The decline in first-phase insulin response (FPIR) during the presymptomatic period of type 1 diabetes (T1D) is well established. In-situ functional studies with pancreas tissue slices showed that β-c...

The purpose of this phase of our engagement has not been to make or announce decisions. It has been to build a shared understanding of the pressures facing the system and to hear from applicants, reviewers and institutions on possible interventions and their implications.

p16INK4A is a cyclin-dependent kinase inhibitor that plays important roles in pancreatic islet beta-cell maturation, function, and senescence. As staining pattern consistency and reproducibility ha...

UM alum and researcher Samantha Pauls studies immune cells and their role in chronic inflammation.

Introduction Social deprivation is related to cardiovascular risk, but the prevalence of cardiometabolic risk factors by deprivation and sex is less explored. We addressed this in a large UK cohort.Me...

Obesity negatively impacts maternal and fetal metabolism, leading to the programming of metabolic disturbances in the offspring. We have previously re…

Lay Summary. Poor metabolic health and obesity during pregnancy are associated with a greater risk of childhood obesity and early development of metabolic

Gestational diabetes mellitus (GDM) represents one of the most consequential metabolic complications of pregnancy, affecting an estimated 14–17% of al…

Purpose of Review Maternal obesity is a major public health challenge that elevates pregnancy risks and predisposes offspring to lifelong metabolic disorders. Nutrition, as a modifiable determinant of...

Abstract. During the process of islet transplantation, islets undergo isolation and are then introduced into a new microenvironment where they need to adap

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AbstractPurpose. Exercise-mediated adaptations to mitochondria are well established in nongravid populations; however, the extent to which these adaptation

Abstract It has been well established that cardiovascular diseases exhibit significant differences between sexes in both preclinical models and humans. In addition, there is growing recognition that d...

Pancreatic islets maintain glucose homeostasis through coordinated action of endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding...

This study highlights the potential for using deep learning methods on longitudinal health data from both primary and secondary care to develop low-cost predictive tools for screening of young-onset t...

BackgroundMutations in the HNF1B gene can cause developmental and functional abnormalities in multiple organs such as the pancreas, kidneys, and liver. The p...

ObjectiveTo assess the adipogenic potential and mitochondrial bioenergetics of umbilical cord mesenchymal stem cells (UC-MSCs) derived from infants born to m...

A scientific detour reshaped how we treat diabetes and obesity Read More

Dr. Brandy Wicklow discusses a major study tackling Type 2 diabetes in First Nations children and improving care in Manitoba.

This study identifies GPR146 as a key regulator of fat–liver communication. In mice, reducing GPR146 in fat tissue lowers fat delivery to the liver and protects against obesity and fatty liver disease...

Elucidation of fundamental pancreatic-targeted mechanisms enables the development of lipid nanoparticles for the precise delivery of nucleic acid therapeutics to the pancreas, highlighting their promi...

Enriquez et al. describe a lipid nanoparticle platform for β cell-enriched mRNA delivery. The system delivers functional mRNA to mouse β cells and to human β cells in a xenotransplant model. In a mous...

Background Evidence on the individual risks of type 1 and type 2 diabetes following gestational diabetes mellitus (GDM) exposure, particularly in large Asian populations, remains limited. We examined ...