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Market Shaping Accelerator (MSA)

@uchi-msa.bsky.social
76 followers 65 following 96 posts

The Market Shaping Accelerator aims to catalyze market shaping tools to accelerate innovation to solve the world’s most pressing challenges. marketshapingaccelerator.org

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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 05/10/2026
Congratulations to Michael Kremer, who is beginning his new role as World Bank Chief Economist! Michael helped shape @uchi-msa.bsky.social’s founding vision and advance the use of pull mechanisms to spur innovation. We’re grateful for his leadership and wish him every success.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/09/2026
Last week, the entire MSA Team Week came together in DC to make headway on #marketshaping. The retreat helped us (1) get closer to launching our current pull mechanisms and (2) consider new areas for work. The future of market shaping is bright! More ➡️ marketshapingaccelerator.org
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 10/09/2026
www.devex.com/news/how-a-n...
devex.com
How a new philanthropy model moved $533 million
Renaissance Philanthropy has mobilized half a billion dollars in under three years through a lean, time-bound fund model. Here is how it works and what it means for organizations operating in its issu...
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Reposted by Market Shaping Accelerator (MSA)
Center for Global Development @cgdev.org · 09/09/2026
How can philanthropy fund breakthroughs where markets fall short? @devex.com highlights NeoTest, a $60M pull-funding proposal from CGD’s @uchi-msa.bsky.social to accelerate neonatal sepsis diagnostics. www.devex.com/news/how-a-n...
devex.com
How a new philanthropy model moved $533 million
Renaissance Philanthropy has mobilized half a billion dollars in under three years through a lean, time-bound fund model. Here is how it works and what it means for organizations operating in its issu...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 09/09/2026
Philanthropy can help channel funds toward breakthroughs that markets aren't delivering. @devex.com highlights NeoTest, our proposed $60M pull-funding facility for neonatal sepsis diagnostics, as a ready-to-fund solution that could catalyze innovation. www.cgdev.org/blog/neotest...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/08/2026
📣 #WereHiring for a DC-based Research Assistant! Join us to work alongside leading researchers and policymakers on market-shaping proposals addressing global health, climate change, pandemic preparedness & more. 📅 Apply by October 15 centerforglobaldevelopment.applytojob.com/apply/gS6SSb...
centerforglobaldevelopment.applytojob.com
Research Assistant – Market Shaping Accelerator - Center for Global Development - Career Page
Apply to Research Assistant – Market Shaping Accelerator at Center for Global Development in Washington, DC.
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Center for Global Development @cgdev.org · 24/08/2026
📣 #WereHiring: @cgdev.org’s @uchi-msa.bsky.social is looking for a Research Assistant to help develop market-shaping proposals tackling global health, climate change, pandemic preparedness & other pressing challenges. 📍 Washington DC 📅 Apply by Oct 15 go.cgdev.org/4d18Okr
centerforglobaldevelopment.applytojob.com
Research Assistant – Market Shaping Accelerator - Center for Global Development - Career Page
Apply to Research Assistant – Market Shaping Accelerator at Center for Global Development in Washington, DC.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 13/08/2026
At MSA, we're designing AMCs and prizes to pull innovation toward diseases that need it—and ensure it reaches patients. Check out our portfolio of pull mechanisms in @leahrosenzweig.bsky.social's recent blog: www.cgdev.org/blog/ai-phil...
cgdev.org
AI Philanthropy Should Buy the Breakthroughs Markets Won’t
In the first blog in this series, Rachel Glennerster and I suggested that new philanthropists could spend tens of billions of dollars on proven cost-effective interventions. This blog is about buying ...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 13/08/2026
Excited to see pull mechanisms featured in @scientificdiscovery.dev's recent WIP article. Her framing is one we use ourselves: the binding constraint often isn't science, but incentives.
