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Translucence Biosystems

@translucencebio.bsky.social
35 followers 19 following 344 posts

Leaders in next-generation 3D histology and AI-powered quantification for intact biological samples

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Translucence Biosystems @translucencebio.bsky.social · 09/10/2026
We had a fun week in the lab getting hands-on time with our new light sheet microscope from Bruker luxendo! Thank you to Jan Frankowski and the rest of the Bruker team for their time, expertise, and support. We’re excited about this partnership and looking forward to what’s next! #tissueclearing
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Translucence Biosystems @translucencebio.bsky.social · 07/10/2026
TO-PRO can also be combined with any validated antibodies, adding nuclear context to your markers of interest. Learn more about our science: translucencebio.com/our-science (4/🧵)
translucencebio.com
Our Science | Translucence Biosystems
At Translucence Biosystems, we are pioneering a dimensional shift from 2D to 3D histology by developing tissue clearing, light sheet fluorescence microscopy (LSFM), and 3D AI-powered quantification…
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Translucence Biosystems @translucencebio.bsky.social · 07/10/2026
Here, TO-PRO reveals cellular organization across a cleared mouse brain, from the whole-brain view to the detailed architecture of the olfactory bulb, cortex, and cerebellum. (3/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 07/10/2026
That versatility extends to challenging stains like TO-PRO. Nuclear labeling in intact tissue can be difficult, but it’s achievable with our kits. (2/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 07/10/2026
The Translucence Universal Tissue Clearing Kit supports a wide range of tissues and your choice of validated antibodies, giving you the flexibility to explore biology in 3D. (1/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 10/09/2026
To learn more about how we are combining these technologies, read the collaboration announcement here: www.bruker.com/de/news-and-... #Bruker #Partnership #TissueClearing #LightSheetMicroscopy #3DImaging (5/🧵)
bruker.com
Bruker Advances Whole-Organism 3D Imaging with Enhanced Tissue-Clearing Workflows
MADISON, Wisconsin, September 8, 2026 – Bruker Corporation today announced a strategic collaboration with Translucence Biosystems, Inc., a leading provider of tissue-clearing solutions, to expand its ...
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Translucence Biosystems @translucencebio.bsky.social · 10/09/2026
Together, these technologies are intended to simplify the path from sample preparation to high-resolution analysis-ready 3D datasets, helping researchers study intact biological tissues with greater reproducibility and reduced technical complexity. (4/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 10/09/2026
The collaboration brings together our Universal Tissue Clearing Kit with Bruker’s MuVi SPIM and LCS SPIM light sheet microscopes, LuxBundle Software, Acquifer HIVE data infrastructure, and Translucence Quantification Services. (3/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 10/09/2026
This partnership will help create an integrated workflow for tissue clearing, light sheet microscopy, and data processing. (2/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 10/09/2026
We are excited to announce that we are entering a strategic partnership with Bruker Fluorescence Microscopy to make whole-organ 3D imaging more accessible to the greater scientific community. (1/🧵)
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Translucence Biosystems @translucencebio.bsky.social · 09/09/2026
Interested in bringing this type of work to your own lab? Check out our Kit page: www.translucencebio.com/universal-ti...
translucencebio.com
Universal Tissue Clearing Kit | Straightforward iDISCO-Based Clearing
No tissue clearing experience? No problem. A robust solution for all your tissue clearing needs. Clear and stain an extensive range of tissues, including mouse brain, lung, liver, spinal cord, and…
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Translucence Biosystems @translucencebio.bsky.social · 09/09/2026
Jenna’s work with Dr. Cole Vonder Haar focused on using ΔFosB to better understand sustained neuronal activation and adaptation following traumatic brain injury, with a particular interest in how post-injury circuit remodeling contributes to persistent behavioral impairments.
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Translucence Biosystems @translucencebio.bsky.social · 09/09/2026
Kit user highlight! The sample shown in the attached video was generated by Jenna McCloskey at The Ohio State University using a Translucence Biosystems Universal Tissue Clearing Kit. This video shows ΔFosB-positive cells across an intact rat brain hemisphere.
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Translucence Biosystems @translucencebio.bsky.social · 20/08/2026
RSVP for the event and share it with a colleague: tinyurl.com/tbs-open-mic
tinyurl.com
Tissue Clearing Lunch n' Learn with Translucence Biosystems @ UC Berkeley
Description: At this event we will provide a comprehensive overview of tissue clearing, walk you through the basic steps, best practices, and how tissue clearing can be applied to your biological…
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Translucence Biosystems @translucencebio.bsky.social · 20/08/2026
UC Berkeley researchers, students, and anyone interested in tissue clearing, light sheet imaging, or 3D histology are encouraged to attend. Learn how 3D histology can help visualize intact biological systems and enable richer spatial analysis.
