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Uli Klümper

@ulikluemper.bsky.social
961 followers 1.9K following 149 posts

Microbial Ecologist @ TU Dresden Focusing on Evolution, Ecology and Environmental dimensions of AMR & plasmids Formerly @ DTU & UoExeter He/him

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Uli Klümper @ulikluemper.bsky.social · 02/10/2026
🤖🦠 New paper in ES&T! “Predicting Chemical Stressor Effects on Conjugative Plasmid Transfer Rates Using Machine Learning” Led by Ana Rey-Sogo. We asked... Can chemical structure help predict effects on plasmid transfer and AMR spread? Turns out it can! 🧬 doi.org/10.1021/acs....
doi.org
Predicting Chemical Stressor Effects on Conjugative Plasmid Transfer Rates Using Machine Learning
Abstract. Chemical stressors in environmental and clinical settings can alter conjugative plasmid transfer, which is a key process driving antibiotic resis
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Uli Klümper @ulikluemper.bsky.social · 07/08/2026
📢 Our new @biorxivpreprint.bsky.social: Microbial community diversity predicts invasion resistance of freshwater biofilms against antibiotic-resistant bacteria. Read it here: doi.org/10.64898/202... #AMR #MicrobialEcology #Antiversa #Biodiversa+
doi.org
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Uli Klümper @ulikluemper.bsky.social · 16/07/2026
🌱 New paper in ES&T led by Y. Su & Ping Han! Nitrification Couples Microbial CO₂ Fixation to Warming and Drought Responses in Alpine Grassland Soils We show that nitrification is linked to CO₂ fixation, with AOA emerging as key players under warming and drought 📄 doi.org/10.1021/acs....
doi.org
Nitrification Couples Microbial CO2 Fixation to Warming and Drought Responses in Alpine Grassland Soils
Microbial CO2 fixation in alpine grassland soils is highly sensitive to warming and drought. Nitrogen inputs from grazing may stimulate autotrophic nitrifiers, including ammonia-oxidizing archaea (AOA...
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Uli Klümper @ulikluemper.bsky.social · 14/07/2026
🧬 New @biorxivpreprint.bsky.social led by my PhD student Eda Deniz Erdem! Resistance to the conjugation inhibitor AZT reshapes metabolic compatibility between mating partners during plasmid transfer 📄 doi.org/10.64898/202...
doi.org
Resistance to the conjugation inhibitor AZT reveals mating partner incompatibility during plasmid transfer
Plasmid-mediated dissemination of antibiotic resistance genes (ARGs) is a major driver of antimicrobial resistance (AMR). The nucleoside analogue zidovudine (azidothymidine, AZT) has emerged as a prom...
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Uli Klümper @ulikluemper.bsky.social · 14/07/2026
🧬 New @biorxivpreprint.bsky.social led by my PhD student Diala Konyali! Cycles of contamination and recovery: Combined sewer overflows drive acute but transient antimicrobial resistance exposure in an urban stream 📄 doi.org/10.64898/202...
doi.org
Cycles of contamination and recovery: Combined sewer overflows drive acute but transient antimicrobial resistance exposure in an urban stream
Combined sewer overflows (CSOs) are a major pathway for untreated wastewater into urban streams, yet their role in shaping antimicrobial resistance (AMR) dynamics remains poorly understood. Here, we u...
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Uli Klümper @ulikluemper.bsky.social · 13/05/2026
Our new advanced wastewater treatment paper in npj Clean Water: Reusable immobilised quaternary ammonium particles reduce microbial and resistome burdens without promoting resistance selection during wastewater post-treatment www.nature.com/articles/s41...
