iiinova — where your digital self keeps evolving

Turlier lab @turlierlab.bsky.social · 24/07/2026

A central result: cadherin-dependent adhesion contributes significantly to cell-cell tension in C. elegans, with a highly non-linear, Hill-like dependence. Adhesion is not just a small correction to contractility.

120

Turlier lab @turlierlab.bsky.social · 24/07/2026

Inside the eggshell, the model predicts morphogenesis quantitatively: anterior compaction is driven by rising cell-medium tension, while P2’s early exclusion reflects high cell-cell contact tension. 5/6

100

Turlier lab @turlierlab.bsky.social · 24/07/2026

To calibrate inferred tensions, we combined AFM measurements with cortical myosin intensity. AB-lineage cells are more tense than P-lineage cells, and tension rises dynamically through the cell cycle. 4/6

100

Turlier lab @turlierlab.bsky.social · 24/07/2026

We combined live imaging, contact-angle measurements and tension inference to reconstruct relative surface tensions, then used a 3D active foam model to predict embryo shape over time. 3/6

100

Turlier lab @turlierlab.bsky.social · 24/07/2026

The early C. elegans embryo is not mechanically uniform. Removing the eggshell, one can observe that at the 4-cell stage, ABa, ABp and EMS compact together, while P2 initially remains partly excluded — revealing dynamic, lineage-specific mechanics. 2/6

100

Turlier lab @turlierlab.bsky.social · 24/07/2026

Very happy to have this work finally published! How do embryos sculpt their shape? We map the contractile & adhesive forces shaping early C. elegans embryos. With K. Yamamoto @ittoku04.bsky.social G. Charras' lab @gcharras.bsky.social & my team @turlierlab.bsky.social shorturl.at/xv7G5 1/6

14315

Reposted by Turlier lab

Evan Bardot (he/him) @ebardot.bsky.social · 13/07/2026

I had the chance to highlight some amazing #DevBio from @gcharras.bsky.social and @herveturlier.bsky.social for @natcellbio.nature.com this month! Check out my Research Highlight www.nature.com/articles/s41... and the original article in @cp-devcell.bsky.social www.sciencedirect.com/science/arti...

nature.com

Relative tension shapes embryos - Nature Cell Biology

Nature Cell Biology - Relative tension shapes embryos

1228

Reposted by Turlier lab

CNRS Biologie @cnrsbiologie.bsky.social · 10/07/2026

#ResultatScientifique🔎| Une étude révèle comment les forces mécaniques façonnent l’embryon précoce de C. elegans grâce à une nouvelle cartographie spatio-temporelle des tensions cellulaire ▶️ buff.ly/olJR46F 📕 @cp-devcell.bsky.social 🤝 @CNRS.fr

buff.ly

Cartographier les forces qui sculptent l’embryon

Comment quelqu

0124

Turlier lab @turlierlab.bsky.social · 29/06/2026

Great scientific times with @bimidu.bsky.social at @columbiauniversity.bsky.social. Many thanks for your warm welcome and inspiring chats. Looking forward to more interactions!

130

Turlier lab @turlierlab.bsky.social · 19/06/2026

How did you get them in very high image quality in the end?

100

Reposted by Turlier lab

Henry De Belly @henrydebelly.bsky.social · 19/06/2026

We made the cover 🤩 !! Check out this incredible painting by @kahsage.bsky.social !!

3669

Turlier lab @turlierlab.bsky.social · 10/06/2026

Very glad to see this great transatlantic collaborative work published 🎉! Congratulations to all authors: @henrydebelly.bsky.social, @andreu Fernandez Gallén, @ericneiva.bsky.social, and @oweinerlab.bsky.social Funding from MSCA @ec.europa.eu & @cnrsbiologie.bsky.social

081

Reposted by Turlier lab

SFB 1348 @sfb1348.bsky.social · 13/05/2026

The @sfb1348.bsky.social Meeting “Mechanochemical Signals at Cellular Interfaces” is just around the corner! We are excited to welcome an outstanding lineup of international speakers to #Münster for three days of inspiring scientific exchange and discussion. @uni-muenster.de

13113

Turlier lab @turlierlab.bsky.social · 20/04/2026

A real computational tour de force by @ericneiva.bsky.social, carried out as Marie Skłodowska-Curie postdoctoral fellow in the team, now published in the Journal of Computational Physics: urlr.me/AuzK86 Congratulations, Eric! @cnrsbiologie.bsky.social Grateful to @ec.europa.eu for funding support

0217

Turlier lab @turlierlab.bsky.social · 12/04/2026

We hope VertAX can help make inverse problems & differential programming more accessible in tissue mechanics. Thanks to @apasqui.bsky.social, Maxence Ernoult, Italian colleagues, and other members of the team for this collaboration. Comments very welcome. Code: github.com/VirtualEmbry... 5/5

github.com

GitHub - VirtualEmbryo/VertAX: A differentiable JAX-based framework for vertex modeling and inverse design of epithelial tissues