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Translucence Biosystems @translucencebio.bsky.social · 20/08/2026
Event details: When: Tuesday, September 1, 2026 | 12:00–1:00 p.m. Where: Weill Hall, Floor 1, Room 177 Catering: Zachary’s Pizza   The presentation will be followed by a Q&A session.
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Translucence Biosystems @translucencebio.bsky.social · 20/08/2026
Attendees will receive a comprehensive overview of tissue clearing, including the basic workflow, best practices, and how these methods can support 3D imaging and quantitative biological research.
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Translucence Biosystems @translucencebio.bsky.social · 20/08/2026
Coming up in less than two weeks: Join us at @ucberkeleyofficial.bsky.social for a Tissue Clearing Lunch ‘n’ Learn, presented in collaboration with the Cancer Research Laboratory’s Molecular Imaging Center.
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Translucence Biosystems @translucencebio.bsky.social · 19/08/2026
Interested in bringing this work to your lab? Check out our Universal Tissue Clearing Kit product page: www.translucencebio.com/universal-ti...
translucencebio.com
Universal Tissue Clearing Kit | Straightforward iDISCO-Based Clearing
No tissue clearing experience? No problem. A robust solution for all your tissue clearing needs. Clear and stain an extensive range of tissues, including mouse brain, lung, liver, spinal cord, and mor...
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Translucence Biosystems @translucencebio.bsky.social · 19/08/2026
Whole-organ imaging preserves the spatial relationship between these structures across the kidney, providing robust anatomical context that is difficult to capture from isolated sections alone. #tissueclearing #zeiss #lightsheet #3d
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Translucence Biosystems @translucencebio.bsky.social · 19/08/2026
AQP2, shown in green, labels collecting duct structures throughout the tissue. SMA, shown in cyan, provides complementary structural context by labeling smooth muscle associated with the renal vasculature.
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Translucence Biosystems @translucencebio.bsky.social · 19/08/2026
This 3D visualization, captured on a #Zeiss lightsheet, shows Aquaporin-2 (AQP2) and smooth muscle actin (SMA) staining across an intact mouse kidney cleared with our Universal Tissue Clearing Kit!
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Translucence Biosystems @translucencebio.bsky.social · 07/08/2026
Interested in generating datasets like this? Check out our NIH-funded tissue clearing kits to bring this work to your own lab: www.translucencebio.com/universal-ti...
translucencebio.com
Universal Tissue Clearing Kit | Straightforward iDISCO-Based Clearing
No tissue clearing experience? No problem. A robust solution for all your tissue clearing needs. Clear and stain an extensive range of tissues, including mouse brain, lung, liver, spinal cord, and…
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Translucence Biosystems @translucencebio.bsky.social · 07/08/2026
Here, tissue clearing and light-sheet imaging allow for the generation of 3D kidney volumes which elucidate the spatial organization of AQP2-positive collecting duct structures in a way that is difficult to capture from 2D sections alone. #fluorescencefriday #tissueclearing #thepowerof3D
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Translucence Biosystems @translucencebio.bsky.social · 07/08/2026
In this video of an adult mouse kidney, one can see Aquaporin-2 (AQP2), in green, and a morphological marker in red. AQP2 labels collecting ducts throughout the kidney while the morphological marker provides additional structural context across the tissue.
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Translucence Biosystems @translucencebio.bsky.social · 07/08/2026
This video highlights the power of tissue clearing and lightsheet imaging for providing deeper, spatially resolved insights in biological research.
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Translucence Biosystems @translucencebio.bsky.social · 05/08/2026
RSVP for the event and share it with a colleague: tinyurl.com/tbs-open-mic
tinyurl.com
Tissue Clearing Lunch n' Learn with Translucence Biosystems @ UC Berkeley
Description: At this event we will provide a comprehensive overview of tissue clearing, walk you through the basic steps, best practices, and how tissue clearing can be applied to your biological rese...
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Translucence Biosystems @translucencebio.bsky.social · 05/08/2026
UC Berkeley researchers, students, and anyone interested in tissue clearing, light sheet imaging, or 3D histology are encouraged to attend. This is an opportunity to learn how 3D histology can help visualize intact biological systems and enable richer spatial analysis.
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Translucence Biosystems @translucencebio.bsky.social · 05/08/2026
Event details: 🗓️ When: Tuesday, September 1, 2026 | 12:00–1:00 p.m. 📍 Where: Weill Hall, Floor 1, Room 177 🍕 Catering: Zachary’s Pizza The presentation will be followed by a Q&A session.
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Translucence Biosystems @translucencebio.bsky.social · 05/08/2026
Attendees will receive a comprehensive overview of tissue clearing, including the basic workflow, best practices, and how these methods can be applied to support 3D imaging and quantitative biological research.
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Translucence Biosystems @translucencebio.bsky.social · 05/08/2026
Coming up next month: Join us at @ucberkeleyofficial.bsky.social for a Tissue Clearing Lunch ’n’ Learn, presented in collaboration with the Cancer Research Laboratory’s Molecular Imaging Center.