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Leah Rosenzweig @leahrosenzweig.bsky.social · 27/07/2026
Can $50 billion a year in new philanthropy be spent well? We think so! @rglenner.bsky.social and I suggest institutions that could move money at that scale toward cost-effective programs.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 10/08/2026
📢 #WereHiring: MSA is seeking a Fellow or Senior Fellow to lead research on market shaping and innovation policy. Join us to deliver innovative solutions to global challenges! 📅First application review deadline: November 1. centerforglobaldevelopment.applytojob.com/apply/nDb6lM...
centerforglobaldevelopment.applytojob.com
Fellow/Senior Fellow, Market Shaping Accelerator - Center for Global Development - Career Page
Apply to Fellow/Senior Fellow, Market Shaping Accelerator at Center for Global Development in Washington, DC.
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Center for Global Development @cgdev.org · 10/08/2026
📢 #WereHiring: @cgdev.org's @uchi-msa.bsky.social is seeking a Fellow or Senior Fellow to lead research on market shaping and innovation policy. 📅 Rolling applications, first review deadline: November 1. go.cgdev.org/3TNp420
centerforglobaldevelopment.applytojob.com
Fellow/Senior Fellow, Market Shaping Accelerator - Center for Global Development - Career Page
Apply to Fellow/Senior Fellow, Market Shaping Accelerator at Center for Global Development in Washington, DC.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 07/07/2026
A proposed advance market commitment could save newborn lives. This new MSA and @cgdev.org report sets out the plan to accelerate rapid diagnostics for neonatal sepsis. Now, the team is raising the $60M💰 needed to launch it.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 11/06/2026
IFP and MSA thank the Center for Incentive Design, the Smith Richardson Foundation, and the Sijbrandij Foundation for their support of this project.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 11/06/2026
Last week, MSA launched the Atlas of Innovation with @ifp.bsky.social. The Atlas helps policymakers, philanthropists, and development banks choose HOW to fund innovation. Today’s blog post describes why we made the Atlas and how it works: www.marketshapingaccelerator.org/research/the...
marketshapingaccelerator.org
The Atlas of Innovation: A New Tool for Navigating the Innovation Funding Landscape - Market Shaping Accelerator
By Sarrin Chethik, Siddhartha Haria, and Christopher Snyder The United States government spends close to $200 billion annually on research and development. Every dollar counts, as innovation is crucia...
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Center for Global Development @cgdev.org · 04/06/2026
Neonatal sepsis kills 700,000 newborns every year — one baby every 45 seconds. A joint @cgdev.org and @uchi-msa.bsky.social working group is launching an advance market commitment to spur the development of affordable, accurate rapid diagnostic tests for neonatal sepsis. cgdev.org/project/neotest
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 02/06/2026
Choosing how to fund innovation can be just as important as choosing what to fund. The Atlas of Innovation helps policymakers and philanthropies navigate the tradeoffs between 13 funding approaches—from grants to prizes to advance market commitments. 🧭 Explore the tool: atlasofinnovation.org/
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 13/11/2025
See more from @rglenner.bsky.social and @cgdev.org colleagues here: www.cgdev.org/blog/five-st...
cgdev.org
Five Steps MDBs Can Take Now to Unlock Pandemic Financing
Much of the delay in COVID-19 vaccine deliveries to LMICs resulted from their signing purchase agreements later than high-income countries. These lags in part reflect the restrictive lending criteria ...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 13/11/2025
Recommendations: nam.edu/wp-content/u... Report: nam.edu/wp-content/u...
