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Craig Kaplan

@triggerloop.bsky.social
4K followers 808 following 8.9K posts

Professor, Department of Biological Sciences, University of Pittsburgh. RNA polymerase II mechanism, classic films, #classiccountdown once in awhile

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Craig Kaplan @triggerloop.bsky.social · 11m
The hearing was a farce but Dems could have used their time to get a bunch more stuff on the record by giving him questions allowing him to reveal information
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Craig Kaplan @triggerloop.bsky.social · 37m
It’s unserious
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Craig Kaplan @triggerloop.bsky.social · 38m
Zilch
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Craig Kaplan @triggerloop.bsky.social · 41m
He has zero aura!!!
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Craig Kaplan @triggerloop.bsky.social · 56m
Haven’t seen it
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Craig Kaplan @triggerloop.bsky.social · 1h
The second paper is from Di Noia lab at ICRM in Montreal, also describing the role of SEC proteins and histone readers MLLT1 and 3 www.nature.com/articles/s41...
nature.com
Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity - Nature
By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.
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Craig Kaplan @triggerloop.bsky.social · 1h
Potentially through the poised conformation identified by @voslab.org 2/ www.sciencedirect.com/science/arti...
sciencedirect.com
Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing
Metazoan gene expression regulation involves pausing of RNA polymerase (Pol II) in the promoter-proximal region of genes and is stabilized by DSIF and…
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Craig Kaplan @triggerloop.bsky.social · 1h
Two extremely cool new papers on how AID gets targeted to appropriate genes for somatic hypermutation: paper 1 from Schatz lab at Yale shows that NELF and elongation components of the SEC are required- and suggests NELF can travel into genes /1 www.nature.com/articles/s41...
nature.com
Transcription pause and elongation regulators mediate somatic hypermutation - Nature
The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are i...
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Craig Kaplan @triggerloop.bsky.social · 3h
😡
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Craig Kaplan @triggerloop.bsky.social · 20h
HOW DARE
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Craig Kaplan @triggerloop.bsky.social · 22h
static.klipy.com
Deliciosas Enchiladas Mexicanas
Alt: Deliciosas Enchiladas Mexicanas
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
static.klipy.com
Dominique Wilkins' Iconic Windmill Dunk
Alt: Dominique Wilkins' Iconic Windmill Dunk
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
“As was the style at the time”
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
The Search is very special and he’s as hyper realistic as the actual rubble around him appears on celluloid
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Reposted by Craig Kaplan
Ben Winters @benwinters.bsky.social · 29/09/2026
that chatbot doing that unsafe/violative thing is not it 'going rogue' or an 'unfortunate incident of unintended consequences,' it’s the logical and devastating consequences of an unsafe product put out by irresponsible companies that have been conditioned to believe consequences dont exist for them
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Reposted by Craig Kaplan
Cees Dekker @ceesdekker.bsky.social · 29/09/2026
Here's our latest #CDlab paper in Nature Comm: a study of nucleocytoplasmic transport via nuclear pore complexes (NPCs), involving designer Nups, biomimetic NPCs, condensates, extensive MD simulations. Great collaboration with particularly the Onck lab. www.nature.com/articles/s41...
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
He's gonna do more turns than John Glenn!
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
😭
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
A great one! Liz Phair Supernova would also be great
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
Let’s see if they go crazy and throw on some Ministry from With Sympathy
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Reposted by Craig Kaplan
Souf Oaklin fo’ Life!!! @soufoaklin.bsky.social · 29/09/2026
The Cathedral is 100! And we’ve been covering her the whole time. Read the best stories from the past century.
soufoaklin.wordpress.com
Celebrating 100 years of the Cathedral of Learning
To mark 100 years of Oakland’s favorite stone monolith, we dove deep into the vault to bring you the real, unvarnished history of the Cathedral of Learning. From gothic angst and basement bangers t…
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
❤️❤️❤️❤️
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Reposted by Craig Kaplan
Dr. Peter Paul Rubens @peterpaulrubens.bsky.social · 29/09/2026
Roses, peonies, passion flower & more in a glass vase, plus ladybug crawling up table. And butterfly. All by Carstian Luyckx. It's been his day.
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Reposted by Craig Kaplan
Mark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026
For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu
Front page of the website
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Craig Kaplan @triggerloop.bsky.social · 29/09/2026
People were like he could get 100 catches this year and he’s barely gotten a target!
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
Amazing move to claim that conservatives have been let down by republicans - you have to get into the weeds on the Trinity to get out of that pretzel
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
“I’m sorry. It was wrong to poison the other team’s water. I shouldn’t have done that. I’ve updated my model to prevent that in the future”
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Reposted by Craig Kaplan
Carl Zimmer @carlzimmer.com · 28/09/2026
Bundibugyo outbreak tops 8,000 confirmed cases as disease remains out of control apnews.com/article/cong...
apnews.com
Congo's Ebola outbreak tops 8,000 confirmed cases as disease remains out of control
The number of confirmed Ebola cases in Congo has surged past 8,000 as the country struggles with a shortage of health workers. The new statistics were released Sunday.
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
A24 (2027 release)
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
Yes
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
Where the doors won’t open
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
But my note about the RT is the case. The RT itself would have been annotated before and this is even stated in the preprint
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
There are now claims that the RNA and repeat aspect were derived from user prompts or potentially patent filings as Claude users had made this discovery earlier but had not published.
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
😩yes
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Craig Kaplan @triggerloop.bsky.social · 28/09/2026
I would like for her an Conor F to put together a gigantic, impossible to assemble piece of IKEA furniture.
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
The RT was annotated in the sequence previously for sure, but what was discovered was the associated clustered repeats that are expressed and appear to associate with the RT, i.e a potential anti-viral system of unknown function but potentially programmable in some way
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Reposted by Craig Kaplan
c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...
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Reposted by Craig Kaplan
Matt Zoller Seitz @mattzollerseitz.bsky.social · 27/09/2026
Chicago: don't miss this one One of the best horror films of the 60s Also chef's kiss B&W CinemaScope, absolutely gorgeous
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
It looks so amazingly good- what a gift to see on the big screen
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
the fish are rising and there a hatches I need to be there for
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
Fantastic. Love it
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
WOW!!
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
Who is winning or who won
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
There is a little punch card like at the local sub shop. One free pee with 5 sacks and they have eggplant emoji shaped hole puncher
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
One method I like that few places use is à la carte pricing
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
This is a fascinating story but the top throughline should be current administration destruction of science
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
Same as interceptions that bounce out of the breadbasket
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
Nothing matters - that was my morning vibe - one million ways it could have been different- I’m not doing math
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
Chewing Gum came on other day and it goes so hard
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Craig Kaplan @triggerloop.bsky.social · 27/09/2026
I woke up this morning and was like game goes to OT if M had kicked PAT(no reason to, just that dumb of a game)
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