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Paul Tuite

@tuite002.bsky.social
525 followers 226 following 912 posts

Prof Neurology U MN /biomarkers/pharmacodynam/Parkinson’s/PSP/LBD/therapeutics/MR

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Reposted by Paul Tuite
The Science of Parkinson's @scienceofpd.bsky.social · 07/10/2026
Researchers screening "nutrients & metabolites" found that l-Arginine inhibits NLRP3 inflammasome assembly in vitro. It binds to the Asp31 site of the NLRP3 protein, blocking its interaction with ASC. L-Arginine levels significantly⬇️in #Parkinsons serum www.nature.com/articles/s42...
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Paul Tuite @tuite002.bsky.social · 08/10/2026
He’s the Most Powerful Engineer on Earth. Here’s Why He Thinks A.I. Is Going Great. www.nytimes.com/2026/10/07/o...
nytimes.com
Opinion | Jensen Huang Thinks A.I. Is Going Great (Gift Article)
Our fate may be very well be in the hands of Jensen Huang.
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Paul Tuite @tuite002.bsky.social · 06/10/2026
They Kept Outsiders Away for 500 Years. Their World Is About to Change. www.nytimes.com/2026/09/23/m...
nytimes.com
They Kept Outsiders Away for 500 Years. Their World Is About to Change. (Gift Article)
My father dedicated his life to studying the Guna people of Panama, and they may soon allow unprecedented development through their land. I went on a trek through the jungle to find out why.
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Reposted by Paul Tuite
The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026
A new review on chaperone-mediated autophagy in physiological homeostasis, disease & ageing has been publisehed; #Parkinsons gets a couple of mentions, but a useful overview of the biology & potential "gerotherapeutic" targets www.nature.com/articles/s41...
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Reposted by Paul Tuite
Sen. Adam Schiff @schiff.senate.gov · 06/10/2026
You spoke out, and he backed down. Now let’s see the proof this illegal waste of your taxes is over for good. And that he pays the money back. We don’t want the U.S. taxpayers to be the latest contractors to get stiffed.
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 05/10/2026
RFK Jr. thinks that getting measles is no big deal, and points to the low death rate to support this asinine opinion. Besides the fact that these deaths are preventable, he ignores hospitalizations and immune amnesia, which can erase immunity to other pathogens that people have already built up.
cidrap.umn.edu
Measles outbreaks could leave thousands vulnerable to infectious diseases for years
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Reposted by Paul Tuite
Minnesota Star Tribune @startribune.com · 06/10/2026
Travis Meier’s run in the Twin Cities Marathon — while carrying a canoe — was a show of support for the Boundary Waters and a protest against a proposal to mine copper and nickel near the wilderness.
startribune.com
Who was the marathon canoe guy and ... why?
Runner Travis Meier of Minneapolis took an unorthodox — and prohibited — route in his Twin Cities Marathon-based statement about the Boundary Waters.
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Reposted by Paul Tuite
Karl Deisseroth @deisseroth.bsky.social · 05/10/2026
Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections
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Paul Tuite @tuite002.bsky.social · 05/10/2026
I Know Christa Pike’s Medical History. What Tennessee Did Is Unforgivable. www.nytimes.com/2026/10/04/o...
nytimes.com
Opinion | I Consulted With Christa Pike’s Death Row Team. I Knew This Could Happen. (Gift Article)
Lethal injection failures are not glitches; they are features of the process.
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Paul Tuite @tuite002.bsky.social · 05/10/2026
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson’s disease: a randomized double-blind prospective study
Parkinson’s disease is associated with a dysbiotic, proinflammatory gut microbiome, disruptions to intestinal barrier functions, and immunological imbalance. Microbiota-produced short-chain fatty acid...
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Paul Tuite @tuite002.bsky.social · 05/10/2026
www-nature-com.ezp2.lib.umn.edu/articles/s41...
www-nature-com.ezp2.lib.umn.edu
Shibboleth Authentication Request
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Paul Tuite @tuite002.bsky.social · 05/10/2026
www.nature.com/articles/s41...
nature.com
Machine learning-based meta-analysis reveals gut microbiome alterations associated with Parkinson’s disease - Nature Communications
Here, the authors perform a machine learning meta-analysis of Parkinson’s disease (PD) classification based on microbiome features, showing that the accuracy of models can be generalizable and improve...
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Paul Tuite @tuite002.bsky.social · 05/10/2026
pmc-ncbi-nlm-nih-gov.ezp2.lib.umn.edu/articles/PMC...
pmc-ncbi-nlm-nih-gov.ezp2.lib.umn.edu
Shibboleth Authentication Request
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Paul Tuite @tuite002.bsky.social · 05/10/2026
pmc-ncbi-nlm-nih-gov.ezp2.lib.umn.edu/articles/PMC...
