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WikiPathways

@wikipathways.fosstodon.org.ap.brid.gy
44 followers 3 following 59 posts

WikiPathways is an open, public platform dedicated to the collection and curation of biological pathways by and for the scientific community 🌉 bridged from ⁂ fosstodon.org/@wikipathways, follow @ap.brid.gy to interact

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Reposted by WikiPathways
BioHackrXiv @biohackrxiv.fediscience.org.ap.brid.gy · 20/09/2026
"DBCLS BioHackathon 2026 report: Extending TogoMCP beyond RDF Portal while making its schema guides check their own answers" doi.org/10.37044/osf.io/t25ng_v1 #biohackathon #mcp #rdf #BH26JP #qlever "In the first six days of the event we published eleven releases (v2.12.2 to v2.20.0) […]
fediscience.org
Original post on fediscience.org
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Reposted by WikiPathways
BioHackrXiv @biohackrxiv.fediscience.org.ap.brid.gy · 19/09/2026
"DBCLS BioHackathon 2026 report: QPX: Pathway analysis environment for non-model organisms" doi.org/10.37044/osf.io/7egfm_v1 #biohackathon #pathway #bioinformatics #BH26JP #rice #arabidopsis "We report progress on Quest for Pathways with eXpression […] [Original post on fediscience.org]
Part of Figure 1: Arabidopsis-to-rice pathway liftover: whole pathway and N-module detail.

The selection shows the "PathLift" arrow between the original Arabidopsis pathway and the new, pathlifted Oryza sativa pathway. They highlighted a complex with a purple line, which is detailed in the bottom part of the original figure.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 13/09/2026
RE: social.edu.nl/@egonw/11726489458281… go ask them questions! #EUROTOX2026
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 10/09/2026
September 2026 WikiPathways update: 53 edits in 142 pathways by 3 contributors, including many new molecular AOP pathways. More news at github.com/wikipathways/wikipathway… www.wikipathways.org/index.php/Down… #bioinformatics #openscience #opensource
github.com
2026 September Release and other news · wikipathways wikipathways-help · Discussion #242
The 2026 September Release is available for download. This release has 53 edits in 142 pathways by 3 contributors, including 3 new pathways. Discussions Depositing generated molecular AOP pathways ...
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Reposted by WikiPathways
Dept of Translational Genomics @tgx-um.social.edu.nl.ap.brid.gy · 04/09/2026
Dr Susan Coort was keynote at the NuGOweek 2026 this week: "Connecting the dots: pathways and networks in nutrition research" nugo2026.pan.olsztyn.pl #nutrigenomics #NuGOweek #wikipathways Find more about her research here […] [Original post on social.edu.nl]
Coort on stage in front of one of her slides, showing information about the WikIpathways project.

Photo: All rights reserved, Meike Bünger, Health-RI / ELIXIR-NL.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 27/08/2026
Check out "PlantMetWiki: a FAIR knowledge graph for plant metabolic pathway cross-species representation and integration " by Elena del Pup et al.: doi.org/10.64898/2026.07.22.733699 This preprint describes a project outside the WikiPathways database […] [Original post on fosstodon.org]
Figure 5: Metabolite cross-reference coverage: direct BridgeDb mapping complements InChIKey federation. (A) How the 4,577 wp:Metabolite nodes resolve to external chemical databases: 3,198 (69.9%) carry ≥1 BridgeDb-materialised cross-reference and are resolvable directly in the graph without federation; 1,207 (26.4%) carry only an InChIKey and remain reachable through query-time federation to Wikidata (wdt:P235) and other InChIKey-indexed resources; 172 (3.8%) have neither. (B) Cross reference coverage per database, comparing the single PlantCyc source identifier each metabolite carries with the BridgeDb-added wp:bdb* cross-references. [..]