nature.com
Reusable immobilised quaternary ammonium particles reduce microbial and resistome burdens without promoting resistance selection during wastewater post-treatment - npj Clean Water
npj Clean Water - Reusable immobilised quaternary ammonium particles reduce microbial and resistome burdens without promoting resistance selection during wastewater post-treatment
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Uli Klümper @ulikluemper.bsky.social · 02/05/2026
🌍 Why it matters: EV cargo is not random but structured by plasmid interactions, determining which genes enter the extracellular pool In multi-plasmid systems, this could directly influence AMR dissemination Would love to hear your thoughts 👇 #Plasmids #HGT #EVs #AMR 6/6
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Uli Klümper @ulikluemper.bsky.social · 02/05/2026
⚙️ Mechanistically: Mobilizable plasmids exploit conjugative transfer machinery, gain access to membrane-associated export sites, and outcompete conjugative plasmids for EV incorporation. 👉 The same interaction principle extends beyond conjugation. 5/6
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Uli Klümper @ulikluemper.bsky.social · 02/05/2026
🔬 Results: When alone → conjugative plasmids dominate EV cargo When coexisting → mobilizable plasmids take over This leads to a complete reversal of plasmid ratios and strong fold-changes in EV incorporation. 4/6
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Uli Klümper @ulikluemper.bsky.social · 02/05/2026
This work, driven by Faina Tskhay with Haining Huang (UFZ) and Anja Worrich (BTU), asked: 👉 Do plasmid–plasmid interactions shape EV-mediated gene export? 3/6
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Uli Klümper @ulikluemper.bsky.social · 02/05/2026
In conjugation, mobilizable plasmids exploit conjugative machinery, compete for access, and reshape transfer dynamics. Outside of conjugation, these interactions were largely assumed to not matter for HGT. We tested this for extracellular vesicles (EVs). 2/6
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Uli Klümper @ulikluemper.bsky.social · 02/05/2026
🚀New preprint by my PhD Student Faina Tskhay Plasmid-plasmid interactions reshape extracellular vesicle cargo and gene transfer potential 👉https://doi.org/10.64898/2026.04.28.721519 Plasmid interactions are well known in conjugation, but are they relevant for other gene transfer routes? #AMR 1/6
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Uli Klümper @ulikluemper.bsky.social · 27/03/2026
Co-authors: @ulikluemper.bsky.social, Ana Alexandra Pereira, Luís Melo, Thomas Berendonk. Great collaboration between University of Porto, @tudresden.bsky.social Institute of Hydrobiology as part of the #JPIAMR PRESAGE project. 5/5
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Uli Klümper @ulikluemper.bsky.social · 27/03/2026
Importantly, this approach: 🦠Works in real WW systems 🦠Does not enrich pathogens 🦠Suppresses plasmid transfer 🦠Remains effective upon reuse Overall, it points toward a new, evolution-conscious framework for WW polishing, decoupling antimicrobial efficacy from AMR risk. 4/5
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Uli Klümper @ulikluemper.bsky.social · 27/03/2026
💡Main storyline: We show that immobilising quaternary ammonium compounds onto particles creates a contact-restricted disinfection strategy that achieves strong microbial and ARG reduction (~5.5 log), while avoiding #AMR selection, co-selection, and #HGT. 3/5
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Uli Klümper @ulikluemper.bsky.social · 27/03/2026
Led by Marta Redondo and Alan Elena, this study tackles a key challenge in AMR mitigation: how to effectively disinfect wastewater without unintentionally selecting for resistance. biorxiv.org/content/10.6... 2/5
biorxiv.org
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Uli Klümper @ulikluemper.bsky.social · 27/03/2026
🌊🦠Our latest work on water treatment now available as a @biorxivpreprint 🌊🦠 “Reusable immobilised quaternary ammonium particles reduce microbial and resistome burdens without promoting #AMR selection during wastewater post-treatment” 🔗 biorxiv.org/content/10.6... 1/5
biorxiv.org
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Uli Klümper @ulikluemper.bsky.social · 17/03/2026
Important implications for #OneHealth, WW management, and AMR risk assessment. Great collaboration between Institute of Hydrobiology at @tudresden.bsky.social & Institute of Biological Research, Cluj-Napoca as part of the @biodiversa.eu ANTIVERSA project. Exciting to see this out! 5/5
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Uli Klümper @ulikluemper.bsky.social · 17/03/2026
👉 Take-home: where and how wastewater is released matters. Low-flow environments may help reduce ARG persistence, while flowing systems can sustain and spread resistance. 4/5
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Uli Klümper @ulikluemper.bsky.social · 17/03/2026
🔑Key findings: -Flow maintains ARGs, while static systems show consistent decline -Dynamic systems support higher diversity -Hydrodynamics can outweigh the effect of wastewater input alone -ARG persistence is strongly shaped by physical conditions, not just contamination 3/5
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Uli Klümper @ulikluemper.bsky.social · 17/03/2026
Using controlled flume experiments, we compared static (lake-like) vs dynamic (river-like) conditions and tracked ARGs, MGEs, and microbial communities over time. link.springer.com/article/10.1... 2/5
link.springer.com
Hydrodynamics Shape Antibiotic Resistance in Wastewater-Impacted River Biofilms - Microbial Ecology
Microbial Ecology - Antimicrobial resistance (AMR) is a critical threat to global health, with aquatic ecosystems playing a key role in the spread of antibiotic resistance genes (ARGs), especially...