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Paul Tuite @tuite002.bsky.social · 05/10/2026
pmc-ncbi-nlm-nih-gov.ezp2.lib.umn.edu/articles/PMC...
pmc-ncbi-nlm-nih-gov.ezp2.lib.umn.edu
Shibboleth Authentication Request
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Paul Tuite @tuite002.bsky.social · 05/10/2026
pubmed-ncbi-nlm-nih-gov.ezp2.lib.umn.edu/42706618/ Co- and multipathologies need serious consideration for understanding Parkinson's disease pathogenesis and designing novel experimental therapeutic strategies Ashley Boehringer et al. J Parkinsons Dis. 2026.
pubmed-ncbi-nlm-nih-gov.ezp2.lib.umn.edu
Shibboleth Authentication Request
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Paul Tuite @tuite002.bsky.social · 03/10/2026
Agency Diverted $1.4 Billion in Science Funds Mandated by Congress www.nytimes.com/2026/10/02/u...
nytimes.com
National Science Foundation Diverted $1.4 Billion in Science Funds Mandated by Congress (Gift Article)
The move, affecting about one-fifth of the National Science Foundation’s primary research budget, is the latest sign of how the White House is asserting more control over grants.
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Reposted by Paul Tuite
NPR @npr.org · 01/10/2026
Disability rights advocates are angered by the latest reversal but are rallying behind proposed legislation and working with states to strengthen protections for community integration. trib.al/teEenpZ
trib.al
Trump administration reverses stance on integration of people with disabilities
Disability rights advocates are angered by the latest reversal but are rallying behind proposed legislation and working with states to strengthen protections for community integration.
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Reposted by Paul Tuite
The Lincoln Project @lincolnproject.us · 01/10/2026
⁨Arizona was hit hardest by SNAP cuts. A 52% reduction in recipients - that's 400,000 people, including hungry children, who have been kicked off assistance. Juan Ciscomani voted for this in the BBB and expects Arizonans to forgive him?⁩
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Paul Tuite @tuite002.bsky.social · 28/09/2026
www.nature.com/articles/s42...
nature.com
Hyperglycosylation is a metabolic driver of Alzheimer’s disease - Nature Metabolism
Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic ta...
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Paul Tuite @tuite002.bsky.social · 28/09/2026
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2026/09/27/u...
nytimes.com
A Trump 2024 Campaign Ad Returns, Now Brought to You by the Government (Gift Article)
The ad, which ethics experts said could violate federal law, shows Mr. Trump vowing to “expel the warmongers” from the government and fight the “deep state,” even as he wages a war with Iran.
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Reposted by Paul Tuite
Wes Burdine @wesburdine.bsky.social · 27/09/2026
Jesus Christ
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Reposted by Paul Tuite
Ian Kremer @wolverinebear.bsky.social · 27/09/2026
Trump Administration Plans to Gut Clean Car Rules www.nytimes.com/2026/09/26/c... #Project2025 #DOT #EPA #environment #pollution #climate #Blues
nytimes.com
Trump Administration Plans to Gut Clean Car Rules (Gift Article)
New fuel-economy standards, which President Trump said he finalized Saturday, would kill a federal effort to speed the transition to electric vehicles.
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Paul Tuite @tuite002.bsky.social · 27/09/2026
What Hegseth Is Hiding www.nytimes.com/2026/09/24/o...
nytimes.com
Opinion | What Hegseth Is Hiding (Gift Article)
Soldiers want to tell their stories, and we need to hear them.
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Reposted by Paul Tuite
Wes Burdine @wesburdine.bsky.social · 27/09/2026
I feel bad for Cam. Seems like a decent fellow, but MNUFC need to fire him tomorrow and give Danny Cruz a run out to the end of the season to see if he's a real option
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Paul Tuite @tuite002.bsky.social · 27/09/2026
It’s Raining Boxes: Amazon Drones Overwhelm a Texas Suburb www.nytimes.com/2026/09/21/u... Coming to your area
nytimes.com
It’s Raining Boxes: Amazon Drones Overwhelm a Texas Suburb (Gift Article)
In Richardson, a fleet of drones has started to deliver goods quickly. But the noise is drowning out life for some residents: ‘We can’t live like this.’
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Paul Tuite @tuite002.bsky.social · 26/09/2026
www.startribune.com/youth-sports...
startribune.com
Yuen: He helped build the youth sports machine. Now he’s trying to fix it.
Ted Kroeten once embraced domes, drills and cutthroat tryouts. Now he lets children lead, and his soccer club produces champions.
