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Reposted by @tronstadlab.bsky.social

Eric Topol @erictopol.bsky.social · 04/03/2026

The proteome (>7,000 circulating proteins) in people with ME/CFS exhibits immune system, vascular and metabolic dysregulation compared with controls (and likely homologous in #LongCovid) www.cell.com/cell-reports...

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tronstadlab.bsky.social @tronstadlab.bsky.social · 02/06/2025

5/5-The multiscale protein patterns map a pathophysiology composed of interrelated elements that are likely to play roles in ME/CFS.

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tronstadlab.bsky.social @tronstadlab.bsky.social · 02/06/2025

4/5-Focused studies of secreted proteins (the secretome) supported intensified regulatory interactions related to immune activity, inflammation, vasculature, and metabolism.

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tronstadlab.bsky.social @tronstadlab.bsky.social · 02/06/2025

3/5-The widespread decrease of intracellular proteins in the blood (especially from skeletal muscle) may have different explanations - muscle mass, cell/tissue turnover, tissue perfusion, and more.

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tronstadlab.bsky.social @tronstadlab.bsky.social · 02/06/2025

2/5-Distinct patterns of tissue- and process-specific changes were seen, including broad increase in secreted proteins, effects on metabolic regulators and changes in immune cell-specific signatures - with a specific reduction in neutrophil-associated proteins.

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tronstadlab.bsky.social @tronstadlab.bsky.social · 02/06/2025

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights www.medrxiv.org/content/10.1... 1/5-Our new preprint on the blood proteome of ME/CFS is a deep dive into the pathophysiology. ~7000 blood proteins were measured in 54 ME/CFS and 27 healthy.

medrxiv.org

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition often triggered by infections. The underlying mechanism remains poorly understood, and diagnostic markers and ef...

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