nam.edu
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 13/11/2025
New G20 High Level Independent Panel on pandemic preparedness out. Recommendation 3: Enabling at-risk financing for low and middle income countries is crucial to ensuring low and middle income countries get the vaccines and therapeutics they need during the next outbreak
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Reposted by Market Shaping Accelerator (MSA)
CARB-X @carb-x.bsky.social · 16/07/2025
CARB-X Executive Director @koutterson.bsky.social joined a working group convened by @cgdev.org and @uchi-msa.bsky.social that aims to develop an advance market commitment for a rapid diagnostic test for neonatal sepsis in LMICs. 🧪 #IDSky 🔗 Read here: bit.ly/44ku4xJ
bit.ly
Why Expertise Matters: Building the Coalition to Launch Our Neonatal Sepsis AMC
This blog post is the third in a series introducing a new working group convened by CGD and the Market Shaping Accelerator (MSA) on developing an advance market commitment (AMC) for a rapid diagnostic test for neonatal sepsis in low- and middle-income countries.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
More in our blog post series with @cgdev.org: 🔗 www.cgdev.org/blog/why-exp... @siddhharia.bsky.social
cgdev.org
Why Expertise Matters: Building the Coalition to Launch Our Neonatal Sepsis AMC
This blog post is the third in a series introducing a new working group convened by CGD and the Market Shaping Accelerator (MSA) on developing an advance market commitment (AMC) for a rapid diagnostic...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
Done right, we believe this AMC can help bring a game-changing diagnostic to market that tackles neonatal sepsis and antibiotic resistance at once. If you’re interested in shaping this work—whether as a funder, policymaker, developer, or implementer—we’d love to hear from you.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
The working group’s efforts will also create valuable public goods. Clear TPPs and evidence requirements, market assessments, and health economic modeling can aid broader diagnostics efforts. It can also inform how to de-risk other valuable global health innovations.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
🤝 Mobilizing funding An AMC is only as strong as the coalition behind it. We’re generating evidence on cost-effectiveness and AMR impact to show countries, donors, and implementers why this is a high-value, neglected opportunity worth investing in.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
🌍 Country engagement The AMC would provide a demand signal, but clear regulatory pathways and procurement plans from LMICs are needed to make such signals credible. As such, we’re mapping what’s needed to get diagnostics widely implemented across different health systems.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
🔧AMC design means answering questions such as: - What kind of test should we target? - How will we validate its quality and use? - What should we pay, and how should payments be structured? These questions are deeply technical and interdependent, and thus require interdisciplinary expertise.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
We’re convening global health leaders, industrial organization economists, diagnostics experts, and policymakers—chaired by Lord Jim O’Neill—to tackle three tasks: 🔧 AMC design 🌍 Country engagement 🤝 Mobilizing funding
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
In our earlier posts, we outlined the scale of the problem and why market failures have stalled innovation. In this one, we turn to how we’re planning to fix it: by launching a working group to design an effective AMC that can deliver results.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 27/06/2025
An Advance Market Commitment (AMC) for neonatal sepsis diagnostics could save newborn lives and curb antibiotic resistance. But how should such an AMC actually work? And how will we get it off the ground? 🧵
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
📖 Read our post to learn more: 🔗 www.cgdev.org/blog/when-ma... @siddhharia.bsky.social
cgdev.org
When Markets Fail Newborns: The Case for an Advance Market Commitment for Neonatal Sepsis Diagnostics
This blog post is the second in a series introducing a new working group convened by CGD and the Market Shaping Accelerator (MSA) on developing an advance market commitment for a rapid diagnostic test...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
We're developing the “NeoTest” AMC under a @cgdev.org -led working group. We're defining TPPs, modeling cost-effectiveness and market potential, and laying the foundations for future procurement.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
Our AMC proposal specifically targets the market failures we’ve outlined: ✅ Rewards early movers ✅ Pricing commitment dissolves the hold-up problem ✅ Increased payments partially compensate for the social value of reduced AMR
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
An AMC brings several advantages: 🔬 Tech-agnostic—welcoming biomarkers, metagenomics, machine learning, and more 📋 Tied to real-world needs via a target product profile (TPP) 🌍 Linked to affordability to ensure access where it’s needed most
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
To overcome these challenges, we propose an advance market commitment (AMC): a pull mechanism in which funders commit upfront to pay for products that meet real-world criteria. For neonatal sepsis, this could mean top-up payments per qualifying test or guaranteed purchase volumes at a fixed price.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
3️⃣ AMR spillovers: Only ~18% of neonates treated for sepsis in LMICs have a confirmed infection. The rest still receive antibiotics, fueling resistance. Better diagnostics could change that. But health systems underinvest because AMR reductions help others, not just the payer.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
2️⃣ Pricing constraints: Neonatal sepsis predominantly affects low-resource countries. Here, limited health budgets and concentrated purchasing power often drive prices down to marginal cost, making it hard to recoup R&D investment. This is a classic case of a hold-up problem.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
1️⃣ First-mover disadvantage: Pioneering a new sepsis diagnostic involves high R&D costs, navigating uncertain regulation, and building demand from scratch. But weak IP protections and industry-wide spillovers allow later entrants to compete away profits, undermining the incentive to invest.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
Despite clear need and promising scientific leads, no rapid, point-of-care neonatal sepsis test has reached the market. Why? Three overlapping market failures disincentivize investment. 👇
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
In our last post, we explained why rapid diagnostics for neonatal sepsis are a high-value innovation target: they can catch infections early and reduce unnecessary antibiotic use. 📖 www.cgdev.org/blog/case-pr...