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Paul Tuite @tuite002.bsky.social · 26/09/2026
The Four Midterm Races That Matter Most www.nytimes.com/2026/09/25/o...
nytimes.com
Opinion | The Four Midterm Races That Matter Most (Gift Article)
Four swing states will soon elect the official who will run the 2028 presidential election. The candidates are alarming.
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Reposted by Paul Tuite
Ali Christy, MD, PhD @oligoclonalband.medsky.social · 26/09/2026
Are you making games for education? This is a great talk! Actually @empiricgame.bsky.social has several great talks on the MedEd GAMER channel. Also, you should consider joining us in GANGLIA, a year long program in game and curriculum development (neurdgames.com/ganglia).
neurdgames.com
GANGLIA | Neurd Games
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Paul Tuite @tuite002.bsky.social · 26/09/2026
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2026/09/26/h...
nytimes.com
‘Zombified’ C.D.C., Hobbled by Cuts, Struggles to Fulfill Scientific Mission (Gift Article)
The agency has lost its independence and nearly a third of its staff, as Health Secretary Robert F. Kennedy Jr. and associates have tightened control.
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Paul Tuite @tuite002.bsky.social · 25/09/2026
Unused Tents and Uneaten Food: Watchdog Finds ‘Waste’ in Immigration Crackdown www.nytimes.com/2026/09/24/u...
nytimes.com
Unused Tents and Uneaten Food: Watchdog Finds ‘Waste’ in Immigration Crackdown (Gift Article)
In a report Thursday, the Government Accountability Office said the Trump administration squandered millions of dollars to expand detention.
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Paul Tuite @tuite002.bsky.social · 25/09/2026
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2026/09/24/u...
nytimes.com
Abortion Pills, Vaccines and Food Safety: F.D.A. Nominee Heidi Overton Faces Senate Confirmation Hearing (Gift Article)
Dr. Heidi Overton was pressed on the president’s false statements about the measles vaccine and his intervention in tobacco policy.
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Paul Tuite @tuite002.bsky.social · 25/09/2026
Communism terrible Plutocracy good
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Paul Tuite @tuite002.bsky.social · 24/09/2026
A Reclusive G.O.P. Billionaire Pulls Back His Money From Senate Republicans www.nytimes.com/2026/09/23/u... Or rather classist oppression by billionaire failed to pass
nytimes.com
Timothy Mellon, a G.O.P. Billionaire, Pulls Back His Money From Senate Republicans (Gift Article)
Timothy Mellon, one of the party’s biggest donors in 2024, has so far withheld his midterm donations for Republican senators because he is unhappy about the failure to pass a key Trump priority.
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Reposted by Paul Tuite
Sheryl Gay Stolberg @sherylnyt.bsky.social · 23/09/2026
Idea for a White House commission to control NIH grant approvals seems dead for now. Weekend stories created an uproar on the Hill. Bhattacharya and Vought are trying to sing kumbaya. w/ @by-cjewett.bsky.social www.nytimes.com/2026/09/23/u...
nytimes.com
Trump Backtracks on Plan for New Controls on N.I.H. Grants (Gift Article)
Democrats and Republicans in Congress opposed the creation of a commission with the power to veto federal research awards.
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Paul Tuite @tuite002.bsky.social · 23/09/2026
How Scientists Contained a Threat That Could Have Destroyed Humanity www.nytimes.com/2026/09/23/u...
nytimes.com
How Scientists Contained a Threat That Could Have Destroyed Humanity (Gift Article)
A half-century ago, scientists and lawyers agreed to strict self-regulation in DNA research to avoid catastrophe. But it took enforcement to really stop them.
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Paul Tuite @tuite002.bsky.social · 23/09/2026
thehill.com/policy/defen... He has no idea if this is a valid way to determine anything - if he truly wants to see if his approach is better he would take a scientific and comparative design of assessing people rather than his style which is as biased as others.
thehill.com
Hegseth announces new Pentagon battlefield test for promotions to general
The Pentagon is altering the promotion process to get to the rank of general in an effort to “cut bureaucracy and demand true meritocracy” across the senior ranks, Defense Secretary Pete Hegseth an…
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Paul Tuite @tuite002.bsky.social · 21/09/2026
Trump Has Finally Lost the Plot www.nytimes.com/2026/09/19/o...
nytimes.com
Opinion | Trump Has Finally Lost the Plot (Gift Article)
It is now apparent that many Americans — probably enough Americans — are determined to live within the truth rather than the lie.
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Paul Tuite @tuite002.bsky.social · 21/09/2026
White House Moves to Take Control of N.I.H. Grants www.nytimes.com/2026/09/20/s...
nytimes.com
White House Moves to Take Control of N.I.H. Grants (Gift Article)
Federal officials are drafting an executive order that would place grants under review by an outside panel, the latest effort to redirect billions of dollars in research spending.