A differentiable JAX-based framework for vertex modeling and inverse design of epithelial tissues - VirtualEmbryo/VertAX

010

Turlier lab @turlierlab.bsky.social · 12/04/2026

Beyond synthetic benchmarks, we show applications to mechanical parameter inference from microscopy images and to inverse design problems in epithelial tissues. 4/5

110

Turlier lab @turlierlab.bsky.social · 12/04/2026

We benchmark three strategies for bilevel optimization in vertex models: automatic differentiation, implicit differentiation, and equilibrium propagation. This gives a practical comparison of their accuracy, speed, and memory trade-offs. 3/5

110

Turlier lab @turlierlab.bsky.social · 12/04/2026

VertAX unifies forward modeling and inverse modeling in the same framework. It lets users define custom energy functions and cost functions in pure Python, while leveraging JAX and bilevel optimization for differentiation, JIT compilation, and GPU acceleration. 2/5

100

Turlier lab @turlierlab.bsky.social · 12/04/2026

How can we learn tissue mechanics directly from cell patterns and images? In our new preprint, we introduce VertAX, a differentiable vertex-model framework in JAX for simulating epithelia, inferring parameters, and designing target tissue behaviors. shorturl.at/PUzT0 1/5

15221

Reposted by Turlier lab

FocalPlane @focalplane.bsky.social · 07/04/2026

The abstract deadline for the CSHL Cell Modeling in Space and Time is this Friday 10 April. Don’t miss out!

focalplane.biologists.com

Cell Modeling in Space and Time at CSHL - FocalPlane

Cell Modeling in Space and Time at CSHL -

022

Turlier lab @turlierlab.bsky.social · 13/03/2026

Glad to see our work discussed in Quanta Magazine shorturl.at/VXa7E. In the early embryo, building a cavity can start by “fracturing” cell-cell contacts, creating microlumens that then coarsen into a single cavity. @cnrsbiologie.bsky.social

shorturl.at

Break It To Make It: How Fracturing Sculpts Tissues and Organs | Quanta Magazine

Growing tissues can crack, break, and dissociate to form structures that can later withstand immense forces.

180

Turlier lab @turlierlab.bsky.social · 13/03/2026

Excited to start a new chapter with my team’s relocation to the Pink City, at @cbitoulouse.bsky.social! Looking forward to new scientific interactions on campus (@laas, LPT, IRIT, ANITI…) at the interface of biology, physics & computational science. @cnrsbiologie.bsky.social @occitanie.bsky.social

5245

Turlier lab @turlierlab.bsky.social · 20/01/2026

How does a ball of cells become an embryo? Genes matter—but physics (forces, geometry, topology) drives self-organization. Hervé Turlier's research vision on the physics of embryogenesis👇 shorturl.at/761x9 #Embryogenesis #Biophysics #Morphogenesis @college-de-france.fr @cnrsbiologie.bsky.social

041

Reposted by Turlier lab

Barone Lab @baronelab.bsky.social · 07/07/2025

This postdoc position is still open! Apply if you want to come work with us on asymmetric cell divisions in spiralian embryos! postdocs.stanford.edu/prospective/...

postdocs.stanford.edu

Open Postdoctoral position, faculty mentor Vanessa Barone | Office of Postdoctoral Affairs

03127

Turlier lab @turlierlab.bsky.social · 25/06/2025

Our first paper submitted to the International Conference on Computer Vision @iccv.bsky.social has been accepted! 🎉 Huge congratulations to all co-authors — Sacha Ichbiah, Anshuman Sinha, and Fabrice Delbary — for their fantastic work. Stay tuned… we’ll share more about deltaMic in a few days!

0143

Reposted by Turlier lab

Barone Lab @baronelab.bsky.social · 28/05/2025

Job Alert! We are recruiting one postdoc to work on spiralian embryos and their crazy polar lobes. More info about this HFSP-funded position on our website baronelab.org: scroll to the end, click on "this could be you"...start your adventure!

37947

Turlier lab @turlierlab.bsky.social · 19/05/2025

Great time with @sugimuralab.bsky.social, Shuji Ishihara and colleagues at Tokyo University 🇯🇵. Thank you for your very kind welcome and great scientific discussions 🙂

040

Turlier lab @turlierlab.bsky.social · 16/05/2025

Very excited to share a new preprint by @ericneiva.bsky.social who developed a first-of-its-kind finite element method for simulating 3D cellular dynamics with coupled surface–bulk flows and signaling. A technical tour de force with broad applications in mechanobiology & beyond tinyurl.com/bdfhfke3

0134

Turlier lab @turlierlab.bsky.social · 23/04/2025

First post on bsky for a very good news. Very glad to be awarded this HFSP with @chemamd.bsky.social & @baronelab.bsky.social to study the evolutionary biophysics of spiralian early asymmetric divisions ! @hfspo.bsky.social @cnrsbiologie.bsky.social @collegedefrance.bsky.social @cirbcdf.bsky.social

1236