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William Fostier

@wfostier.bsky.social
80 followers 100 following 11 posts

Academic Clinical Fellow in Dermatology and Internal Medicine @ Newcastle Hospitals and Newcastle University, UK.

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Reposted by William Fostier
Eric Topol @erictopol.bsky.social · 08/07/2025
Even though they may be seem hard to find, I look for the positive things in life science and medicine every day. You might not know they are occurring by scrolling through the social media platforms.
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William Fostier @wfostier.bsky.social · 28/05/2025
We hope this review will serve as a helpful guide for patients and dermatologists to understand, diagnose, and manage the cutaneous manifestations of Birt-Hogg-Dubé (BHD) syndrome.
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William Fostier @wfostier.bsky.social · 28/05/2025
“Cutaneous fibrofolliculomas and trichodiscomas in Birt-Hogg-Dubé syndrome: a review of therapeutic strategies” is now out in Dermatological Surgery! 🎉 journals.lww.com/dermatologic... A real testament to the BHD patient advocates and @derm-scientist.bsky.social who have championed this work!
journals.lww.com
Cutaneous Fibrofolliculomas and Trichodiscomas in... : Dermatologic Surgery
developing recommendations for surgical treatment. METHODS A literature search was conducted to review cases of BHD associated fibrofolliculomas and trichodiscomas and the role of cryosurgery, cure...
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William Fostier @wfostier.bsky.social · 24/03/2025
This represents a novel systemic therapeutic option for this subtype of metastatic MC and highlights the utility of bioinformatic HRDetect scoring for revealing non-canonical cutaneous malignancies driven by HRD.
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William Fostier @wfostier.bsky.social · 24/03/2025
In this study, we summarize the standard of care for malignant cylindroma and detail the use of WGS to uncover targetable somatic genetic drivers of malignant cylindroma, revealing non-canonical BRCA and homologous repair-deficient tumour amenable to targeting by PARP inhibition.
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William Fostier @wfostier.bsky.social · 24/03/2025
There are no licensed antineoplastic agents available for treatment, leaving patients with limited, empirical options in the event of metastasis.
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William Fostier @wfostier.bsky.social · 24/03/2025
Malignant cylindroma is a rare skin adnexal tumour which can occur in CYLD cutaneous syndrome. This cancer can metastasize with lethal outcomes and has limited genomic characterization due to its rare disease status.
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William Fostier @wfostier.bsky.social · 24/03/2025
CYLD cutaneous syndrome is a rare genodermatosis caused by pathogenic variants in CYLD which results in the development of cylindromas, spiradenomas, and tricoepitheliomas. www.ncbi.nlm.nih.gov/books/NBK555...
ncbi.nlm.nih.gov
CYLD Cutaneous Syndrome
CYLD cutaneous syndrome (CCS) typically manifests in the second or third decade with the appearance of multiple skin tumors including cylindromas, spiradenomas, trichoepitheliomas, and rarely, membran...
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William Fostier @wfostier.bsky.social · 24/03/2025
Credit to supervisors @derm-scientist.bsky.social and @serenanikzainal.bsky.social and co-authors Dr. Koh, Ms. Holt, Dr. Husain, Dr. Namini, Dr. Mathew, Dr. Memari, and Dr. Davies for their hard work on this project 👏🏼 academic.oup.com/ced/advance-...
academic.oup.com
Metastatic malignant cylindroma arising on a background of digenic inheritance of BRCA2 and CYLD pathogenic variants targeted with PARP inhibition
Management of malignant cylindroma, particularly in the case of metastasis, poses a difficult challenge for clinicians and is limited by a lack of randomiz
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William Fostier @wfostier.bsky.social · 24/03/2025
Really pleased to see our original article published this week in Clinical and Experimental Dermatology 🎉 This paper explores the phenotype of a family with co-inheritance of BRCA2 and CYLD PVs resulting in early-onset metastatic malignant cylindroma in one patient with CYLD cutaneous syndrome.
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Reposted by William Fostier
Eric Topol @erictopol.bsky.social · 23/03/2025
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
graph of NIH basisfor new drugs
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William Fostier @wfostier.bsky.social · 12/03/2025
MRCP PACES ✅ onwards to dermatology training! 🎉
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William Fostier @wfostier.bsky.social · 18/02/2025
Grueling few months preparing for the @rcphysicians.bsky.social PACES exam is finally over. Hopeful for a positive outcome! The Spine building @ RCP North was a fitting venue.
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