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 20/08/2026
Fwd: "Treat biological databases as infrastructure, not projects" doi.org/10.1038/d41586-026-02575-5 Very relevant to us too!
nature.com
Treat biological databases as infrastructure, not projects
Letter to the Editor
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 11/08/2026
August 2026 WikiPathways update: 16 edits in 8 pathways by 3 contributors in and 3 new pathway. More news at github.com/wikipathways/wikipathway… www.wikipathways.org/index.php/Down… #bioinformatics #openscience #opensource
github.com
2026 August Release and other news · wikipathways wikipathways-help · Discussion #239
The 2026 July Release is available for download. This release has 16 edits in 8 pathways by 3 contributors in and 3 new pathway. Other news Press, articles, blog posts, videos Preprint: PlantMetWik...
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 10/07/2026
July 2026 WikiPathways update: 31 edits in 5 pathways by 4 contributorsin and 1 new pathway. More news at github.com/wikipathways/wikipathway… www.wikipathways.org/index.php/Down… #bioinformatics #openscience #opensource
github.com
2026 July Release and other news · wikipathways wikipathways-help · Discussion #236
The 2026 July Release is available for download. This release has 31 edit in 5 pathways by 4 authors, and 1 new pathways. Other news Press, articles, blog posts, videos Altantic cod is a new organi...
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 29/06/2026
you can now share pathways with a few clicks on Mastodon (thx to the PR by @larsgw) Click on the orange arrow bottom left of the pathway figure, click the Mastodon logo, and get a window to share on your fediverse server #fediverse #openscience #mastodon #biology
Screenshot of the https://www.wikipathways.org/pathways/WP5638 webpage, after clicking the orange "share" button (visible as the curve arrow mid left of the screenshot, right of the "download" icon). In front of it, it shows the WikiPathways "share" dialog with three URLs to share the page, but also a row of five logos for sharing to Facebook, Mastodon, Whatsapp, LinkedIn, and email (in that order). In front of all that, a second browser window with the Mastodon "Share to Mastodon" window, with the example text to share (defaulting to here to "Check out this pathway from @wikipathways@fosstodon.org: Fatty acid beta-oxidation https://www.wikipathways.org/instance/WP5638"), and a paragraph asking for "Your Mastodon Domain", and a big "Continue to Mastodon" button.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 24/06/2026
Google Scholar now found >500 citations to the WikiPathways 2024 paper: scholar.google.com/scholar?oi=bibs&… There are some interesting titles in that list of articles!
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 10/06/2026
June 2026 WikiPathways release: 10 edits by 5 contributors, with 2 new pathways. More news at github.com/wikipathways/wikipathway… #openscience
github.com
2026 June Release and other news · wikipathways wikipathways-help · Discussion #233
The 2026 June Release is available for download. Still not back at our regular activity, this release has 10 edit by 5 authors, and two new pathways. Other news Press, articles, blog posts, videos ...
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 07/06/2026
a new R package, PinPath, allows mapping experimental data onto pathways, using just R: doi.org/doi:10.18129/B9.bioc.PinPath bioconductor.org/packages/devel/bio… #openscience #bioinformatics #bioconductor
Example SVG from the WikiPathways vignette of the PinPath packages with data mapped onto a pathway. The pathways is from a publication from 2022: https://doi.org/10.3389/fonc.2022.849640 "A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma"

Genes/Proteins are colored by up- or downregulation, blue and red.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 01/05/2026
today we phased out the WikiPathways Classic website. This website has served the project for many years and was based on the @mediawiki software for the account administration features, extended with feature to display and edit pathways. Following upstream releases turned out costly and several […]
fosstodon.org
Original post on fosstodon.org
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 12/04/2026
April 2026 WikiPathways update: 71 edits by 7 contributorsin and 2 new pathways the last month. More news at github.com/wikipathways/wikipathway… Accessible via #webservices, #rstats, #pathvisio and #cytoscape. www.wikipathways.org/index.php/Down… […]
