Really happy to see our work on Alzheimer’s disease (AD) microglia published in @science.org www.science.org/doi/10.1126/.... A great work at IBiS from Manuel Sanchez-Garcia, Nieves Lara-Ureña, Rosana March-Diaz, @alicielena.bsky.social , and all our collaborators.
science.org
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression
PHD3 inhibition slows down the pathology and behavioral decline of an Alzheimer’s disease mouse model.