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Typas Lab

@typaslab.bsky.social

2.8K followers 672 following 50 posts

Systems Microbiology @EMBL, combining high-throughput approaches & mechanism in bacteria, antibiotics, microbiome, infection, species diversity, cell envelope www.embl.org/groups/typas

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Typas Lab @typaslab.bsky.social · 20/08/2026

Among many additions since the preprint: a divergent DFG-like (DPV) motif that likely locks T7K in the ON mode, and the discovery of T7K homologues in jumbophages.

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Typas Lab @typaslab.bsky.social · 20/08/2026

This function was missed for ~50y b/c T7 biology was mainly explored in lab strains w/ few defenses. Our infection assays in natural isolates show strong phenotypes for T7K; it allows T7 to infect strains that carry diverse systems but share no common one, through a brute-force deactivation strategy

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Typas Lab @typaslab.bsky.social · 20/08/2026

Mechanistically, T7K’s C-terminal DNA-binding domain steers this activity towards DNA/RNA-binding proteins (building blocks of most defense systems). We map phosphorylation of Retron-Eco9 by T7K at critical residues; single phosphomimetic mutations at these T7K-modified sites abolish defense.

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Typas Lab @typaslab.bsky.social · 20/08/2026

Most known phage anti-defenses proteins block a single system. T7K is different: a hyper-promiscuous, dual-specificity kinase that phosphorylates nearly all host proteins in a short, early burst in infection, with no clear sequence motif.

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Typas Lab @typaslab.bsky.social · 29/06/2026

How can we harness the vast functional diversity of microbes on our planet? Join us at EMBL Heidelberg from 8–10 December 2026 to hear about ongoing efforts to decode gene function and organisation in human gut microbes, and to present your own research. www.embl.org/about/info/c...

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Typas Lab @typaslab.bsky.social · 29/04/2026

We found that E. coli can be a key driver of selection for a high-fitness antibiotic resistant K. pneumoniae strain in complex communities. Higher-order interactions with other community members could enhance or decrease the selective advantage of the resistant mutant.

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Typas Lab @typaslab.bsky.social · 29/04/2026

We introduce a high-throughput method to quantify resistance-associated fitness costs inside complex gut microbiomes. This lets us identify which microbiota are permissive or restrictive for antibiotic-resistant pathogens.

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Typas Lab @typaslab.bsky.social · 13/10/2025

Excited to share our preprint led by Carlos Voogdt et al We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera. www.biorxiv.org/content/10.1...

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Typas Lab @typaslab.bsky.social · 23/06/2025

Excited for New Approaches and Concepts in Microbiology 2025 with sessions on Bacterial systems biology, Bacterial cell biology & protein machines, Microbiomes, Environment & evolution, Pathogenesis & phage, Antibiotic discovery, mechanisms, and resistance. #EESMicrobiology

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Typas Lab @typaslab.bsky.social · 26/03/2025

Join our favorite microbiology meeting! Fantastic talks, poster sessions, new technologies, and all the hot areas of microbiology in a great environment - experts in cell & systems biology, microbiomes, environment & evolution, pathogenesis, phage & antibiotics DON’T MISS abstract deadline, April 1

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Typas Lab @typaslab.bsky.social · 16/12/2024

You want to learn about microbiology from a fantastic lineup of speakers on a beautiful Greek island? PhD students apply now for the @EMBO | @FEBSnews Lecture Course The New Microbiology! Registration: 1 Apr 2025 Course: 03 – 11 Sep 2025 | Spetses, Greece meetings.embo.org/event/25-new...

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