fosstodon.org
Original post on fosstodon.org
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Reposted by WikiPathways
WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 05/04/2026
Milestone! "To date, 902 pathways have been cited a total of 3018 times" www.wikipathways.org/browse/citedin… #biology #openscience
Screenshot of part of the linked webpage. It shows a list ("Pathways Cited in the Literature"), stating the fact listed in the main post, and then an alphabetically sorted list of pathways by name (but also with WP identifier), and for each, as sublist, DOI / PubMedCentral ID badges for the articles that cite that pathway. The screenshot shows that the first 10 pathways in the list of 1, 2, or 3 citations.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 05/04/2026
Milestone! "To date, 902 pathways have been cited a total of 3018 times" www.wikipathways.org/browse/citedin… #biology #openscience
Screenshot of part of the linked webpage. It shows a list ("Pathways Cited in the Literature"), stating the fact listed in the main post, and then an alphabetically sorted list of pathways by name (but also with WP identifier), and for each, as sublist, DOI / PubMedCentral ID badges for the articles that cite that pathway. The screenshot shows that the first 10 pathways in the list of 1, 2, or 3 citations.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 03/04/2026
@Marvin upgraded our SPARQL interface. It now show a title and a description, and making it easier to navigate the example queries: sparql.wikipathways.org (maybe do a hard reload) #openscience #bioinformatics
Screenshot of the linked SPARQL endpoint interface. It shows three main panels below a title bar (which includes the endpoint URL). One panel shows the title, description, and SPARQL query currently being "edited". The right-hand side panel shows a list of queries, now with easier to read query names. The bottom panel is still the results table. The query used is the one listing all authors, sorted descending by the number of pathways they initiated. For each author, the number of pathways, their name, ORCID, and WikiPathways account page is listed.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 01/04/2026
hi all, as promised (and really no joke), we are today shutting down the Classic website. Step 1: take the webservice offline (done)
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 19/03/2026
hi, scrapers have been crawling the classic website for more than half a year now. We are trying to keep it at manageable levels, but our options are running out. So, right now, we had to enable the "under attack" mode of @cloudflare This likely breaks the webservice... but we first need to […]
fosstodon.org
Original post on fosstodon.org
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 10/03/2026
March 2026 WikiPathways update: 45 edits by 5 contributors in the last month. More news at github.com/wikipathways/wikipathway… Accessible via #webservices, #rstats, #pathvisio and #cytoscape. Supported by #awsopen […]
fosstodon.org
Original post on fosstodon.org
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Reposted by WikiPathways
WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 25/02/2026
Important: WikiPathways Technical Transition - Action Required for Some Users Dear WikiPathways Community, Effective April 1st, 2026, we will begin taking major steps toward retiring the classic WikiPathways backend as we complete our migration to our GitHub-based infrastructure. 1/ […]
fosstodon.org
Original post on fosstodon.org
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 25/02/2026
Important: WikiPathways Technical Transition - Action Required for Some Users Dear WikiPathways Community, Effective April 1st, 2026, we will begin taking major steps toward retiring the classic WikiPathways backend as we complete our migration to our GitHub-based infrastructure. 1/ […]
fosstodon.org
Original post on fosstodon.org
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Reposted by WikiPathways
Egon Willighagen @egonw.social.edu.nl.ap.brid.gy · 22/02/2026
new blog post: "Where do the WikiPathways come from?" chem-bla-ics.linkedchemistry.info/2… doi.org/10.59350/6smn2-ah530 "We can see who the 8 people are who contributed to this pathway ..], and […] [Original post on social.edu.nl]
