Reposted by Will TownesGennady Gorin @goringennady.bsky.social · 09/03/2026The empty drops you threw out in your single-cell RNA sequencing analysis might be hiding mysterious things 👀 check out our bioRxiv preprint! The empty drops do not contain cells. Yet we can still use them to learn interesting things about biology and technology. 1/ 287
Will Townes @willtownes.bsky.social · 11/10/2025Tenure track job opportunity in our department! www.cmu.edu/dietrich/sta... #statisticscmu.eduOpen Position: Assistant Professor of Statistics & Data Science - Statistics & Data Science - Dietrich College of Humanities and Social Sciences - Carnegie Mellon UniversityThe Department of Statistics & Data Science invites applications for a tenure track position at the rank of Assistant Professor starting in Fall 2026. 032
Will Townes @willtownes.bsky.social · 29/09/2025Are you interested in concentration inequalities? Curious about whether there is a middle ground between subexponential and subgaussian bounds? Want to know how this all interacts with exponential tilting? Then check out my new paper recently published in TMLR: openreview.net/forum?id=BQB...openreview.netExponential tilting of subweibull distributionsThe class of subweibull distributions has recently been shown to generalize the important properties of subexponential and subgaussian random variables. We describe alternative characterizations of... 000
Will Townes @willtownes.bsky.social · 26/08/2025Thoughts on peer review: willtownes.github.io/blog/2025/08...willtownes.github.ioresearch profile and technical blog 000
Reposted by Will TownesJames Munday @jdmunday.bsky.social · 09/06/2025We have a new preprint 📝 *Post-sampling degradation of viral RNA in wastewater impacts the quality of PCR-based concentration estimates* Now on bioRxiv doi.org/10.1101/2025... with @tanjastadler.bsky.social, trj2.bsky.social, Christoph Ort and othersdoi.orgPost-sampling degradation of viral RNA in wastewater impacts the quality of PCR-based concentration estimatesSuccessful wastewater-based infectious disease surveillance programs depend on regular, reliable molecular detection of nucleic acids in municipal wastewater systems. This process is challenged by the... 193
Will Townes @willtownes.bsky.social · 21/07/2025Anyone else having trouble connecting to github due to a "potential security issue"? 100
Will Townes @willtownes.bsky.social · 01/07/2025Benchmarking study of single-cell feature selection finds deviance to be an effective criterion: doi.org/10.1093/bib/... . Try it yourself with our ( @kstreet.bsky.social @stephaniehicks.bsky.social @davi1893.bsky.social ) scry package @bioconductor.bsky.social : doi.org/doi:10.18129... #genomicsdoi.orgCharacterizing efficient feature selection for single-cell expression analysisAbstract. Unsupervised feature selection is a critical step for efficient and accurate analysis of single-cell RNA-seq data. Previous benchmarks used two d 0122
Will Townes @willtownes.bsky.social · 03/06/2025Currently teaching data science to CMU students in beautiful Monteverde, Costa Rica! Students are working with real data from community partners: eg, permitting for new construction, flow rates from springs that supply drinking water, bell bird calls, and macroinvertebrate water quality indicators 000
Will Townes @willtownes.bsky.social · 14/03/2025Overview of infectious disease forecasting and our Delphi research group @cmu.edu by Roni Rosenfeld: boxcast.tv/view/opening... (start at 20 min mark) delphi.cmu.eduboxcast.tvOpening Session AMIA 2025 Informatics Summit 010
Will Townes @willtownes.bsky.social · 31/01/2025@epigenci.bsky.social makes a pretty convincing case for pseudobulk (as opposed to GLMMs) in multi-sample single cell studies here: doi.org/10.1093/bioi... . #bioinformaticsdoi.orgPseudobulk with proper offsets has the same statistical properties as generalized linear mixed models in single-cell case-control studiesAbstractMotivation. Generalized linear mixed models (GLMMs), such as the negative-binomial or Poisson linear mixed model, are widely applied to single-cell 0102
Will Townes @willtownes.bsky.social · 28/01/2025Very proud of CMU Statistics & Data Science PhD candidate Gabrielle Thivierge who just passed her thesis proposal! "Methods for performing and evaluating infectious disease forecasting and nowcasting". Check out her first paper here: arxiv.org/abs/2408.12722arxiv.orgDoes Spatial Information Improve Influenza Forecasting?Seasonal influenza forecasting is critical for public health and individual decision making. We investigate whether the inclusion of data about influenza activity in neighboring states can improve poi... 010
Will Townes @willtownes.bsky.social · 01/11/2024Cool #Rstats package for wastewater-based #epidemiology adrian-lison.github.io/EpiSewer/ #infectiousdiseaseadrian-lison.github.ioEstimate Epidemiological Parameters from Wastewater MeasurementsWhat the package does (one paragraph). 031
Will Townes @willtownes.bsky.social · 29/08/2024Spatiotemporal variability of the pepper mild mottle virus (PMMoV) biomarker in #wastewater : a new preprint with CMU Stats PhD student Anna Rosengart and @wastewaterscan.bsky.social collaborators arxiv.org/abs/2408.12012arxiv.orgSpatio-Temporal Variability of the Pepper Mild Mottle Virus...Since the start of the coronavirus-19 pandemic, the use of wastewater-based epidemiology (WBE) for disease surveillance has increased throughout the world. Because wastewater measurements are... 010
Will Townes @willtownes.bsky.social · 29/07/2024Mixed Poisson distributions are useful in modeling count data (eg negative binomial is Poisson mixed with gamma). But did you know the mixing distribution can actually include negative values? Read all about it here: arxiv.org/abs/2407.17614 #probability #statisticsarxiv.orgMixed Poisson families with real-valued mixing distributionsMixed Poisson distributions provide a flexible approach to the analysis of count data with overdispersion, zero inflation, or heavy tails. Since the Poisson mean must be nonnegative, the mixing... 021
Will Townes @willtownes.bsky.social · 18/07/2024New preprint: "Exponential tilting of subweibull random variables". arxiv.org/abs/2407.11386 Comments welcome! #probability #statisticsarxiv.orgExponential tilting of subweibull distributionsThe class of subweibull distributions has recently been shown to generalize the important properties of subexponential and subgaussian random variables. We describe alternative characterizations... 000
Will Townes @willtownes.bsky.social · 18/03/2024If I am interested in prediction intervals and am comfortable with a parametric model, what are the pros and cons of conformal prediction as opposed to bootstrapping? 130