Tetherin is a restriction factor that inhibits budding of enveloped viruses, resulting in an accumulation of virions on the cell surface. Snow et al. show that HIV-1 Vpu counteracts this restriction b...

Tetherin is a restriction factor that inhibits budding of enveloped viruses, resulting in an accumulation of virions on the cell surface. Snow et al. show that HIV-1 Vpu counteracts this restriction b...

The Wisconsin National Primate Research Center is proud to share that Dr. Toni Ziegler will be honored with the Midwest Primate Interest Group (MPIG) Distinguished Primatologist Award at the 23rd Annu...

Infant macaques showed immune changes and signs of faster aging years after inhaling smoke

The human brain must support both stable and flexible neural dynamics to adapt to changing contexts. The thalamus has been hypothesized to coordinate these opposing dynamical regimes in the cerebral c...

The human brain must support both stable and flexible neural dynamics to adapt to changing contexts. The thalamus has been hypothesized to coordinate these opposing dynamical regimes in the cerebral c...

Author summary Zika virus (ZIKV) infection during pregnancy is associated with pregnancy loss, severe birth defects, including microcephaly and developmental delays, and other subtle neurologic change...

Author summary Zika virus (ZIKV) infection during pregnancy is associated with pregnancy loss, severe birth defects, including microcephaly and developmental delays, and other subtle neurologic change...

By Bekah McBride When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling th...

An outbreak of Shigella in nonhuman primates enabled discovery of more than 100 protective and pathogenic antibodies against key vaccine antigens.

An outbreak of Shigella in nonhuman primates enabled discovery of more than 100 protective and pathogenic antibodies against key vaccine antigens.

When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling the immune response...

New Concern for Newborns Researchers from the University of Wisconsin–Madison, in collaboration with the National Primate Research Center (NPRC), found that Zika exposure during pregnancy may cause de...

When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling the immune response...

By Bekah McBride When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling th...

New Concern for Newborns Researchers from the University of Wisconsin–Madison, in collaboration with the National Primate Research Center (NPRC), found that Zika exposure during pregnancy may cause de...

At the Wisconsin National Primate Research Center, we have identified a family of rhesus carrying the microtubule-associated protein tau (MAPT) R406W mutatio...

At the Wisconsin National Primate Research Center, we have identified a family of rhesus carrying the microtubule-associated protein tau (MAPT) R406W mutatio...

Our geometric intuition, long considered something that sets us apart, seems to be shared with other primates.

“Likweli” find highlights importance of conservation work, researchers say

While rare, a subset of PLWH, termed post-treatment controllers (PTCs), maintains viral control following antiretroviral treatment (ART) interruption. However, little is known about whether this control reflects a complete absence of viral replication or continual, subclinical replication. Here, we address a key knowledge gap regarding how viral populations change during CD8ɑ+ cell-mediated PTC of SIV. We utilized our Mauritian cynomolgus macaque model of HIV infection, in combination with barcoded SIVmac239M and deep sequencing, to characterize viral lineages and MHC-I-restricted CD8+ T-cell epitopes throughout the study. Our findings demonstrate that early ART initiation limits viral diversity, that pre-ART replication predicts post-ART reactivation, and that CD8ɑ+ cells can suppress viral replication without the emergence of mutations within CD8+ T-cell epitopes. These insights establish MCMs as a valuable model for dissecting mechanisms of durable ART-free viral control and highlight the potential of CD8-mediated immune control as a therapeutic target for HIV cure strategies.

Cell-based therapies have transformed the treatment landscape for cancer, yet their clinical translation remains limited by unpredictable in vivo behavior and variable patient responses. Accurate, non...

While rare, a subset of PLWH, termed post-treatment controllers (PTCs), maintains viral control following antiretroviral treatment (ART) interruption. However, little is known about whether this control reflects a complete absence of viral replication or continual, subclinical replication. Here, we address a key knowledge gap regarding how viral populations change during CD8ɑ+ cell-mediated PTC of SIV. We utilized our Mauritian cynomolgus macaque model of HIV infection, in combination with barcoded SIVmac239M and deep sequencing, to characterize viral lineages and MHC-I-restricted CD8+ T-cell epitopes throughout the study. Our findings demonstrate that early ART initiation limits viral diversity, that pre-ART replication predicts post-ART reactivation, and that CD8ɑ+ cells can suppress viral replication without the emergence of mutations within CD8+ T-cell epitopes. These insights establish MCMs as a valuable model for dissecting mechanisms of durable ART-free viral control and highlight the potential of CD8-mediated immune control as a therapeutic target for HIV cure strategies.

A new investigational treatment for Parkinson’s disease is showing early promise in its first human clinical trial, thanks in part to foundational work at the University of Wisconsin–Madison and the W...

Congenital heart defects are the most common type of birth defect in the United States and can result in heart failure early in life. Stem cell grafts offer potential as a treatment for cardiac defect...

Congenital heart defects are the most common type of birth defect in the United States and can result in heart failure early in life. Stem cell grafts offer potential as a treatment for cardiac defect...

“Innovations like xenotransplantation would never have reached clinical trials without animal experimentation,” writes transplant surgeon Joshua Mezrich.

A new investigational treatment for Parkinson’s disease is showing early promise in its first human clinical trial, thanks in part to foundational work at the University of Wisconsin–Madison and the W...

Smith and colleagues report that SIRPA knockout iPSC-derived macrophages possess enhanced antitumor activity against various CD47-expressing tumors when combined with cancer-targeted monoclonal antibo...

The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell surface protein that regulates leukocyte adhesion, migration, and acti…