Screenshot from the blog post, showing the WikiPathways SPARQL interface with a SPARQL query in the text box in the top left, on the right hand side a folder structure with other examples SPARQL queries, and in the bottom a table with results from the text box SPARQL query. The table shows a list of eight authors of the pathways with identifier WP10. It shows their names, there profile pages, and for some of them, their ORCID identifiers.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 12/02/2026
Dear WikiPathways #Community, We want to share an important update about our WikiPathways leadership. ✨After nearly 20 years of dedication since co-founding WikiPathways in 2007, the Gladstone team, including Alexander Pico and Kristina Hanspers, are transitioning away from their leadership […]
fosstodon.org
Original post on fosstodon.org
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 12/02/2026
February 2026 WikiPathways update: 95 edits by 9 contributorsin the last month. More news at github.com/wikipathways/wikipathway… Accessible via #webservices, #rstats, #pathvisio and #cytoscape. Supported by #awsopen […]
fosstodon.org
Original post on fosstodon.org
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Reposted by WikiPathways
Egon Willighagen @egonw.social.edu.nl.ap.brid.gy · 21/01/2026
hi, if you are using the #WikiPathways (@wikipathways) RDF, please send me a ping. In the coming months, changes are going to happen. To fix and improve some old designs, to add new functionality (like in the January release with more direct IRI links to other knowledge graphs). Some things may […]
social.edu.nl
Original post on social.edu.nl
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 11/01/2026
January 2026 WikiPathways update: 134 edits by 3 contributorsin the last month. More news at github.com/wikipathways/wikipathway… Accessible via #webservices, #rstats, #pathvisio and #cytoscape. Supported by #awsopen […]
fosstodon.org
Original post on fosstodon.org
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Reposted by WikiPathways
BioHackrXiv @biohackrxiv.fediscience.org.ap.brid.gy · 06/01/2026
"QPX: Pathway analysis environment" doi.org/10.37044/osf.io/m37f2_v1 "Building on our work at DBCLS BioHackathon 2023 (BH23), where we introduced QPX andpromoted pathway modeling with WikiPathways (Pico et al., 2008) using PathVisio (Kutmon etal […] [Original post on fediscience.org]
Screenshot of the linked BioHackrXiv preprint, showing the top half of a preprint PDF page, showing the BioHackrXiv logo from the template, a table at the top listing a Arabidopsis thaliana pathway, and below that part of Figure 1 showing a "[p]athway diagram for for Caffeine synthesis inCoffea arabica.  This diagram is already published in WikiPathways at https://www.wikipathways.org/pathways/WP5586.html".
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 21/12/2025
December 2025 WikiPathways release: 840 edits by 8 contributors and 9 new pathways. Accessible via #webservices, #rstats, #pathvisio and #cytoscape. www.wikipathways.org/#download #bioinformatics #elixirnl
WikiPathways WP5609: Key metabolic pathways in melanoma, glycolytic pathway, TCA cycle, glutamine metabolism, and oxidative phosphorylation, with potential therapeutic targets and inhibitors. Inhibitors targeting critical metabolic nodes are outlined in teal. This pathway is based on Figure 1 in Shen et al.WikiPathways WP5606: Cis- and trans-acting regulators shape gene expression within the β-globin cluster. The LDB1 complex (LDB1/LMO2/GATA1/TAL1) binds both the locus control region (LCR) and globin promoters, promoting chromatin looping to activate these genes—interactions that may be influenced by cis-acting variants linked to HbS haplotypes. Across the HBB gene cluster and its surrounding regions, BCL11A and ZBTB7A (LRF) binding sites are present, represented by red and blue stars. Each of these transcription factors recruits its own NuRD complex. MYB regulates HbF expression directly and also indirectly through KLF1 and BCL11A. Repression of the HbF genes is indicated by dashed lines. Inspired by figure 1 in Habara et al. (2017).WikiPathways WP5604: This pathway shows the molecular pathophysiology of sickle cell disease. (A) A single–nucleotide variant in the β-globin gene replaces glutamic acid with valine at position 6 of the β-globin chain. Upon deoxygenation, the resulting hemoglobin S (HbS) molecules polymerize into rigid fibers, driving erythrocyte sickling (clockwise). (B) Sickled cells cause impaired blood rheology and enhanced adhesion of erythrocytes to neutrophils, platelets, and the endothelium, leading to