cgdev.org
The Case for Prioritizing Neonatal Sepsis Diagnostics
This blog post is the first in a series introducing a new working group convened by CGD and the Market Shaping Accelerator (MSA) on developing an advance market commitment (AMC) for a rapid diagnostic...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 26/06/2025
A rapid diagnostic for neonatal sepsis could save newborn lives and reduce antibiotic resistance - but no such test exists yet. What’s blocking progress? 🧵
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
📖 Learn more in our blog post—the first in a new series on how an AMC could unlock progress on this critical front: www.cgdev.org/blog/case-pr... @siddhharia.bsky.social @rrolapp.bsky.social @cgdev.org
cgdev.org
The Case for Prioritizing Neonatal Sepsis Diagnostics
This blog post is the first in a series introducing a new working group convened by CGD and the Market Shaping Accelerator (MSA) on developing an advance market commitment (AMC) for a rapid diagnostic...
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
Neonatal sepsis diagnostics are a promising solution to prevent newborn deaths and reduce the incidence of antimicrobial resistance. Our working group with @CGDev is building the incentives to bring them to market.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
Nonetheless, diagnostics remain underfunded. Just 8% of AMR R&D funding goes to diagnostics. And yet, promising solutions are advancing—biomarkers, molecular tests, metagenomics, and AI-based tools are already in development.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
Sensitive, specific rapid diagnostics would save lives by catching infections early and reducing antibiotic overuse. They’re a recognized global priority: the WHO has outlined needs for neonatal sepsis diagnostics, and frontline providers in LMICs have emphasized their importance.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
Already, over 30% of neonatal sepsis deaths are attributable to first-line antibiotic-resistant infections. Antimicrobial resistance (AMR) more broadly is linked to nearly five million deaths globally each year. The need for better tools to guide antibiotic use is urgent.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
As a result, clinicians must act based on ambiguous symptoms. This leads to preventable deaths from missed diagnoses and unnecessary antibiotic use that drives antimicrobial resistance (AMR).
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
Neonatal sepsis kills 400-700k newborns every year. It’s treatable with antibiotics—if diagnosed in time. But current tests take 48–72 hours, too long to guide life-saving initial treatment decisions.
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
In collaboration with @CGDev, we’re establishing a working group to design an Advance Market Commitment (AMC) for a rapid diagnostic for neonatal sepsis—a devastating and neglected cause of child mortality. Here’s why this is our focus. 🧵👇
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Market Shaping Accelerator (MSA) @uchi-msa.bsky.social · 25/06/2025
Developing a rapid diagnostic could save thousands of newborn lives and slow AMR. Read the full series to learn more: www.cgdev.org/blog/case-pr... @siddhharia.bsky.social @cgdev.org @rrolapp.bsky.social
cgdev.org
The Case for Prioritizing Neonatal Sepsis Diagnostics
This blog post is the first in a series introducing a new working group convened by CGD and the Market Shaping Accelerator (MSA) on developing an advance market commitment (AMC) for a rapid diagnostic...
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