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Paul Tuite @tuite002.bsky.social · 21/09/2026
Vance Has a Twisted Idea of What It Means to Be American www.nytimes.com/2026/09/20/o...
nytimes.com
Opinion | Vance Has a Twisted Idea of What It Means to Be American (Gift Article)
I am a “heritage American,” too. How should that guide my life?
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Paul Tuite @tuite002.bsky.social · 21/09/2026
The Billionaire-Free Packers Stay True to the Game www.nytimes.com/2026/09/20/o...
nytimes.com
Opinion | The Billionaire-Free Packers Stay True to the Game (Gift Article)
The community-owned Green Bay Packers are growing more globally popular in an N.F.L. dominated by billionaire owners.
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Paul Tuite @tuite002.bsky.social · 21/09/2026
An M.I.T. Report Warns A.I. Is Causing ‘Cognitive Surrender.’ Universities Are in a Bind. www.nytimes.com/2026/09/15/u...
nytimes.com
An M.I.T. Report Warns A.I. Is Causing ‘Cognitive Surrender.’ Universities Are in a Bind. (Gift Article)
As A.I. upends education, university leaders have been all over the map about how to respond. It can be very confusing for students.
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Reposted by Paul Tuite
Mark Histed @markhisted.org · 20/09/2026
Several reports this wknd of Trump and Vought trying to impose control over NIH grants—that is, politicizing US cancer and dementia cure research. Big picture: that is just the same unitary executive logic they tried to impose on NIH months ago via regulation. We need to strike back at the root…
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Kristian G. Andersen @kgandersen.bsky.social · 20/09/2026
"White House Moves to Take Control of N.I.H. Grants" [everybody up in arms, as they should be, but for those who have been paying close attention, this has pretty much already happened - the realization just hasn't sunk in yet] www.nytimes.com/2026/09/20/s...
nytimes.com
White House Moves to Take Control of N.I.H. Grants (Gift Article)
Federal officials are drafting an executive order that would place grants under review by an outside panel, the latest effort to redirect billions of dollars in research spending.
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Paul Tuite @tuite002.bsky.social · 20/09/2026
How DraftKings Uses A.I. to Target the Gamblers Likeliest to Lose www.nytimes.com/2026/09/19/b...
nytimes.com
At DraftKings, AI Targets the Gamblers Likeliest to Lose (Gift Article)
Data science helps determine who receives betting incentives, but the company has resisted using similar technology to protect gamblers at risk of addiction.
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Matthew Bunn @matthew-bunn.bsky.social · 19/09/2026
This is fantastic reporting. Study was about to provide data that could have contributed to understanding why Black Americans face twice the risk of Alzheimer’s dementia as white Americans. So, of course, the Trump team terminated it.
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Jenna Norton @jenna-m-norton.bsky.social · 19/09/2026
Russell Vought is an extreme ideologue trying to shape the NIH (& the entire govt) to align with his narrow views. He is an author of Project 2025, the deeply unpopular Heritage Foundation blueprint. He has repeatedly broken the law to achieve his goals. www.propublica.org/article/russ...
propublica.org
Russell Vought, Trump’s Shadow President
From the wholesale gutting of federal agencies to the ongoing government shutdown, Russell Vought has drawn the road map for Trump’s second term. Vought has consolidated power to an extent that inside...
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Shobita Parthasarathy @shobitap.org · 17/09/2026
In my new Expert Voices column @science.org, I argue that the Trump admin's science strategy (as written in Kratsios' Science: A Golden Age)--which gives more authority & funding to the private sector to direct the research enterprise--will harm science, and further erode its public accountability.
science.org
Escaping a downward spiral for science and public accountability
In late July, Michael Kratsios, director of the White House Office of Science and Technology Policy (OSTP), released Science—A Golden Age, setting forth a strategy to revitalize US research and innova...
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Paul Tuite @tuite002.bsky.social · 19/09/2026
Trump Administration Updates: Trump Bans CNN, MS NOW and Politico From the White House www.nytimes.com/live/2026/09...
nytimes.com
Trump Administration Updates: Trump Bans CNN, MS NOW and Politico From the White House
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Reposted by Paul Tuite
The New York Times @nytimes.com · 18/09/2026
The gene is found predominantly in Southern Appalachia and may be one of the most powerful cancer-risk mutations ever found.
nyti.ms
This Rare Gene Drastically Raises Lung Cancer Risk in People Who Never Smoked
The gene is found predominantly in Southern Appalachia and may be one of the most powerful cancer-risk mutations ever found.
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