slowed or obstructed microvascular flow – called vaso-occlusion. Vaso-occlusion in turn promotes ischemia-reperfusion (I-R) injury (clockwise). (C) HbS polymer formation also leads to red cell membrane damage and hemolysis (counterclockwise), releasing cell-free hemoglobin (Hb) into circulation. Oxygenated Hb (Fe²⁺) contributes to endothelial dysfunction by consuming nitric oxide (NO) and producing nitrate (NO₃⁻) and methemoglobin (Fe³⁺). Hb can also undergo Fenton chemistry with H₂O₂, generating hydroxyl radicals (•OH) and additional methemoglobin. Methemoglobin (Fe³⁺) can degrade and release cell-free heme (counterclockwise), a potent erythrocyte-derived DAMP. (D) ROS production, TLR4 activation, NET formation, release of tissue- or cell-derived DAMPs, extracellular DNA, and other yet-undefined mediators generated by cell-free heme or I-R injury can induce sterile inflammation by activating the inflammasome in vascular and immune cells, leading to IL-1β release.WikiPathways WP5607: Erythroid lineage cell differentiation transitions from hematopoietic stem cells (HSCs) through successive erythroid progenitors – burst-forming unit–erythroid (BFU-E), colony-forming unit–erythroid (CFU-E) – then proerythroblasts (proEB), basophilic erythroblasts (basoEB), polychromatic erythroblasts (polyEB), and orthochromatic erythroblasts (orthoEB), then and ultimately to reticulocytes, pyrenocytes, and mature red blood cells (RBCs). Stage-specific transcription factors (GATA1, GATA2), surface markers (CD34, CD45, CD71, CD235a), the onset of hemoglobin expression, and other factors are also depicted.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 18/12/2025
new paper describing 5 #CAKUT pathways, WP4823, WP4830, WP5052, WP5053, and WP5236: "Here, we develop and describe fully machine-readable, well-annotated pathways to visualize and analyze key events during kidney development." doi.org/10.1016/j.kint.2025.09.032
Figure 3. Subnetworks derived from kidney development pathways, extended with chemical compound information and annotated with the compounds’ usages in humans. (a) Subnetwork showing interactions of known nephrotoxic compounds with kidney development pathway proteins. (b) Herbicidal compounds interacting with kidney development pathway proteins. (c) Chemical compounds binding to or affecting expression of GDNF. AMP, adenosine monophosphate.
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Reposted by WikiPathways
Christian Meesters @rupdecat.fediscience.org.ap.brid.gy · 15/12/2025
@wikipathways @egonw Next attempt. Just using these libs: library(rWikiPathways) library(XML) library(dplyr) library(igraph) library(ggraph) library(ggplot2) Still need to polish and work on the colour scale, though. Honestly? I, considering my workload, I […] [Original post on fediscience.org]
overlay plot of a wikipathway showing over- and under expressed genes in red, resp. blue.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 07/12/2025
got GPML files on @github? Validate them with this action: jobs: test: name: "Validate XSD files" runs-on: ubuntu-latest steps: - name: Checkout uses: actions/checkout@v6 - name: Validate XSD files conform to the specs uses: phpcsstandards/xmllint-validate@v1 with: pattern: "pathways/*.gpml" […]
fosstodon.org
Original post on fosstodon.org
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Reposted by WikiPathways
Christian Meesters @rupdecat.fediscience.org.ap.brid.gy · 05/12/2025
@egonw a few days ago, I updated bumped the #Bioconda package of r-wikipathways to v1.30 . Thank you for this wonderful package! Today, after quite some tinkering, I managed to overly differential expression results. This is not stable code, yet. The […] [Original post on fediscience.org]
Result of an R-Script illustrating downregulation (shades of blue) in a Drosophila pathway. The dataset was small, the results not reliable, the biological interpretation not feasible.
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LIPID MAPS @lipidmaps.bsky.social · 01/11/2025
November’s #LipidoftheMonth is a rare phospholipid with links to ferroptosis lipidmaps.org/updates/lipi...
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 18/11/2025
hi all, as you may have heard elsewhere, @cloudflare has having some struggling. this affects our websites too. you can monitor their work to restore their status here: www.cloudflarestatus.com
cloudflarestatus.com
Cloudflare Status
Welcome to Cloudflare's home for real-time and historical data on system performance.
