Craig Kaplan @triggerloop.bsky.social · 11mThe hearing was a farce but Dems could have used their time to get a bunch more stuff on the record by giving him questions allowing him to reveal information 000
Craig Kaplan @triggerloop.bsky.social · 1hThe second paper is from Di Noia lab at ICRM in Montreal, also describing the role of SEC proteins and histone readers MLLT1 and 3 www.nature.com/articles/s41...nature.comHistone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity - NatureBy being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation. 040
Craig Kaplan @triggerloop.bsky.social · 1hPotentially through the poised conformation identified by @voslab.org 2/ www.sciencedirect.com/science/arti...sciencedirect.comDistinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausingMetazoan gene expression regulation involves pausing of RNA polymerase (Pol II) in the promoter-proximal region of genes and is stabilized by DSIF and… 130
Craig Kaplan @triggerloop.bsky.social · 1hTwo extremely cool new papers on how AID gets targeted to appropriate genes for somatic hypermutation: paper 1 from Schatz lab at Yale shows that NELF and elongation components of the SEC are required- and suggests NELF can travel into genes /1 www.nature.com/articles/s41...nature.comTranscription pause and elongation regulators mediate somatic hypermutation - NatureThe molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are i... 181
Craig Kaplan @triggerloop.bsky.social · 22hstatic.klipy.comDeliciosas Enchiladas MexicanasAlt: Deliciosas Enchiladas Mexicanas 010
Craig Kaplan @triggerloop.bsky.social · 29/09/2026static.klipy.comDominique Wilkins' Iconic Windmill DunkAlt: Dominique Wilkins' Iconic Windmill Dunk 000
Craig Kaplan @triggerloop.bsky.social · 29/09/2026The Search is very special and he’s as hyper realistic as the actual rubble around him appears on celluloid 010
Reposted by Craig KaplanBen Winters @benwinters.bsky.social · 29/09/2026that chatbot doing that unsafe/violative thing is not it 'going rogue' or an 'unfortunate incident of unintended consequences,' it’s the logical and devastating consequences of an unsafe product put out by irresponsible companies that have been conditioned to believe consequences dont exist for them 7772249
Reposted by Craig KaplanCees Dekker @ceesdekker.bsky.social · 29/09/2026Here's our latest #CDlab paper in Nature Comm: a study of nucleocytoplasmic transport via nuclear pore complexes (NPCs), involving designer Nups, biomimetic NPCs, condensates, extensive MD simulations. Great collaboration with particularly the Onck lab. www.nature.com/articles/s41... 081
Craig Kaplan @triggerloop.bsky.social · 29/09/2026A great one! Liz Phair Supernova would also be great 110
Craig Kaplan @triggerloop.bsky.social · 29/09/2026Let’s see if they go crazy and throw on some Ministry from With Sympathy 100
Reposted by Craig KaplanSouf Oaklin fo’ Life!!! @soufoaklin.bsky.social · 29/09/2026The Cathedral is 100! And we’ve been covering her the whole time. Read the best stories from the past century.soufoaklin.wordpress.comCelebrating 100 years of the Cathedral of LearningTo mark 100 years of Oakland’s favorite stone monolith, we dove deep into the vault to bring you the real, unvarnished history of the Cathedral of Learning. From gothic angst and basement bangers t… 131
Reposted by Craig KaplanDr. Peter Paul Rubens @peterpaulrubens.bsky.social · 29/09/2026Roses, peonies, passion flower & more in a glass vase, plus ladybug crawling up table. And butterfly. All by Carstian Luyckx. It's been his day. 310320
Reposted by Craig KaplanMark Peifer (He, him) @peiferlabunc.bsky.social · 29/09/2026For the last 34 years I have been on the faculty of the UNC-Chapel Hill Department of Biology and have never regretted that decision. This year we are hiring TWO new Assistant Professors in the broad area of Molecular, Cell, Developmental Biology 1/n bio.unc.edu 3147135
Craig Kaplan @triggerloop.bsky.social · 29/09/2026People were like he could get 100 catches this year and he’s barely gotten a target! 010
Craig Kaplan @triggerloop.bsky.social · 28/09/2026Amazing move to claim that conservatives have been let down by republicans - you have to get into the weeds on the Trinity to get out of that pretzel 000
Craig Kaplan @triggerloop.bsky.social · 28/09/2026“I’m sorry. It was wrong to poison the other team’s water. I shouldn’t have done that. I’ve updated my model to prevent that in the future” 050
Reposted by Craig KaplanCarl Zimmer @carlzimmer.com · 28/09/2026Bundibugyo outbreak tops 8,000 confirmed cases as disease remains out of control apnews.com/article/cong...apnews.comCongo's Ebola outbreak tops 8,000 confirmed cases as disease remains out of controlThe number of confirmed Ebola cases in Congo has surged past 8,000 as the country struggles with a shortage of health workers. The new statistics were released Sunday. 24125
Craig Kaplan @triggerloop.bsky.social · 28/09/2026But my note about the RT is the case. The RT itself would have been annotated before and this is even stated in the preprint 060
Craig Kaplan @triggerloop.bsky.social · 28/09/2026There are now claims that the RNA and repeat aspect were derived from user prompts or potentially patent filings as Claude users had made this discovery earlier but had not published. 2110
Craig Kaplan @triggerloop.bsky.social · 28/09/2026I would like for her an Conor F to put together a gigantic, impossible to assemble piece of IKEA furniture. 000
Craig Kaplan @triggerloop.bsky.social · 27/09/2026The RT was annotated in the sequence previously for sure, but what was discovered was the associated clustered repeats that are expressed and appear to associate with the RT, i.e a potential anti-viral system of unknown function but potentially programmable in some way 3494
Reposted by Craig Kaplanc0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently... 7253110
Reposted by Craig KaplanMatt Zoller Seitz @mattzollerseitz.bsky.social · 27/09/2026Chicago: don't miss this one One of the best horror films of the 60s Also chef's kiss B&W CinemaScope, absolutely gorgeous 3335
Craig Kaplan @triggerloop.bsky.social · 27/09/2026It looks so amazingly good- what a gift to see on the big screen 021
Craig Kaplan @triggerloop.bsky.social · 27/09/2026the fish are rising and there a hatches I need to be there for 000
Craig Kaplan @triggerloop.bsky.social · 27/09/2026There is a little punch card like at the local sub shop. One free pee with 5 sacks and they have eggplant emoji shaped hole puncher 000
Craig Kaplan @triggerloop.bsky.social · 27/09/2026One method I like that few places use is à la carte pricing 010
Craig Kaplan @triggerloop.bsky.social · 27/09/2026This is a fascinating story but the top throughline should be current administration destruction of science 051
Craig Kaplan @triggerloop.bsky.social · 27/09/2026Same as interceptions that bounce out of the breadbasket 010
Craig Kaplan @triggerloop.bsky.social · 27/09/2026Nothing matters - that was my morning vibe - one million ways it could have been different- I’m not doing math 000
Craig Kaplan @triggerloop.bsky.social · 27/09/2026Chewing Gum came on other day and it goes so hard 010
Craig Kaplan @triggerloop.bsky.social · 27/09/2026I woke up this morning and was like game goes to OT if M had kicked PAT(no reason to, just that dumb of a game) 100