iiinova — where your digital self keeps evolving

Reposted by Vera Karlbauer

Max Planck Institute of Psychiatry @mpi-psychiatry.bsky.social · 29/09/2026

🥳 Congratulations to our director Peter Falkai for being awarded the prestigious Jean Delay Prize from the World Psychiatric Association! 🔗Read all about it: www.psych.mpg.de/2993203/worl... #psychiatry #schizophrenia #research #jeandelayprize #wpa26

psych.mpg.de

World-Class Research on Schizophrenia

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Reposted by Vera Karlbauer

Gareth Millward @millieqed.bsky.social · 15/05/2026

Academia relies on good faith. It cannot be done otherwise. This is precisely why plagiarists, people who fake data, people who deliberately ignore counter-evidence, and fascists need to be driven out. Full cordon sanitaire against this crap.

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Reposted by Vera Karlbauer

LMU Open Science Center @lmu-osc.bsky.social · 04/05/2026

🚀 The LMU Open Science Center’s (OSC) new website is live! We now have a refreshed online home, with all of our training programs, resources, initiatives, members, and partners’ profiles in one place. 🔗 Explore it here: bit.ly/4tb4RyM What you’ll find on the website: ⬇️

bit.ly

LMU Open Science Center

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Vera Karlbauer @vera-karlbauer.bsky.social · 01/05/2026

What does accelerated biological aging actually mean for children? Can we measure it with algorithms only trained in adults? And do different biomarkers of aging measure the same thing? Find out at my #SOBP2026 talk tomorrow afternoon 🧬🧠

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Reposted by Vera Karlbauer

Kira Höffler @kirahoeffler.bsky.social · 23/04/2026

Ahhh, I’m super excited to see this one out in the press!

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Reposted by Vera Karlbauer

LMU Open Science Center @lmu-osc.bsky.social · 14/02/2026

We ♥ Free Software! On Love Free Software Day, huge thanks to the maintainers of tools we rely on and teach about daily: OpenAlex, R, Quarto, Git, renv, Zotero, RDMO, formR.. Free software is collective infrastructure for open, reproducible research. Thank you! #OpenScience #FOSS #Reproducibility

Red card with pixelised text in hearts: use, study, share, improve.
I love Free Software
ilovefs.org

CC.BY-SA sticker design from the “I love Free Software” campaign of the Free Software Foundation Europe"

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

13/13 Huge thanks to everyone involved – especially the Kids2Health participants! This work is only possible because way more children than expected were brave enough to give blood samples! If you have questions about the data, or want to discuss implications of the results, please get in contact 🧬

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

12/13 We need more epigenetic measures for pediatric populations – ideally valid across tissues. You can use our epigenome-wide correlation database to train such measures, e.g. by only selecting CpGs with high cross-tissue generalizability. Download the data here: doi.org/10.5281/zeno...

doi.org

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

11/13 What can we conclude from this? An ideal epigenetic measure should correlate highly and perform equally (scenario 1) in blood and saliva. Only 1/22 measures met both criteria (most measures met just one). So, be cautious when applying epigenetic measures outside their training age and tissue!

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

10/13 What does this mean for previous EWAS results? We downloaded significant EWAS hits and calculated their average cross-tissue correlation based on our data. Many health-relevant traits (e.g. immune & metabolic) showed small correlations, implying high tissue-specificity of EWAS hits.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

9/13 Moving from aggregated measures to epigenome-wide analyses, we estimated within-person blood-saliva correlations for 815,069 CpGs. Correlations were low for most CpGs (mean rho=0.15). Only a small subset (2-3%) of CpGs was variable and highly correlated – maybe useful for training new measures.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

8/13 Next question: are previously reported effects of early-life adversity and SES consistent across tissues? Yes – effect directions were mostly the same in blood and saliva. We found a consistent signature of ELA/SES on elevated epigenetic CRP and lower epigenetic-g (trained on cognition).

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

7/13 Expanding previous work by Abner Apsley & @sepidehzarandooz.bsky.social, we examined within-person correlations of epigenetic measures between blood and saliva. 6/22 measures correlated strongly between tissues. Concerningly, age acceleration estimates were moderately correlated at best.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

6/13 Same for epigenetic scores: in scenario 1 (including 3 scores), epigenetic CRP was not associated with measured CRP in saliva, but behaved similarly to blood after cell type correction. In scenario 2, salivary DNAmTL did not correlate with measured telomere length no matter what.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

5/13 In scenario 1, associations of GrimAge2 and chronological age differed in blood and saliva, but these differences are attenuated with cell type correction. 6 clocks fall into scenario 1. In scenario 2, PedBE clearly performed better in saliva than blood regardless of cell type correction.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

4/13 We first checked: how are epigenetic and chronological age correlated, i.e. how well do epigenetic clocks perform, and does this differ between tissues? Results can be clustered into 2 scenarios.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

3/13 But can we generalize across age groups and tissues? We investigate this in the Kids2Health cohort, collected at #Charite Berlin. We calculated 22 common epigenetic measures in matching blood and saliva methylation (EPICv2) from 291 children aged 3-12, 56% exposed to early-life adversity.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

2/13 Epigenetic clocks and scores are investigated in children as biomarkers for health outcomes following early-life exposures. The problem is: most epigenetic measures are trained in adult blood, while saliva samples are more readily available in pediatric cohorts.