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Reposted by WikiPathways
WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 15/11/2025
Hi everyone, we have updated the author and community pages on our website. Authors can now find curation reports for pathways they started, and Communities can find those too. We hope you like it! github.com/wikipathways/wikipathway… #openscience #biology #biocuration
Screenshot of the COVID-19 Community page with the pathways curated by this community, showing thumbnails of 21 pathways along with full title and a curation report badge showing the number of curation events. These are colored by the number of events, mostly yellow (1-2 suggestions) and orange (3-4 suggestions) here.Screenshot of Europe PMC for pathways of the COVID-19 Community page. It shows a few relevant journal articles mentioning specific COVID-19 pathways.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 15/11/2025
Hi everyone, we have updated the author and community pages on our website. Authors can now find curation reports for pathways they started, and Communities can find those too. We hope you like it! github.com/wikipathways/wikipathway… #openscience #biology #biocuration
Screenshot of the COVID-19 Community page with the pathways curated by this community, showing thumbnails of 21 pathways along with full title and a curation report badge showing the number of curation events. These are colored by the number of events, mostly yellow (1-2 suggestions) and orange (3-4 suggestions) here.Screenshot of Europe PMC for pathways of the COVID-19 Community page. It shows a few relevant journal articles mentioning specific COVID-19 pathways.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 12/11/2025
November 2025 WikiPathways update: 686 edits by 6 contributors and 10 new pathways in the last month. Accessible via #webservices, #rstats, #pathvisio and #cytoscape. Supported by #awsopen. www.wikipathways.org/index.php/Down… #bioinformatics #openscience #opensource
New pathway, Caffeine in blood vessels (WP5601). In vascular smooth muscle, caffeine promotes relaxation by inhibiting myosin light-chain kinase (MLCK) through cAMP elevation and activating myosin light-chain phosphatase (MLCP), reducing myosin–actin interaction. As a nonselective adenosine receptor antagonist, caffeine blocks A₁/A₃ receptors (which normally lower cAMP) and A₂A/A₂B receptors (which normally raise cAMP), thereby altering adenylate cyclase activity. In endothelial cells, caffeine increases intracellular Ca²⁺, activating eNOS to produce nitric oxide (NO), which diffuses to smooth muscle and stimulates cGMP signaling, further promoting vasodilation. Inspired by Figure 1 in Kumar and Lipshultz, 2019.New pathway, KCNQ2 and KCNQ3-related epilepsy (WP5599): Processes involved in KCNQ2 and KCNQ3-related epilepsies.New pathways, GABA and glutamate signalling in epileptogenesis (WP5600): This pathway depicts the epileptogenic mechanisms involving GABA and glutamate signaling. It focuses on transporters and channel proteins that modulate action potential dynamics and their interacting partners, highlighting functional alterations that contribute to epilepsy pathogenesis.
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Reposted by WikiPathways
Egon Willighagen @egonw.social.edu.nl.ap.brid.gy · 25/10/2025
just minting some protein identifiers in #wikidata, so that I can link them to literature, and thus enriching @wikipathways qid,P31,P703,Len,Den ,Q8054,Q209089,"""PcCS1""","""guarana protein""" ,Q8054,Q209089,"""PcCS1""","""guarana protein""" ,Q8054,Q209089,"""PcCS""","""guarana protein"""
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 18/10/2025
five new species, five new pathways, five ways caffeine is synthesized: - Theobroma cacao caffeine synthesis (WP5588): www.wikipathways.org/pathways/WP558… - Citrus sinensis caffeine synthesis (WP5589) […] [Original post on fosstodon.org]
Depiction of the caffeine synthesis pathway in Coffea arabica showing a 6-step biosynthesis starting with xanthosine monophosphate, involving 5 proteins.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 12/10/2025
hi all, the domain name is being transferred and the website may not be accessible right now. Hopefully this is solved soon!