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Uli Klümper @ulikluemper.bsky.social · 17/03/2026
Our new ANTIVERSA (@biodiversa.eu) study explores how water flow controls #AMR Hydrodynamics shape antibiotic resistance in wastewater-impacted river biofilms 👩‍🔬A. Teban-Man, E.D. Erdem, T. Berendonk, U. Klümper, C. Coman & E. Szekeres link.springer.com/article/10.1... (in Microbial Ecology) 1/5
doi.org
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Uli Klümper @ulikluemper.bsky.social · 13/03/2026
Interesting twist: 🦠This barrier effect mainly acts at the outer boundary of mature biofilms 🦠When donor & recipient cells grow in co-established biofilms, plasmid transfer remains high Take-home: 🦠Biofilm structure and hydration strongly shape horizontal gene transfer 4/4
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Uli Klümper @ulikluemper.bsky.social · 13/03/2026
Key result: 🧫Biofilm EPS can act as a barrier to plasmid invasion. 🧫When water availability decreases, bacteria produce more EPS, which reduces plasmid transfer into biofilms. 🧫EPS-overproducing mutants showed the strongest suppression of plasmid invasion. 3/4
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Uli Klümper @ulikluemper.bsky.social · 13/03/2026
“Effect of biofilm lifestyle caused by water matric potential on invasion of exogenous plasmid.” doi.org/10.1093/isme... Thanks to Yijun Wang leading this study, with Arnaud Dechesne, Stéphanie Linnea Franck, Gang Wang and Barth F. Smets (@metlabau.bsky.social) as co-authors. 2/4
doi.org
Effect of biofilm lifestyle caused by water matric potential on invasion of exogenous plasmid
Abstract. Conjugal plasmid transfer is an efficient mechanism for gene exchange among bacteria. Most bacteria exist in biofilms encased in extracellular po
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Uli Klümper @ulikluemper.bsky.social · 13/03/2026
🥂 More than 10 years after completing my PhD, the final bit of unpublished work from that time has now contributed to a new paper published in @ISMEComms . Happy to finally conclude the PhD part of my scientific journey 🥂 doi.org/10.1093/isme... Read more below 🔽🔽🔽 1/4
doi.org
Effect of biofilm lifestyle caused by water matric potential on invasion of exogenous plasmid
Abstract. Conjugal plasmid transfer is an efficient mechanism for gene exchange among bacteria. Most bacteria exist in biofilms encased in extracellular po
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Uli Klümper @ulikluemper.bsky.social · 13/03/2026
New paper in Environmental Science & Technology 🧪 “Antibiotics or Heavy Metals in Livestock Wastewater: Which One Is the Main Driver for the Development and Spread of Antibiotic Resistance under Coexposure?” Led by Jin Huang and Bing Li. pubs.acs.org/doi/full/10....
pubs.acs.org
Antibiotics or Heavy Metals in Livestock Wastewater: Which One Is the Main Driver for the Development and Spread of Antibiotic Resistance under Coexposure?
Antibiotics and heavy metals are widely used in livestock farming to promote animal health and growth, leading to their frequent co-occurrence as contaminants in livestock wastewater. However, their r...
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Uli Klümper @ulikluemper.bsky.social · 10/02/2026
• ARGs were increasingly associated with mobilizable plasmids, integrons, and composite transposons, indicating elevated HGT potential. • Microbial community restructuring under antibiotic stress was marked by Enterococcus dominance and resistome host shifts.
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Uli Klümper @ulikluemper.bsky.social · 10/02/2026
Key findings: • Sulfonamide exposure selectively enriched sulfonamide resistance genes without broad co-selection of other ARG classes. • Distinct temporal dynamics: short-term stress amplified sul2/sul3, whereas long-term exposure favored sul1.