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Translucence Biosystems @translucencebio.bsky.social · 31/07/2026
Here, tissue clearing and light-sheet imaging allow for the generation of 3D kidney volumes which elucidate the spatial organization of AQP2-positive collecting duct structures in a way that is difficult to capture from 2D sections alone.
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Translucence Biosystems @translucencebio.bsky.social · 31/07/2026
In this video of an adult mouse kidney, one can see Aquaporin-2 (AQP2), in green, and a morphological marker in red. AQP2 labels collecting ducts throughout the kidney while the morphological marker provides additional structural context across the tissue.
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Translucence Biosystems @translucencebio.bsky.social · 01/07/2026
We're proud to support opportunities that inspire future innovators and help students explore what's possible in the life sciences. To learn more about the courses and training programs University Lab Partners offers, visit the link below: www.universitylabpartners.org/education
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Translucence Biosystems @translucencebio.bsky.social · 01/07/2026
Through these programs, students gain valuable insight into STEM careers by learning practical skills and connecting directly with scientists and industry professionals.
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Translucence Biosystems @translucencebio.bsky.social · 01/07/2026
University Lab Partners provides hands-on education and laboratory training that provides high school and college students with real-world experience in biotechnology, molecular biology, cancer research, and other life science disciplines.
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Translucence Biosystems @translucencebio.bsky.social · 01/07/2026
Nathaniel will share his journey into science, his current role at Translucence Biosystems, and the experiences that shaped his career.
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Translucence Biosystems @translucencebio.bsky.social · 01/07/2026
We love supporting and engaging with the next generation of scientists! Today at 1 PM, Director of Products and Business Development, Nathaniel Guansona, is speaking at University Lab Partners' Meet the Scientist series.
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Translucence Biosystems @translucencebio.bsky.social · 17/06/2026
Register here: events.bizzabo.com/885003 Read the full paper here: www.nature.com/articles/s41...
events.bizzabo.com
Brainsight Breakthroughs: Astrocytes connect specific brain regions through plastic networks
Neuronal axons have traditionally been considered to be the primary mediators of functional connectivity among brain regions. Astrocytes communicate with one another through gap junctions, but the ext...
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Translucence Biosystems @translucencebio.bsky.social · 17/06/2026
Join the webinar on Wednesday, June 17th at 11:00 AM EST / 08:00 AM PST. The Translucence Biosystems team will be there to answer questions about the 3D whole-brain quantification that went into this study. We look forward to seeing you there!
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Translucence Biosystems @translucencebio.bsky.social · 17/06/2026
Below, Melissa describes the analysis challenges that come with quantifying terabyte-scale light sheet datasets, including stitching, registration, and generating actionable insights. Here she also highlights Translucence Biosystems’ role in helping make this work possible.
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Translucence Biosystems @translucencebio.bsky.social · 17/06/2026
We are grateful to have collaborated with Melissa Cooper, PhD, Shane Liddelow, Moses Chao, and the team at NYU Grossman School of Medicine, and to contribute to the whole-brain quantification behind this work.
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Translucence Biosystems @translucencebio.bsky.social · 17/06/2026
Tune in tomorrow for the Brainsight Breakthroughs webinar from ZEISS Microscopy featuring Melissa Cooper, PhD, and her recent work on astrocyte networks across the intact brain.
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Translucence Biosystems @translucencebio.bsky.social · 05/06/2026
At Translucence, we are proud to support researchers by developing tissue clearing, light sheet imaging, and AI-powered 3D quantification workflows for Alzheimer's Disease research. #alzheimersdisease #ADresearch #ENDALZ #AAIC
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Translucence Biosystems @translucencebio.bsky.social · 05/06/2026
As researchers work to better characterize pathology, neuroinflammation, and therapeutic response, whole-brain approaches can provide a more comprehensive view of these processes across the intact brain.
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Translucence Biosystems @translucencebio.bsky.social · 05/06/2026
Alzheimer’s disease is characterized by complex pathology, making spatial context critical for understanding disease biology.
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Translucence Biosystems @translucencebio.bsky.social · 05/06/2026
This month, we recognize the scientists, clinicians, patients, families, and advocates working to advance Alzheimer’s research and deepen our understanding of the brain.
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Translucence Biosystems @translucencebio.bsky.social · 05/06/2026
June is Alzheimer’s and Brain Awareness Month, a time to recognize the impact of Alzheimer’s disease and the importance of continued progress in brain research.
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Translucence Biosystems @translucencebio.bsky.social · 27/05/2026
In developmental specimens like this, these workflows provide a more comprehensive view of how tissue organization and neural architecture emerge across the embryo.
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Translucence Biosystems @translucencebio.bsky.social · 27/05/2026
Whole-sample tissue clearing combined with 3D light-sheet imaging makes it possible to examine these structures within their native spatial context rather than through isolated tissue sections.
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