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 11/10/2025
October 2025 WikiPathways update: 129 edits by 10 contributors and 5 new pathways in the last month. Accessible via #webservices, #rstats, #pathvisio and #cytoscape. Supported by #awsopen. www.wikipathways.org/index.php/Down… #bioinformatics #openscience #opensource
wikipathways.org
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THIS ACCOUNT IS MOVING @xtaldave.xtaldave.net.ap.brid.gy · 22/09/2025
The rise of ADP-ribose–ubiquitin Ok, this has gone too far. A PTM on a PTM on a PTM on a PTM... www.nature.com/articles/s41594-025-…
nature.com
The rise of ADP-ribose–ubiquitin - Nature Structural & Molecular Biology
Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 12/09/2025
September 2025 WikiPathways update: 261 edits by 6 contributors and 13 new pathways in the last month. Accessible via #webservices, #rstats, #pathvisio and #cytoscape. Supported by #awsopen. www.wikipathways.org/index.php/Down… #bioinformatics #openscience #opensource
wikipathways.org
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Egon Willighagen @egonw.social.edu.nl.ap.brid.gy · 13/08/2025
the new @wikipathways RDF is loaded in the SPARQL endpoint and this includes triples we did not have before, based on the "Cited In" functionality of WikiPathways (see fosstodon.org/@wikipathways/1149254…). So, you can now list all pathways […] [Original post on social.edu.nl]
Screenshot of a table with SPARQL query results of the first linked SPARQL query, with 13 COVID-19 community portal pathways, of which the most cited pathway ("COVID-19 adverse outcome pathway") is cited 13 times, three more cited 10, and a long tail.
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 10/08/2025
August 2025 WikiPathways release: 367 edits by 10 contributors and 26 new pathways. data.wikipathways.org #openscience #biology #pfas
WP5579 shows two lists of PFAS, one found in all sampled humans, the second list in 10-99% of the sampled humans. The description of the pathway writes: "A recent study by the Dutch RIVM found that across The Netherlands seven PFAS are found in every tested human, with an additional nine found in at least 10% of the population. Three of these PFAS were found to be associated to cancer. PFOS, PFHxS, and PFOA were found to be significantly positively associated with testicular germ cell tumors (TGCT) among U.S. Air Force servicemen [PMID:37458713 ]. Data from a 2-year bioassay study on rats did not support a PFOS-related effect on testicular tumors, while serum PFOS concentrations were much higher in magnitude compared to levels reported in the former study [PMID:37751326].  ..."A depiction of WP5633, with the description: "RNA Polymerase II transcription: the preinitiation complex."
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Reposted by WikiPathways
Egon Willigh☮gen 🟥 @egonw.mastodon.social.ap.brid.gy · 08/08/2025
things I am doing this morning: 1. check up on the impact of retracted articles (with @wikidata) 2. curation of @wikipathways pathways The second follows up from work yesterday, going through a long list of pathways on the old website but not on the new […] [Original post on mastodon.social]
2D diagram of the CYP metabolism pathway, with an outdated list of CYP enzymes. The metabolism is drawn as a circular process, involving oxygen, iron ions, and CYP enzymes. It is "homology converted" and can be updated with knowledge from the two references I added today (see the two reply posts).
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 07/08/2025
"We utilized a #Python script with the xml.etree.ElementTree parser module to analyze the WP2877 GPML file from WikiPathways. This script focused on ‘DataNode’ elements to extract the ‘TextLabel’ attribute, assembling a comprehensive list of genes essential to the VDR pathway. After removing […]
fosstodon.org
Original post on fosstodon.org
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WikiPathways @wikipathways.fosstodon.org.ap.brid.gy · 05/08/2025
New release of PFOCR! Over 6,500 new pathway figures added for a total of 116,972. These include 147,974 unique genes across hundreds of species (18,775 human), 7,855 unique ChEBI, and 748 unique disease DOIDs. pfocr.wikipathways.org Using the search […] [Original post on fosstodon.org]
Screenshot of the linked PFOCR website's search results for APOE4, showing 4 (and a half) results, each one with a thumbnail of the pathway on the left, the title of the article, publication year, and a short description.Page of PFOCR where article titles are listed that have been digitized in WikiPathways, along with a badge at the end showing the matching WikiPathways WP identifier. For example, the top item reads:

Regulation of D-secretase in neurodegenerative diseases (2020, Mus musculus,Rattus norvegicus,Homo sapiens,Sar) WikiPathways WP5372
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