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Uli Klümper @ulikluemper.bsky.social · 10/02/2026
🐷 💊 Happy to share our latest paper in Journal of Hazardous Materials 🐷 💊 “Impact of sulfonamides on microbial community and antibiotic resistome profiles in anaerobic digestion of swine wastewater.” doi.org/10.1016/j.jh... led by Qinmao 'Brook' Zhou and Bing Li #AMR #microsky
doi.org
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Uli Klümper @ulikluemper.bsky.social · 03/02/2026
📄 New paper out in Water Research: Impact of human activities on groundwater biogeochemical cycles and microbial communities: Insights from metagenomic analysis Led by @pennyhan.bsky.social & Zhengxing Chen 🔗 doi.org/10.1016/j.wa...
sciencedirect.com
Impact of human activities on groundwater biogeochemical cycles and microbial communities: Insights from metagenomic analysis
Anthropogenic nitrogen pollution poses a systemic threat to microbial interaction networks and biogeochemical cycling in groundwater ecosystems, yet t…
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Reposted by Uli Klümper
jonkampouris.bsky.social @jonkampouris.bsky.social · 30/01/2026
Before leaving Dresden to increase my knowledge and independence as a researcher, I participated in a large-scale sampling campaign for the EMBARK project... some years later, this new and amazing study (which included these samples as well) came out!!!!!
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Uli Klümper @ulikluemper.bsky.social · 30/01/2026
Part of the JPIAMR SEARCHER project (antimicrobialresistance.eu) funded in Germany by the @BMFTR_bund
antimicrobialresistance.eu
SEARCHER – Surveillance for Emerging Antimicrobial Resistance through Characterization of the uncharted Environmental Resistome
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Uli Klümper @ulikluemper.bsky.social · 30/01/2026
Why this matters: Environmental resistomes are not just background noise. They contain functionally active genes with future clinical relevance. This work shows why functional discovery approaches are essential if AMR surveillance is to be proactive rather than reactive. 5/5
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Uli Klümper @ulikluemper.bsky.social · 30/01/2026
A personal highlight🍻: 3 of the newly identified resistance genes originated from a sampling campaign by Ioannis Kampouris and myself in Dresden, a nice reminder that my rare hands-on field sampling at human–environment interfaces can directly inform global #AMR risk assessment. 4/5
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Uli Klümper @ulikluemper.bsky.social · 30/01/2026
One gene (blaVEB-3) is mobile and already widespread in wastewater across multiple countries & several genes have closest homologs in known pathogens, highlighting realistic pathways by which environmental ARGs could mobilize into clinical bacteria in the future 3/5
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Uli Klümper @ulikluemper.bsky.social · 30/01/2026
Using functional metagenomics on environmental samples, we identified 4 yet unrecognized ARGs increasing cefiderocol MICs to clinically relevant levels. These include novel class A & D beta-lactamases (VEB-3, OXA-372-like, YbxI-like) & a truncated penicillin-binding protein 2/5
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Uli Klümper @ulikluemper.bsky.social · 30/01/2026
🧬 Our new paper in @ISMEJournal "Cefiderocol resistance genes identified in environmental samples using functional metagenomics" Led by Remi Gschwind and Etienne Ruppe as part of JPIAMR SEARCHER. academic.oup.com/ismej/advanc... #AMR #microsky 1/5
academic.oup.com
Cefiderocol resistance genes identified in environmental samples using functional metagenomics
Abstract. Antibiotic resistance poses a global public health threat, which can originate from the transfer of environmental antibiotic resistance genes to
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Uli Klümper @ulikluemper.bsky.social · 12/01/2026
New paper accepted in Microbiome 🎉 Weiss A, Elena AX, Klümper U, Dumack K We show that viruses and microeukaryotes strongly shape bacterial and ARG diversity in wastewater, highlighting the role of multi-trophic ecology. doi.org/10.1186/s401... #AMR #Microbiome #Wastewater #MicrobialEcology
doi.org
Client Challenge
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Uli Klümper @ulikluemper.bsky.social · 16/12/2025
👥 expertedly led by Jin Huang & Bing Li (Tsinghua University) with Jingjia Zhang, @ulikluemper.bsky.social, @jianhuaguo.bsky.social, Thomas Berendonk, Ryo Honda, Hebin Liang, Lin Lin, & Xiaoyan Li www.sciencedirect.com/science/arti... 3/3
sciencedirect.com
Combined exposure of enrofloxacin and disinfection byproducts under environmentally relevant concentrations enhances antibiotic resistance risks in livestock wastewater
Livestock wastewater is a crucial source of antibiotic resistance. However, the impact of disinfection byproducts (DBPs), stemming from disinfectants …
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Uli Klümper @ulikluemper.bsky.social · 16/12/2025
In this study, we show that environmentally relevant co-exposure to antibiotics and disinfection byproducts can substantially enhance antibiotic resistance risks at the microbial community level, with important implications for livestock wastewater management and #OneHealth risk assessment. 2/3
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Uli Klümper @ulikluemper.bsky.social · 16/12/2025
💊 🌊 🐷 Our new paper in Water Research💊 🌊 🐷 Combined exposure of enrofloxacin and disinfection byproducts under environmentally relevant concentrations enhances antibiotic resistance risks in livestock wastewater www.sciencedirect.com/science/arti... 1/3 #AMR #microsky
sciencedirect.com
Combined exposure of enrofloxacin and disinfection byproducts under environmentally relevant concentrations enhances antibiotic resistance risks in livestock wastewater
Livestock wastewater is a crucial source of antibiotic resistance. However, the impact of disinfection byproducts (DBPs), stemming from disinfectants …
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Uli Klümper @ulikluemper.bsky.social · 23/11/2025
I’m grateful that our group could contribute German wastewater samples to this truly collaborative dataset of 1240 sewage metagenomes from 111 countries. The study provides one of the most comprehensive comparisons between acquired ARGs and latent ones identified through functional metagenomics.
