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WesleyWongLab

@wesleywonglab.bsky.social

We study the physical basis behind how biological systems work at the nanoscale, focusing on the role of force, using single-molecule and nanoscale methods www.wonglab.tch.harvard.edu

Posts Replies Media

WesleyWongLab @wesleywonglab.bsky.social · 19/01/2026

Our light guided molecular patterning method for high-throughput single-molecule studies just published today in Small! Programmable, covalent, multiplexed, accessible. doi.org/10.1002/smll...

doi.org

Light‐Guided Molecular Patterning for High‐Throughput Single‐Molecule Mechanical Characterization

A light-guided molecular patterning method is presented for high-throughput single-molecule characterization. The approach enables scalable and accessible molecular patterning without specialized lit...

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WesleyWongLab @wesleywonglab.bsky.social · 16/01/2026

What better way to start the year then with a deep dive into multiplexed force spectroscopy? It was a lot of fun putting this together with @halvorsenlab.bsky.social. Hope you check it out!

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WesleyWongLab @wesleywonglab.bsky.social · 15/01/2026

Our work on using DNA nanoswitches to characterize G-quadruplexes at the single-molecule level is now out in NAR!

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WesleyWongLab @wesleywonglab.bsky.social · 28/08/2025

Just published in ACS Central Science—our latest work using the Centrifuge Force Microscope to quantify immune-cell interactions. The new setup combines high-throughput force spectroscopy with multichannel fluorescence for single-cell studies. pubs.acs.org/doi/10.1021/...

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WesleyWongLab @wesleywonglab.bsky.social · 09/05/2025

New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025... We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech

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WesleyWongLab @wesleywonglab.bsky.social · 04/05/2025

Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at doi.org/10.1101/2025...

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