Students stopped a moving school bus after the driver suffered a medical emergency and passed out. What happened?
The driver has since been cleared to drive again. Why?
abcnews.com/GMA/Living/s...
VirusSucks.com
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#LongCovid since May 9, 2022. I was out for my morning run when exhaustion hit me. PEM, orthostatic intolerance, etc Last #SARSCov2 infection: April 2022. Medical news m.youtube.com/@VirusSucks-com/shorts #COVID is airborne so ventilate
![Then the other thing I sometimes see is that [individuals] will say they got the vaccine before, but then they ended up getting the flu. So, I have another prepared remark where we talk about that, saying yes, you can still get the flu, but the vaccine helps keep you out of the hospital. There's just a lot of not understanding what the vaccine's really supposed to do
https://www.pharmacytimes.com/view/expert-q-a-vaccine-hesitancy-remains-the-biggest-barrier-to-flu-vaccination](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:szc7xq5qv7wg2abye6tlvet2/bafkreihz73niar665vrgcnoayqvvwru7yvngkxrb6555lbml2sqvkcdv2y)
![11. Chronic Active Epstein–Barr Virus Disease (CAEBV)
Chronic active EBV disease (CAEBV) is a rare, potentially fatal lymphoproliferative syndrome affecting T and/or NK lymphocytes, reclassified by the WHO in 2022 as a proliferative entity in its own right rather than a simple persistent infection; it mainly affects children and young adults, with a rising incidence in adults, and predominates in East Asia and among Indigenous populations of Latin America, with a predisposing genetic background (HLA-DQB1 allele) suspected [10]. Pathophysiologically, the classic pediatric model describes an initial infection of bone marrow hematopoietic progenitors with establishment of type II latency (EBNA1, LMP1, LMP2) in T or NK lymphocytes, LMP1 activating the NF-κB and JAK/STAT pathways and promoting cell proliferation and immortalization; in adults, an alternative model suggests direct infection of mature T/NK lymphocytes carrying acquired genetic alterations, with viral strains harboring deletions that favor “leaky” expression of the lytic gene BZLF1, giving rise to genomic instability conducive to clonal expansion and tumor progression [10]. The clinical picture combines persistent or recurrent mononucleosis-like symptoms (fever, lymphadenopathy, hepatosplenomegaly) lasting more than 3 months, which may be complicated by severe visceral involvement (uveitis, central nervous system involvement, interstitial lung disease, myocarditis, coronary artery aneurysms), or may progress to HLH or T/NK-cell leukemic or lymphomatous transformation if left untreated. Diagnosis relies on four criteria—persistent symptoms beyond 3 months, high EBV viral load (>10,000 IU/mL), demonstration of EBV infection in T or NK lymphocytes (EBER-positive cells), and exclusion of a pre-existing immunodeficiency or lymphoma [10]. Conventional antivirals and chemotherapy or corticosteroid therapy alone provide only transient control; hematopoietic stem cell transplantation with reduced-intensity condition](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:szc7xq5qv7wg2abye6tlvet2/bafkreidzcf4jzwb7m2mrsrs4kdfbcvv4szjx45svl2cee625yizwpcv3ui)
![Vol. 18, No. 868
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Research Article
MULTIPLE SCLEROSIS
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The nucleoside analog kamuvudine-9 shows protective and therapeutic efficacy in a mouse model of multiple sclerosis
Praveen Yerramothu https://orcid.org/0000-0001-6635-6681, Kameshwari Ambati, [...] , and Jayakrishna Ambati https://orcid.org/0000-0003-1622-6365+36 authors Authors Info & Affiliations
Science Translational Medicine
23 Sep 2026
Vol 18, Issue 868
DOI: 10.1126/scitranslmed.aei2870
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Abstract
Innate immune signaling through inflammasome activation has been implicated in the pathogenesis of multiple sclerosis (MS). We previously demonstrated that nucleoside reverse transcriptase inhibitors (NRTIs), drugs approved to treat HIV and hepatitis B virus infections, and kamuvudines, safer NRTI derivatives, both inhibit inflammasome activation. Here, we report that in the experimental autoimmune encephalitis mouse model of MS, treatment with kamuvudine-9 (K-9), an NRTI derivative with an enhanced safety profile, prevented further neurological deficits and reversed preexisting paralysis and vision loss. K-9 promoted myelin and axonal preservation in the mouse spinal cord and abolished the increase in serum neurofilament light (NfL) chain. K-9 disrupted interactions between nucleotide-binding domain leucine-rich repeat (NLR) pyrin domain-containing protein 3 (NLRP3) and NIMA-related kinase 7 (NEK7) and between NLRP3 and NLR CARD domain containing 4 (NLRC4), inhibiting dual inflammasome activation. K-9 also exhibited appropriate safety and pharmacokinetic characteristics and biodistribution. In three distinct human cohorts, there was a lower incidence of MS in those individuals receiving NRTIs for HIV infection, preexposure prophylaxis for HIV, or hepatitis B virus infection. NRTI use was also associated with a reduction in relapse rate in individuals with MS. These findings provide a rationale for further investigating](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:szc7xq5qv7wg2abye6tlvet2/bafkreiaczc6wdt6jwetsga6huzyvjos2koadwthlnvs7673t7gsfc225fe)
![Military service
Allegiance
United States
Israel
Branch/service
United States Army
Israeli Defence Forces
Years of service
2000–2011
2015
Rank
Staff Sergeant
Volunteer
Unit
28th Ordnance Company[1] Logistics Corps
Battles/wars
War in Afghanistan
Operation Enduring Freedom
Awards
Bronze Star Medal[2][3]
Purple Heart
Defense Meritorious Service Medal
Army Commendation Medal (with valor)
A veteran of Operation Enduring Freedom, Mast lost both his legs while serving as a U.S. Army bomb disposal technician in Afghanistan in 2010. He received a Bronze Star and Purple Heart for his actions.
Mast was first elected to Congress in 2016. Since 2025, he has served as chair the House Foreign Affairs Committee.
Early life and education
edit
Mast was born and raised in Grand Rapids, Michigan.[4] He is the son of James Mast and Tixomena Trujillo. His maternal grandparents were immigrants from Mexico.[5] Mast graduated from South Christian High School in 1999.[6] In 2016, he obtained a Bachelor of Liberal Arts from the Harvard Extension School with a concentration in economics and minors in government and environmental studies](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:szc7xq5qv7wg2abye6tlvet2/bafkreic2pfgtpytoarwrl7tlzutkfc7ymtj36pj6mwdfycclddo7zs23sa)