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Uli Klümper @ulikluemper.bsky.social · 23/11/2025
📢 New paper in @natcomms.nature.com Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes doi.org/10.1038/s414... Thrilled to share this massive global effort led by H.M. Martiny, @patrickmunk.bsky.social, F. Aarestrup & the Global Sewage Consortium
doi.org
Geographics and bacterial networks differently shape the acquired and latent global sewage resistomes - Nature Communications
Antimicrobial resistance genes that have been mobilized between bacterial species represent a subset of the naturally occurring resistome. Here, the authors compare the abundance, diversity and geogra...
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Uli Klümper @ulikluemper.bsky.social · 19/10/2025
Having a great time at the 6th Meeting of Bergey’s Society for Microbial Systematics #BISMiS in Qingdao, China. Thanks to the organizers for inviting me to give a talk on how we can infer pathogenicity and #AMR in environmental microbial communities based on their taxonomic makeup.
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Uli Klümper @ulikluemper.bsky.social · 29/09/2025
Our first manuscript from the TARGIM project led by Masoud Haghshenasfard: CFD and OCT-Based Optimisation of Impeller-Induced Shear Stress on Membrane Surfaces in a Circular Test Cell www.sciencedirect.com/science/arti...
sciencedirect.com
CFD and OCT-Based Optimisation of Impeller-Induced Shear Stress on Membrane Surfaces in a Circular Test Cell
This study investigates the distribution of shear stress in a lab-scale membrane bioreactor consisting of a 56 mm-diameter cylindrical test cell, a 0.…
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Uli Klümper @ulikluemper.bsky.social · 21/09/2025
In-person participation for the workshop (free of charge) is limited to 40 places and will be allocated on a first-come, first-served basis. To register, send an email to uli.kluemper@tu-dresden.de indicating your interest in attending. 3/3
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Uli Klümper @ulikluemper.bsky.social · 21/09/2025
As part of our new EU Project “One Bridge”, led by the University of Patras, we are organizing an 'AMR & #OneHealth Workshop in Dresden, Germany on the 6th of October 2025. The workshop will take place at BUSINESSPARK DRESDEN, Bertolt-Brecht-Allee 22-24, 01309 Dresden from 8:30 – 17:00. 2/3
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Uli Klümper @ulikluemper.bsky.social · 21/09/2025
🚨WORKSHOP announcement 🚨 “Making environmental #AMR Surveillance Fit for Purpose: Data Integration and the Ecology of Resistance” 6th of October Dresden, Germany Free of charge one-bridge.iwaterfood.gr/workshops/wo... Register now! Details below: 1/3
one-bridge.iwaterfood.gr
ONE-Bridge project | Conference | Workshops
Fostering collaboration and addressing the interconnected challenges at the interface of human, animal, and environmental health.
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Uli Klümper @ulikluemper.bsky.social · 21/09/2025
Our findings urge a #OneHealth rethink of antibiotic use in aquaculture. Check the full study led by Jin Huang (Central South University) & Bing Li (Tsinghua Uni Shenzhen Graduate School) here: www.nature.com/articles/s44...
nature.com
Microbial risks triggered by oral administration of antibiotics in fish aquaculture persist long after the legally mandated antibiotic withdrawal time - Nature Water
Florfenicol treatment substantially increased the abundance and mobility of antibiotic resistance genes (ARGs) in the common carp gut microbiome. The resistome and mobilome profiles failed to return t...
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