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Vera Karlbauer @vera-karlbauer.bsky.social · 17/12/2025

1/13 Can epigenetic clocks and scores trained in adult blood be applied to blood and saliva in children? We systematically explore this in our new pre-print in a cohort with 291 matched pediatric blood and saliva samples @binderlabmpip.bsky.social 🩸💧🧬🧒🧵 doi.org/10.64898/202...

doi.org

Limited Generalizability of Epigenetic Clocks and Scores Across Pediatric Tissues and Age Ranges

Epigenetic clocks and scores have been investigated as potential biomarkers of later-life health outcomes following early-life exposures. In pediatric settings, DNA methylation (DNAm) is often measure...

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Vera Karlbauer @vera-karlbauer.bsky.social · 12/10/2025

Heard about epigenetic aging at #ECNP2025 ? Curious to find out whether epigenetic clocks and scores also work in children? Want to know about consistent effects of childhood trauma across blood and saliva? Check out poster PS02-1267 today!

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Reposted by Vera Karlbauer

LMU Open Science Center @lmu-osc.bsky.social · 19/09/2025

We wrapped up our fourth day of the Open Science Summer School 2025 ✅ Although the public lectures are over, registered participants still have one more day to benefit from the workshops and interactive sessions! You can find slides and recording of the public lectures here: osf.io/x639j/files/...

Female facilitator Reema Gupta wearing a brown jersey and blue jeans stands as she helps a female participant sitting behind her grey laptop wearing glasses and a brown top. Visible on the table in front of them are a mug with coffee, an empty glass, green and pink Post-It notes, a computer mouse, and a microphone.

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Reposted by Vera Karlbauer

LMU Open Science Center @lmu-osc.bsky.social · 11/09/2025

💻 Make your research more reproducible by making your code more readable. Get recommendations and key strategies for clean code! Attend the “Readable code” lecture by @vera-karlbauer.bsky.social and Jonas Hagenberg on Thurs 18 Sept, 9:00-9:45. 👉 Register here: www.pretix.osc.lmu.de/lmu-osc/OSSS...

Promotional poster for the LMU Open Science Center Summer School 2025 Public Lecture. The poster features photos of speakers Vera Karlbauer and Jonas Hagenberg. The text states the lecture focuses on recommendations and strategies for readable code; time and date of lecture being 09:00-09:45 CEST on Thursday September 18 2025; and instructions to register online. Logos of LMU Open Science Center, LMU, and Universitätsbibliothek München are displayed at the bottom.

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Vera Karlbauer @vera-karlbauer.bsky.social · 12/09/2025

Super stoked to be a part of this!

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Reposted by Vera Karlbauer

Randall Munroe @xkcd.com · 25/04/2025

PhD Timeline xkcd.com/3081

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Reposted by Vera Karlbauer

Alicia Schowe @aliciaschowe.bsky.social · 26/04/2025

How did the COVID-19 pandemic affect epigenetic aging? Find out at poster S23! #SOBP2025

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Vera Karlbauer @vera-karlbauer.bsky.social · 26/04/2025

Do adult blood-trained epigenetic measures generalize to child saliva? What does this mean for psychiatric epigenetics? Come find out and talk to me at poster S193 - now with new cross-tissue epigenome-wide results! #SOBP2025

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Reposted by Vera Karlbauer

Kira Höffler @kirahoeffler.bsky.social · 25/04/2025

#SOBP2025 Stop by poster 206 if you're interested in epigenetic markers for psychotherapy response - or just want to chat.

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Reposted by Vera Karlbauer

Abdel Abdellaoui @dr-appie.bsky.social · 26/03/2025

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

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Vera Karlbauer @vera-karlbauer.bsky.social · 13/03/2025

Also stop by poster 50 and talk to Alicia Schowe about genetic and environmental contributions to salivary DNA methylation! #Epigenomics25

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Vera Karlbauer @vera-karlbauer.bsky.social · 13/03/2025

Curious about meQTLs, inflammation, and childhood adversity? Check out Darina Czamara‘s super cool results at poster 8! #Epigenomics25

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Vera Karlbauer @vera-karlbauer.bsky.social · 12/03/2025

Want to know more about cross-tissue correlations between epigenetic clocks and scores in child blood and saliva? Visit poster 29 at #Epigenomics25 to find out more! @eventswcs.bsky.social

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Vera Karlbauer @vera-karlbauer.bsky.social · 12/03/2025

The @binderlabmpip.bsky.social translational genomics team in the Eagle Pub in Cambridge where Watson & Crick announced in 1953 they (and Rosalind Franklin) had "discovered the secret of life". We are now looking forward to the #Epigenomics25 conference - see you there! @eventswcs.bsky.social

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