Why are some genes repeatedly lost during evolution while their paralogues are retained?
In our new preprint we address this by using the peptide-processing enzymes CPE and CPD in insects.
🧬 Functional genetics + evolutionary genomics + cross-species rescue
www.biorxiv.org/content/10.6...
biorxiv.org
Gene loss propensity for metallocarboxypeptidase E in insects is shaped by structural versatility and broader expression of metallocarboxypeptidase D but not functional importance
Gene loss is a widespread phenomenon that shapes genome evolution, yet the factors determining why certain genes are repeatedly lost while other functionally related genes are retained remain poorly u...