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Vaibhav Mahajan

@vaibhavmahajan.bsky.social
327 followers 89 following 29 posts

Postdoc with Johanna Ivaska, Turku Bioscience | Ph.D. with Anna Taubenberger, TU Dresden | M.Res. with Buzz Baum, UCL | Interested in mechanics, 3D systems, evolution and all of cell biology

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Reposted by Vaibhav Mahajan
Ivaska Lab @ivaskalab.bsky.social · 16/07/2026
New paper alert! Michal Dibus and team show tensin-1 forms reversible condensates that act as reservoirs for adhesion proteins, tuning adhesion turnover and cell migration - a cool new role for phase separation in cell adhesion dynamics! Congratulations to the team 🎉! Paper here: bit.ly/4y9E8Xr
bit.ly
Adhesion-derived condensates control component availability to regulate adhesion dynamics - Nature Communications
Integrin adhesions allow dynamic cell-matrix interactions to regulate cell behaviour. Here, the authors reveal that tensin 1, a multidomain adaptor protein, forms condensates in cells that act as reve...
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Reposted by Vaibhav Mahajan
Michal Dibus @midibu.bsky.social · 10/07/2026
1/5 🎉 Finally, the results of my main postdoctoral project are out in @natcomms.nature.com! Adhesion-derived condensates control component availability to regulate adhesion dynamics bit.ly/4y9E8Xr Also excited to see the paper highlighted in Nat Comms Editors’ Highlights 🥳 bit.ly/44n4O9i
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Reposted by Vaibhav Mahajan
Markus Mukenhirn @markusmukenhirn.bsky.social · 24/03/2026
finally out @vaibhavmahajan.bsky.social! advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of can...
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Vaibhav Mahajan @vaibhavmahajan.bsky.social · 24/03/2026
I am happy to share that our paper is now available online at Advanced Science @wiley.com advanced.onlinelibrary.wiley.com/doi/epdf/10....
advanced.onlinelibrary.wiley.com
Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions
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Reposted by Vaibhav Mahajan
Mathilde Mathieu @mathildemathieu.bsky.social · 04/02/2026
I am very excited to share this preprint which has been my main postdoc project! We identified leupaxin as a negative regulator of durotaxis via paxillin-FAK inhibition in MDA-MB-231 brain and bone tropic metastatic variants. www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Vaibhav Mahajan
Vaibhav Mahajan @vaibhavmahajan.bsky.social · 05/10/2025
How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv! www.biorxiv.org/content/10.1... See the thread 🧵 below for more information.
biorxiv.org
Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells can dynamic...
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Vaibhav Mahajan @vaibhavmahajan.bsky.social · 05/10/2025
How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv! www.biorxiv.org/content/10.1... See the thread 🧵 below for more information.
biorxiv.org
Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells can dynamic...
3157
Reposted by Vaibhav Mahajan
Fischer-Friedrich Lab @fischerfriedriclab.bsky.social · 27/03/2025
It’s the #filopodia, stupid! 🚀 We just released our new study uncovering how filopodia and hydrostatic #pressure contribute to the regulation of #membrane #tension. 👉 Check it out on bioRxiv: biorxiv.org/content/10.1... #cellbiology #biophysics #actin #mechanobiology
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Reposted by Vaibhav Mahajan
Vaibhav Mahajan @vaibhavmahajan.bsky.social · 11/01/2025
Want to get started with analysing your cells/spheroids/organoids in 3D matrices? Check out our review about imaging, biomechanical and biochemical phenotyping in 3D @cp-trendscellbio.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Phenotypic analysis of complex bioengineered 3D models
With advances in underlying technologies such as complex multicellular systems, synthetic materials, and bioengineering techniques, we can now generat…
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Vaibhav Mahajan @vaibhavmahajan.bsky.social · 11/01/2025
Want to get started with analysing your cells/spheroids/organoids in 3D matrices? Check out our review about imaging, biomechanical and biochemical phenotyping in 3D @cp-trendscellbio.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Phenotypic analysis of complex bioengineered 3D models
With advances in underlying technologies such as complex multicellular systems, synthetic materials, and bioengineering techniques, we can now generat…
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Reposted by Vaibhav Mahajan
Helen Matthews @helenkmatthews.bsky.social · 26/11/2024
🚨THREE fully-funded PhD positions available! 2 in our lab @mcb-sheffield.bsky.social and 1 with our collaborators in Leeds. Three exciting but very different projects in cancer cell biology, biophysics & chemical/structural biology. 👇 full details in 🧵
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