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Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry. DG harbors a long, complex glycan called matriglycan. Loss of matriglycan or reduction in its length disrupts DG function, causing ...

Molecular Psychiatry - Nonsense-mediated decay influences position-dependent effects of SCN2A premature stop codons on neuronal excitability and behavior

Abstract. The biological conservation between fungi and mammals due to a common ancestor has made development of selective antifungal drugs a difficult cha

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Background Migraine is a disorder of severe, recurrent headaches and debilitating sensory, cognitive and affective symptoms, often triggered by stress. Early life stress in childhood has been shown to...

Dystroglycanopathies are muscular dystrophies with varying clinical severities, ranging from congenital-onset to adult limb-girdle muscular dystrophy. Dystroglycanopathies are caused by a loss of func...

The past 5 years of success with calcitonin gene-related peptide (CGRP) based drugs has transformed migraine into a relatively treatable neurological disorder. There are now eight monoclonal antibo...

One of the classic techniques to allow detection of direct DNA-binding by sequence-specific transcription factors is the electrophoretic mobility shift assay (EMSA). EMSA takes advantage of the reduce...

Phosphodiesterase 5 (PDE5) plays critical role in the nitric oxide-cGMP signaling pathway. Consequently, PDE5 catalytic site inhibitors are widely use…

Aspergillus fumigatus is the major human filamentous fungal pathogen. While its importance as a pathogen is well-appreciated, our understanding of its biology is still at an early stage. One valuable ...

Fungal TOK potassium channels regulate ionic balance but remain poorly understood. Here, authors report the structure of TOK1 from Candida albicans, revealing a distinct architecture with a domain res...

Former endocrinology division chief and founder of the Carver College of Medicine Distinguished Mentor Award leaves lasting impact on diabetes research, education, and clinical care

BACKGROUND: NaV (voltage-gated sodium) channels drive cardiac excitability. Although NaV1.5 is the primary cardiac isoform, the composition and functional contributions of non-NaV1.5 isoforms in the h...

Hepatic de novo lipogenesis (DNL) is a fundamental process that supports energy storage, membrane biogenesis, and lipid signaling. However, chronicall…

Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in …

Over four decades, Kevin P. Campbell has led research on the mechanisms of muscle cell biology — with the goal of developing new treatment strategies

Migraine is a disabling neurovascular disorder with limited therapeutic options, especially for patients unresponsive to current treatments targeting …

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Ubiquitin chains direct post-ER membrane proteins toward different degradation routes. Here, the authors show that K63 chains promote lysosomal sorting, whereas K48 chains trigger “CUTUP”, a protein s...

Abstract. Aspergillosis caused by Aspergillus fumigatus is a clinical issue of such severity that the World Health Organization has designated this organis