hindbrain. These insights enable the generation of human hin...

Nature - Inflection points and transitions in Alzheimer’s disease

Lab-grown organoids wire into mice missing a key part of their brain, offering a new way to test drugs for developmental conditions.

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that co...

WashU Medicine researchers reduced Alzheimer’s-like neurodegeneration in mice by preventing immune cells from traveling to the brain.

Neurodegenerative diseases (NDDs) are closely linked to physiological conditions such as oxidative stress, neuroinflammation, neuronal cell death, and proteostatic failure, all of which are associated...

Chen et al. show that reduced brain glucose metabolism and pathological Tau cooperate to induce neuronal death through necroptosis. By identifying a p-Tau-RIPK1 signaling hub and its regulation by A20...

Human brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, following human-specific endogenous programs,...

How early-career researchers can strengthen their track record, boost their research proposal and assess institutional fit.

Nature - Somatic mutations reveal the ontogeny of microglia in human aging

Study of mitochondria suggests new treatment strategy for Alzheimer’s and other diseases

The ResidencyRL framework trains AI agents using online multi-turn reinforcement learning in simulated clinical environments, achieving marked improvements in diagnostic accuracy, management...

A new project is using artificial intelligence to detect an older-than-expected ‘brain age’ from sleep signals.

The ability to detect and respond to threat signals in the environment, including those conveyed by the distress of a familiar social partner, is fundamental to survival and disrupted in a range of ne...